New York Giants vs Los Angeles Rams Prediction 9/21/2026 Today’s NFL Picks
Chris Ruffolo
Sep 13, 2026; East Rutherford, New Jersey, USA; New York Giants quarterback Jaxson Dart (6) scrambles with the ball against the Dallas Cowboys during the second quarter at MetLife Stadium. Mandatory Credit: Brad Penner-Imagn Images
MATCHUP
New York Giants
Los Angeles Rams
Team Records
1-0
0-1
Spread
+7 -120
-7 100
Moneyline
+245
-305
Total
Over 47.5 (-110)
Under 47.5 (-110)
Where
SoFi Stadium, Inglewood, CA
When
Monday, September 21, 2026
Time
08:15 PM EDT
TV
ESPN
The New York Giants and the Los Angeles Rams meet in week 2 NFL action from SoFi Stadium on Monday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Giants vs. Los Angeles Rams prediction.
New York Giants Recap
The New York Giants come into this game looking to add on to their 28-20 win over the Dallas Cowboys last time out to start the year at 1-0. After this game, the Giants will head home for a game against the Tennessee Titans.
Giants Looking To Remain Unbeaten After Division Win
Jaxson Dart has thrown for 230 yards, 3 touchdowns and 0 interceptions on 79.3% passing while Cam Skattebo leads the Giants in rushing with 81 rushing yards and 1 touchdown so far this season. Dart sits behind Skattebo on the ground with 54 yards and 0 TDs. Isaiah Likely leads New York in receiving with 78 yards and 8 catches along with 2 touchdowns, while Malik Nabers trails closely with 69 yards on 6 catches. Devin Singletary pulled in the team’s other receiving touchdown. On defense, Tremaine Edmunds has a team-high 8 total tackles while Jevon Holland recorded the team’s lone interception. New York’s defense as a whole has combined for 0 sacks and 1 interception so far this season.
Los Angeles Rams Recap
The Los Angeles Rams come into this game looking to bounce back from a 27-7 loss at the hands of the San Francisco 49ers to start the year at 0-1. After this game, the Rams will head on the road for a game against the Denver Broncos.
Rams Looking To Bounce Back On Home Soil
Matthew Stafford has thrown for 155 yards, 0 touchdowns and 1 interception on 60.0% passing while Blake Corum leads the Rams in rushing with 54 rushing yards and 0 touchdowns so far this season. Kyren Williams sits right behind Corum on the ground with 41 yards and pulled in the team’s lone rushing touchdown. Puka Nacua leads Los Angeles in receiving with 74 yards on 5 catches, while Davante Adams trails with 26 yards on 3 catches. On defense, Quentin Lake has a team-high 10 total tackles and recorded the team’s lone interception. Los Angeles’s defense as a whole has combined for 0 sacks and 1 interception so far this season.
New York Giants @ Los Angeles Rams Betting Trends: Week 2
Why the Los Angeles Rams will win
The Giants have lost each of their last nine games against NFC opponents on a losing streak.
The Rams have won each of their last five Monday games against teams that held a winning record.
The Rams have covered the spread in each of their last five Monday games against teams that held a winning record.
The Giants have failed to cover the spread in each of their last four September games against NFC West opponents.
The Giants have lost the first half in 16 of their last 17 games against NFC West opponents.
The Giants have lost the first quarter in each of their last eight Monday games.
The Rams have scored the first touchdown in each of their last five games against the Giants.
Why the New York Giants will win
The Giants have won each of their last five games as underdogs without Jason Pinnock.
The Rams have lost each of their last five games against NFC East opponents on a winning streak.
The Giants have covered the spread in each of their last six Monday games against teams that held a losing record.
The Rams have failed to cover the spread in each of their last four games.
The Rams have lost the first half in three of their last four games as moderate favorites (-3.5 to -7.0 points).
The underdogs have won the first quarter in each of the Giants’ last five Week 2 games.
Total Points Facts
Each of the Rams’ last six Week 2 games have gone OVER the total points line.
Each of the Giants’ last four Monday games have gone OVER the total points line.
Los Angeles Rams Player Prop Facts
Kyren Williams has recorded 72+ rushing yards in each of the Rams’ last five games against NFC East opponents.
Kyren Williams has recorded 15+ receiving yards in each of the Rams’ last seven games.
Matthew Stafford has recorded 251+ passing yards in each of his last eight appearances with his team as a favorite against NFC East opponents.
Matthew Stafford has recorded 22+ completions in each of his last six Monday regular season appearances with his team as a favorite.
Kyren Williams has scored at least one touchdown in each of the Rams’ last eight September games against NFC opponents.
Kyren Williams has recorded 76+ rushing and receiving yards in each of his last six appearances following a home loss.
Kyren Williams has scored the first touchdown in three of the Rams’ last four regular season games against NFC East opponents.
Heading into Week 2, Kyren Williams ranks T1st amongst qualified players for catch rate (100.0%) this season.
New York Giants Player Prop Facts
Cameron Skattebo has scored at least one touchdown in each of his last four appearances.
Jaxson Dart has recorded 230+ passing yards in four of his last five appearances against NFC opponents.
Odell Beckham Jr. has recorded 23+ receiving yards in each of his 23 previous appearances with the Giants as road underdogs.
Jaxson Dart has recorded 20+ completions in four of the Giants’ last five games.
Tyrone Tracy has recorded 23+ rushing yards in 12 of his last 13 appearances with the Giants as road underdogs.
Tyrone Tracy has recorded 33+ rushing and receiving yards in each of his last 13 appearances with the Giants as road underdogs.
Heading into Week 2, Isaiah Likely ranks T1st in the NFL in receiving touchdowns (2) this season.
Matchup/League Facts
Heading into Week 2, the Rams rank 32nd in the NFL in points per game (7.0) this season.
Heading into Week 2, the Rams rank T1st in the NFL in 4th down attempts (3) this season.
Heading into Week 2, the Giants rank 1st in the NFL in 3rd down percentage (81.8%) this season.
Heading into Week 2, the Giants rank T1st in the NFL in 1st downs (29) this season.
New York Giants vs. Los Angeles Rams Prediction
I’m on the Rams in this one. I get the case to be made for the Giants in this one as they looked good in the opener, but my problem with the Giants in this game is that you’re getting a ticked off Rams team that looked unprepared and just downright sloppy in their opener and now they inally get back home with time to prepare properly and I think this will be a bit of a step up that the Giants may not be prepared for. I think the Rams bounce back here and get it done so give me Los Angeles.
