New Orleans Saints vs Seattle Seahawks Prediction 9/21/2025 Today’s NFL Picks

In this article, we will formulate a Saints vs Seahawks Prediction for this NFL Week 3 game on Sunday, September 21st at the Lumen Field. Let’s take a look at the prediction for this NFL matchup.

Seattle Seahawks Preview

Seattle has a 1-1 record this season and are coming off a 31-17 road victory in Pittsburgh. Offensively, the Seahawks average 22.0 points per game, which ranks 16th in the league. Defensively, they allow 17.0 points per game, which ranks 7th. Seattle averages 312.5 total yards per game, with 100.5 rushing yards and 212.0 passing yards per game. They allow 325.5 total yards per game, 95.5 of them rushing and 230.0 passing yards per game.

Sam Darnold leads the Seahawks with 38/56 completed passes and 445 total passing yards. He also adds 14 rushing yards. Kenneth Walker III leads the team in rushing yards, with 125 and 1 touchdown, while Zach Charbonnet adds 57 rushing yards and 1 touchdown. Jaxon Smith-Njigba has a team-high 17 caught passes for a team-high 227 receiving yards. Cooper Kupp has caught 9 passes for 105 yards.

Defensively, Ernest Jones has a team-high 18 total tackles, 11 of them solo. Byron Murphy leads the Seahawks in sacks, with 1.5, while Coby Bryant has 1 interception, Ernest Jones has 1 interception, Josh Jobe has 1 interception, and Derion Kendrick has 1 interception.

New Orleans Saints Preview

New Orleans has a 0-2 record this season and are coming off a 21-26 home defeat by San Francisco. Offensively, the Saints average 17.0 points per game, which ranks 26th in the league. Defensively, they allow 23.0 points per game, which ranks 17th. New Orleans averages 311.0 total yards per game, with 114.0 rushing yards and 197.0 passing yards per game. They allow 310.0 total yards per game, 111.5 of them rushing and 198.5 passing yards per game.

Spencer Rattler leads the Saints with 52/80 completed passes and 421 total passing yards. He also adds 43 rushing yards. Alvin Kamara leads the team in rushing yards, with 144 and 1 touchdown, while Spencer Rattler adds 43 rushing yards. Juwan Johnson has a team-high 13 caught passes for a team-high 125 receiving yards, and has 1 touchdown. Chris Olave has caught 13 passes for 108 yards.

Defensively, Demario Davis has a team-high 20 total tackles, 11 of them solo. Pete Werner adds 14 total tackles, 12 of them solo. Carl Granderson leads the Saints in sacks, with 3.5, while the Saints had no interception in the game.

New Orleans Saints @ Seattle Seahawks Betting Trends: Week 3

Why the Seattle Seahawks will win

• The Saints have lost each of their last six games.
• The favorites have won each of the Saints’ last eight games.
• The Saints have failed to cover the spread in each of their last six games as underdogs against NFC West opponents.
• The favorites have covered the spread in six of the Seahawks’ last seven games at Lumen Field.
• The Seahawks have scored the first touchdown in each of their last five games played as favorites on the West Coast.
• The Saints have lost the first half in seven of their last eight games against NFC West opponents.
• The Saints have lost the first quarter in five of their last six games.

Why the New Orleans Saints will win

• The underdogs have won each of the Saints’ last nine Week 3 games.
• The Seahawks have lost seven of their last eight home games.
• The underdogs have covered the spread in each of the Saints’ last 10 Week 3 games.
• The Seahawks have failed to cover the spread in each of their last six home games before a Division game.
• The Saints have scored the first touchdown in nine of their last 11 Week 3 games.
• The Saints have won the first half in seven of their last eight Week 3 games.
• The road team has won the first quarter in each of the Seahawks’ last seven games.

Total Points Facts

• Ten of the Seahawks’ last 11 home games against NFC South opponents have gone OVER the total points line.
• Each of the Saints’ last four Week 3 games have gone UNDER the total points line.
• Five of the last six Sunday games at Lumen Field have gone UNDER the total points line.

Seattle Seahawks Player Prop Facts

• Cooper Kupp has scored at least one touchdown in each of his last five Week 3 appearances.
• Cooper Kupp has recorded 40+ receiving yards in each of his last 13 September appearances with his team as a favorite.
• Kenneth Walker III has scored two or more touchdowns in three of the Seahawks’ last four September games against NFC opponents.
• Sam Darnold has recorded 231+ passing yards in each of his last 12 appearances with his team as a favorite.
• Kenneth Walker III has recorded 51+ rushing yards in each of his eight previous appearances with the Seahawks as favorites following a win.
• Cooper Kupp has recorded 40+ rushing and receiving yards in each of his last 13 September appearances with his team as a favorite.
• Sam Darnold has recorded 20+ completions in each of his last 10 appearances with his team as a favorite.
• Heading into Week 3, Boye Mafe ranks 1st in the NFL in quarterback hurries (4) this season.

New Orleans Saints Player Prop Facts

• Alvin Kamara has scored at least one touchdown in each of the Saints’ last four September games as road underdogs.
• Brandin Cooks has recorded 16+ receiving yards in each of his last 28 September appearances.
• Spencer Rattler has recorded 207+ passing yards in each of the Saints’ last four games.
• Alvin Kamara has recorded 58+ rushing yards in each of his last six Week 3 appearances.
• Brandin Cooks has recorded 19+ rushing and receiving yards in each of his 21 previous appearances with the Saints as underdogs.
• Spencer Rattler has recorded 25+ completions in each of the Saints’ last three games.
• Heading into Week 3, Carl Granderson ranks T1st in the NFL in sacks (3.5) this season.

Matchup/League Facts

• Seahawks – one different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Seahawks – one different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Saints – one different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Saints – one different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.

Saints vs Seahawks Prediction

In their most recent meeting back in 2022, New Orleans won 39-32 at home, covering the spread. The Saints have their last four meetings against the Seahawks, but both teams are tied 3-3 wins in their last 6 meetings in Seattle. Under is 4-2 in their last 6 meetings.  

In this Saints vs Seahawks Prediction, the Seahawks are coming as -7.5-point home favorites, with the total set at 41.5 points. The Saints are looking terrible so far, having lost and failed to cover both of their games, losing by an average of 6 points per game. On the flip side, Seattle bounced back after a defeat in their season opener, and are looking for their first home win this season. They have the 7th-best defense in the league, and I don’t think they will have a problem against a struggling Saints squad. Take the Seattle Seahawks and lay the -7.5 points at home.