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Minnesota Vikings vs Los Angeles Chargers Prediction 10/23/2025 Today’s NFL Picks

Sep 21, 2025; Minneapolis, Minnesota, USA; Minnesota Vikings running back Jordan Mason (27) carries the ball against the Cincinnati Bengals during the second half at U.S. Bank Stadium. Mandatory Credit: Brad Rempel-Imagn Images

Sep 21, 2025; Minneapolis, Minnesota, USA; Minnesota Vikings running back Jordan Mason (27) carries the ball against the Cincinnati Bengals during the second half at U.S. Bank Stadium. Mandatory Credit: Brad Rempel-Imagn Images

Minnesota (3-3) vs Los Angeles (4-3)

October 23, 2025 at 08:15 PM EDT

The Line: Betting Odds: Los Angeles -3 — Over/Under: +44.5

(Get latest betting odds)

The Minnesota Vikings and the Los Angeles Chargers meet in week 8 NFL action from SoFi Stadium on Thursday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Vikings vs. Los Angeles Chargers prediction.

Minnesota Vikings Recap

The Minnesota Vikings come into this game looking to bounce back from a 28-22 loss at the hands of Philadelphia last time out to sit at 3-3 this season. After this game, Minnesota will head on the road for a game against the Detroit Lions.

Vikings Alternate Wins & Losses In Each Of First 6 Games

Carson Wentz has thrown for 1,072 yards, 5 touchdowns and 4 interceptions on 66.9% passing while J.J. McCarthy’s thrown for 301 yards, 2 touchdowns and 3 picks so far this year. Jordan Mason leads Minnesota with 380 rushing yards and 4 touchdowns while Justin Jefferson has a team-high 34 catches for 528 yards and a touchdown to lead Minnesota’s receiving group. Jordan Addison has 283 receiving yards while T.J. Hockenson and Jalen Nailor each have 150+ receiving yards as well this season. On defense, Eric Wilson has a team-high 41 total tackles while Jalen Redmond has a team-high 3 sacks. As a unit, Minnesota’s defense has combined for 16 sacks and 2 interceptions so far this season. 

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to bounce back from their 38-24 loss at the hands of the Indianapolis Colts last time out to sit at 4-3 this season. After this game, the Chargers will head on the road for a game against the Tennessee Titans.

Chargers Drop 3 Of Last 4

Justin Herbert has thrown for 1,913 yards, 13 touchdowns and 6 interceptions on 67.5% passing while Omarion Hampton leads Los Angeles in rushing with 314 rushing yards and 2 TDs this season. Keenan Allen leads the Chargers with 44 catches for 435 yards and 4 touchdowns while Quentin Johnston has 28 grabs for 407 yards and 5 TDs. Ladd McConkey’s added 37 catches and 380 receiving yards and 2 TDs and Oronde Gadsden II has 22 catches for 308 yards as well. On defense, Derwin James has a team-high 49 total tackles including a team-high 28 solo tackles. Tuli Tuipulotu has a team-high 5 sacks while the Chargers’ defensive unit as a whole has combined for 17 sacks and 6 interceptions so far this season. 

Minnesota Vikings @ Los Angeles Chargers Betting Trends: Week 8


Why the Los Angeles Chargers will win

  • The Vikings have lost eight of their last nine Thursday road games.
  • The Chargers have won eight of their last nine Week 8 home games.
  • The Vikings have failed to cover the spread in each of their last five games as underdogs following a loss.
  • The Chargers have covered the spread in four of their last five games following a home loss.
  • The home team has won the first quarter in four of the Chargers’ last five games.
  • The favorites have won the first half in each of the Chargers’ last seven Week 8 games.
  • The Chargers have scored the first touchdown in each of their last eight Week 8 games.

Why the Minnesota Vikings will win

  • The Vikings have won each of their last four Week 8 games as road underdogs.
  • The Chargers have lost four of their last five games as favorites against NFC opponents.
  • The Vikings have covered the spread in each of their last eight October games as road underdogs.
  • The Chargers have failed to cover the spread in each of their last four games.
  • The Vikings have won the first quarter in each of their last four October games as road underdogs.
  • The Vikings have won the first half in each of their last four October games as road underdogs.
  • The Vikings have scored the first touchdown in each of their last seven Thursday games.

Total Points Facts

  • Each of the Vikings’ last eight games as underdogs following a home loss have gone OVER the total points line.
  • Seven of the Chargers’ last eight games against NFC opponents have gone UNDER the total points line.
  • Each of the last four Thursday games at SoFi Stadium have gone OVER the total points line.

Los Angeles Chargers Player Prop Facts

  • Keenan Allen has scored at least one touchdown in four of his last five appearances against NFC North opponents.
  • Justin Herbert has recorded 27+ completions in three of the Chargers’ last four games against NFC North opponents.
  • Justin Herbert has recorded 260+ passing yards in each of the Chargers’ last four games against NFC North opponents.
  • Keenan Allen has recorded 58+ receiving yards in each of his last eight appearances at SoFi Stadium.
  • Justin Herbert has recorded 20+ rushing yards in six of the Chargers’ last seven October home games.
  • Ladd McConkey has recorded 58+ rushing and receiving yards in six of the Chargers’ last seven games following a loss.
  • Heading into Week 8, Justin Herbert ranks 1st in the NFL in passing yards (1913) this season.

Minnesota Vikings Player Prop Facts

  • Adam Thielen has scored at least one touchdown in each of his last five October appearances with his team as a road underdog.
  • Adam Thielen has recorded 10+ receiving yards in each of his last 16 appearances with his team as an underdog.
  • Cam Akers has recorded 18+ rushing and receiving yards in each of his last 14 appearances with his team as an underdog.
  • Cam Akers has recorded 15+ rushing yards in each of his last 14 appearances with his team as an underdog.
  • Heading into Week 8, Will Reichard has recorded the equal-most made field goals in a single game this season (5 vs Eagles, Week 7).

Matchup/League Facts

  • Chargers – three different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 8.
  • Chargers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 8.
  • Vikings – three different players have recorded 2.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 8.
  • Heading into Week 8, the Vikings have recorded the largest margin of victory in the NFL this season (38-points vs Cincinnati on September 21, 2025).

Minnesota Vikings vs. Los Angeles Chargers Prediction

I’m leaning towards the Vikings and the points here. I’m not sure who wins this game, and I think whoever does, the points will come into play here. The Chargers have been solid, but something’s off with this team right now since they haven’t been able to instill the ground game with Hampton out, and I think the Vikings could take advantage here and at least keep it close. Give me the points with the Vikings.

Chris Ruffolo's Pick: Minnesota +3

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