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Los Angeles Rams vs Philadelphia Eagles Prediction 9/21/2025 Today’s NFL Picks

Sep 14, 2025; Kansas City, Missouri, USA; Philadelphia Eagles running back Saquon Barkley (26) reacts during the second half against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images

Sep 14, 2025; Kansas City, Missouri, USA; Philadelphia Eagles running back Saquon Barkley (26) reacts during the second half against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images

Los Angeles (2-0) vs Philadelphia (2-0)

September 21, 2025 at 01:00 PM EDT

The Line: Betting Odds: Philadelphia -3 — Over/Under: +44.5

(Get latest betting odds)

The Los Angeles Rams and Philadelphia Eagles meet Saturday in NFL action at Lincoln Financial Field. Here’s a Los Angeles Rams vs Philadelphia Eagles Prediction. This article will include a Los Angeles Rams vs Philadelphia Eagles Pick.

Los Angeles Rams Betting Preview


The Los Angeles Rams beat the Texans and Titans, and they play the Colts next. The Rams have won 11 of their last 14 regular season games. Matthew Stafford is completing 71 percent of his passes for 543 yards, 3 touchdowns, and 1 interception. Puka Nacua and Davante Adams have combined for 378 receiving yards and 1 touchdown, while Jordan Whittington has 2 receptions.

The Los Angeles Rams ground game is averaging 110.5 yards per contest, and Kyren Williams leads the way with 132 yards and 1 touchdown. Defensively, Los Angeles is allowing 14 points and 258.5 yards per game. Nate Landman leads the Los Angeles Rams with 18 tackles, Byron Young has 3 sacks and Cobie Durant has 1 interception.

Philadelphia Eagles Betting Preview


The Philadelphia Eagles beat the Cowboys and Chiefs, and they play the Buccaneers next. The Philadelphia Eagles have won 14 of their last 15 regular season games. Jalen Hurts is completing 75.6 percent of his passes for 253 yards, 0 touchdowns, and 0 interceptions. DeVonta Smith and Jahan Dotson have combined for 132 receiving yards on 11 catches, while Dallas Goedert has 7 receptions.

The Philadelphia Eagles ground game is averaging 140 yards per contest, and Saquon Barkley leads the way with 148 yards and 2 touchdowns. Defensively, Philadelphia is allowing 18.5 points and 300.5 yards per game. Zack Baun leads the Philadelphia Eagles with 15 tackles, Moro Ojomo has 1 sack and Andrew Mukuba has 1 interception.

Los Angeles Rams @ Philadelphia Eagles Betting Trends: Week 3


Why the Philadelphia Eagles will win

  • The Eagles have won 16 of their last 17 games at Lincoln Financial Field against teams that held a winning record.
  • The Rams have lost each of their last four games against NFC East opponents on a winning streak.
  • The Eagles have covered the spread in five of their last six Sunday games at Lincoln Financial Field.
  • The Rams have failed to cover the spread in five of their last six September games as road underdogs.
  • The Rams have lost the first quarter in five of their last six September road games against NFC East opponents.
  • The Rams have lost the first half in each of their last six games in September.

Why the Los Angeles Rams will win

  • The Rams have won each of their last five Week 3 games against NFC opponents.
  • The Eagles have lost each of their last four September games against NFC West opponents.
  • The Rams have covered the spread in each of their last seven Sunday games.
  • The Eagles have failed to cover the spread in each of their last four September games against NFC West opponents.
  • The Eagles have lost the first quarter in each of their last two September games as favorites against NFC West opponents.

Total Points Facts

  • Each of the Rams’ last four Sunday games as underdogs have gone OVER the total points line.
  • Five of the Eagles’ last six September games at Lincoln Financial Field have gone UNDER the total points line.

Philadelphia Eagles Player Prop Facts

  • Saquon Barkley has scored two or more touchdowns in three of the Eagles’ last four games as favorites against teams with a winning record.
  • Jalen Hurts has scored at least one touchdown in each of the Eagles’ last seven games as favorites following a road win.
  • AJ Dillon has scored the first touchdown in three of his last four appearances with his team as a home favorite against NFC West opponents.
  • Saquon Barkley has recorded 118+ rushing yards in eight of his last nine appearances against NFC opponents.
  • Jalen Hurts has recorded 230+ passing yards in three of his last four Sunday regular season home appearances.
  • Dallas Goedert has recorded 44+ receiving yards in each of his last six appearances at Lincoln Financial Field.
  • Dallas Goedert has recorded 44+ rushing and receiving yards in each of his last six appearances with the Eagles as home favorites.
  • Heading into Week 3, Jalen Hurts ranks T1st in the NFL in rushing touchdowns (3) this season.

Los Angeles Rams Player Prop Facts

  • Kyren Williams has scored at least one touchdown in each of the Rams’ last six September games against NFC opponents.
  • Kyren Williams has recorded 76+ rushing yards in seven of his last eight appearances with the Rams as underdogs against NFC opponents.
  • Matthew Stafford has recorded 249+ passing yards in seven of his eight previous Week 3 road appearances.
  • Tyler Higbee has recorded 20+ receiving yards in 12 of his last 13 appearances against NFC East opponents.
  • Kyren Williams has recorded 92+ rushing and receiving yards in eight of his last nine appearances with the Rams as underdogs.
  • Davante Adams has scored the first touchdown in three of his four previous appearances against the Eagles.
  • Matthew Stafford has recorded 23+ completions in each of his last four Sunday appearances with the Rams as underdogs.
  • Heading into Week 3, Byron Young has recorded the equal-most sacks in a single game this season (2 vs Titans, Week 2).

Matchup/League Facts

  • Eagles – one different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
  • Heading into Week 3, the Eagles rank 32nd in the NFL in average kickoff return (20.2 yards) this season.
  • Rams – two different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 3.
  • Rams – six different players have recorded 1.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 3.

Los Angeles Rams vs Philadelphia Eagles Prediction


The Eagles have been a fantastic regular season team dating back to last season so they’re going to get the benefit of doubt at home. However, the Eagles have been a bit underwhelming through 2 games, as both games have come down to the wire, and they have yet to get their passing attack going.

I’m a huge fan of Sean McVay, and like backing him in the underdog role, as I believe he gives his team a chance to win each week. In fact, the Rams have covered 10 of their last 14 games as an underdog. Six of those covers were outright wins. The Rams have a top-five passing defense and total defense, so this doesn’t feel like a spot where the Eagles get going. Give me the points.

Randy Chambers's Pick: Los Angeles Rams +3

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