Los Angeles Rams vs Denver Broncos Prediction 9/27/2026 Today’s NFL Picks

Andrew Jett

1 hour ago

MATCHUP	Los Angeles Rams	Denver Broncos
Team Records	1-1	1-1
Spread	-2.5 -110	+2.5 -110
Moneyline	-135	+114
Total	Over 43.5 (-115)	Under 43.5 (-105)
Where	Empower Field at Mile High, Denver, CO
When	Sunday, September 27, 2026
Time	08:20 PM EDT
TV	NBC

The Los Angeles Rams and the Denver Broncos meet Sunday in NFL action from Empower Field at Mile High in Denver. Here’s a Rams vs Broncos prediction. We will look at this from a betting perspective and determine the best Rams vs Broncos pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Los Angeles Rams Betting Preview

LA opened up their season with a home game versus the San Francisco 49ers back on September 10. In that one the Rams were only down by three points 10-7 at the break. Los Angeles couldn’t score from there however, and ended up losing 27-7. QB Matthew Stafford was 15-of-25 for 155 yards and a pick. Puka Nacua caught five balls for 74 yards as well.

In the Monday night game versus the New York Giants, Los Angeles scored a couple of touchdowns in the first half and went into the break up 14-3. The Rams bagged a couple more trips to the end zone from there and won 28-6. Stafford was 22-of-31 for 327 yards and all four touchdowns with one pick.

Denver Broncos Betting Preview

Over on the Broncos’ side, they played the Kansas City Chiefs in a road matchup for their opener. Denver gave up points in every quarter along the way to a 31-10 loss in the end. QB Bo Nix was 17-of-28 for 131 yards, one TD and one pick. Evan Engram led the receivers with four grabs for 43 yards and a score, while JK Dobbins had eight carries for 36 yards.

Matched up against the Jacksonville Jaguars last weekend, the Broncos were in trouble with a 13-6 deficit heading into the fourth quarter. Denver managed to score a pair of unanswered touchdowns in that frame however, leading to a 20-13 comeback home win. Nix logged 288 yards, one TD and one interception on a 22-of-31 line and Jaylen Waddle had eight catches for 138 yards.

Los Angeles Rams @ Denver Broncos Betting Trends: Week 3

Why the Denver Broncos will win

The Broncos have won each of their last eight September home games against NFC West opponents.
The Rams have lost four of their last five games without Matthew Stafford.
The home team has covered the spread in each of the Broncos’ last six games.
The Rams have failed to cover the spread in five of their last six road games in September.
The home team has won the first half in eight of the last 10 games between the Rams and Broncos.

Why the Los Angeles Rams will win

The Rams have won 23 of their last 24 Sunday games as favorites.
The Broncos have lost three of their last four games without Nik Bonitto.
The Rams have covered the spread in each of their last seven games as favorites against AFC opponents.
The Broncos have failed to cover the spread in three of their last four games without Jonathon Cooper.
The Rams have won the first half in each of their last five games against the Broncos.
The Broncos have lost the first quarter in three of their last four Week 3 games against NFC opponents.

Total Points Facts

Ten of the Broncos’ last 11 September games at Empower Field at Mile High have gone UNDER the total points line.
Seven of the Rams’ last eight road games have gone OVER the total points line.

Denver Broncos Player Prop Facts

Troy Franklin has scored at least one touchdown in each of the Broncos’ last four home games against NFC opponents.
Troy Franklin has recorded 19+ receiving yards in each of his last eight appearances with the Broncos as underdogs following a win.
J.K. Dobbins has recorded 61+ rushing yards in each of his four previous appearances following a home win.
Bo Nix has recorded 247+ passing yards in each of the Broncos’ last five home games against NFC opponents.
Jaylen Waddle has recorded 72+ rushing and receiving yards in five of his last six Sunday appearances with his team as a home underdog.
Jarrett Stidham has recorded four or more completions in each of his four previous appearances with his team as a home underdog.
Heading into Week 3, Zach Allen has recorded the equal-most sacks in a single game this season (2.0 vs Chiefs, Week 1).

Los Angeles Rams Player Prop Facts

Matthew Stafford has recorded 243+ passing yards in each of the Rams’ last nine games as favorites following a home win.
Tutu Atwell has recorded 10+ rushing and receiving yards in each of the Rams’ last five games against AFC West opponents.
Kyren Williams has scored at least one touchdown in each of the Rams’ last five games.
Tyler Higbee has recorded 13+ receiving yards in each of his last nine Sunday appearances with the Rams as favorites.
Kyren Williams has recorded 66+ rushing yards in seven of the Rams’ last eight September games.
Matthew Stafford has recorded 23+ completions in seven of the Rams’ last eight games following a home win.
Heading into Week 3, Davante Adams has recorded the most receiving yards in a single game this season (195 vs Giants, Week 2).

Matchup/League Facts

Heading into Week 3, the Broncos rank 29th in the NFL in rushing yards allowed per game (157.5) this season.
Heading into Week 3, the Broncos rank 29th in the NFL in 3rd down percentage (26.1%) this season.
Rams – two different players have recorded 70+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
Heading into Week 3, the Rams have recorded the largest single-game yard differential this season (299 vs New York Giants in Week 2).

Rams vs Broncos Prediction

I’ll go with Denver. I’d like to see the Broncos get it moving a little earlier in the game, though. Denver ended up with 10 penalties for 53 yards and a sketchy 4-of-11 on third downs in their comeback win over the Jaguars last weekend. On defense the Broncos gave up just 268 yards and 5-of-12 on third-down tries, so it was a pretty nice effort overall from that unit. This being another home game will help Denver out a lot.

As for the Rams, they got back to business against the overmatched Giants, posting 481 yards, 8.0 yards per play and 5-of-9 on third downs in their Monday night win. LA gave up just 182 yards on the other side with 11 first downs and 3-of-14 on third downs. If there’s a gripe it’s the two turnovers but other than that there wasn’t much to complain about. If Denver’s offense can get it going early this matchup will be very interesting.