Los Angeles Chargers vs Seattle Seahawks Prediction 10/4/2026 Today’s NFL Picks
Chris Ruffolo
Sep 20, 2026; Glendale, Arizona, USA; Seattle Seahawks quarterback Drew Lock (2) hands off the ball to running back Emanuel Wilson (23) in the third quarter against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images
MATCHUP
Los Angeles Chargers
Seattle Seahawks
Team Records
0-3
2-1
Spread
+7 -105
-7 -115
Moneyline
+295
-375
Total
Over 42.5 (-118)
Under 42.5 (-102)
Where
Lumen Field, Seattle, WA
When
Sunday, October 4, 2026
Time
04:25 PM EDT
TV
CBS
The Los Angeles Chargers and the Seattle Seahawks meet in week 4 NFL action from Lumen Field on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Los Angeles Chargers vs. Seattle Seahawks prediction.
Los Angeles Chargers Recap
The Los Angeles Chargers come into this game looking to bounce back from a 24-16 loss at the hands of Buffalo last time out to sit at 0-3 this season. After this game, the Chargers will head home for a game against the Denver Broncos.
Chargers Looking For First Win
Justin Herbert has thrown for 627 yards, 3 touchdowns and 4 interceptions on 59.1% passing while Omarion Hampton leads Los Angeles in rushing with 193 yards and 2 touchdowns through 3 games this season. Keaton Mitchell sits behind Hampton on the ground with 85 yards and 0 TDs. Ladd McConkey leads the Chargers in receiving with 183 yards and 12 catches along with 1 TD, while Tre’ Harris trails with 149 yards and 10 catches. On defense, Derwin James Jr. has a team-high 21 tackles while Los Angeles’s defense as a whole has combined for 7 sacks and 3 interceptions through 3 games this season.
Seattle Seahawks Recap
The Seattle Seahawks come into this game looking to bounce back from a 33-31 loss at the hands of Washington last time out to sit at 2-1 this season. After this game, the Seahawks will take on the San Francisco 49ers in a matchup at home.
Seahawks Take First L Of Season
Drew Lock has thrown for 422 yards, 4 touchdowns and 0 interceptions on 72.9% passing while Jadarian Price leads Seattle in rushing with 119 yards and 0 touchdowns through 3 games this season. Emanuel Wilson sits behind Price on the ground with 109 yards and 0 TDs. Jaxon Smith-Njigba leads the Seahawks in receiving with 405 yards and 27 catches along with 6 TDs, while Cooper Kupp trails with 101 yards and 8 catches. On defense, Ernest Jones IV has a team-high 29 tackles while Seattle’s defense as a whole has combined for 7 sacks and 4 interceptions through 3 games this season.
Los Angeles Chargers @ Seattle Seahawks Betting Trends: Week 4
Why the Seattle Seahawks will win
The Seahawks have won each of their last nine games played on the West Coast.
The Chargers have lost each of their last six games.
The Chargers have failed to cover the spread in each of their last six games.
The Seahawks have covered the spread in each of their last four home games against teams that held a losing record.
The Seahawks have won the first quarter in each of their last six Week 4 games as favorites.
The Seahawks have scored the first touchdown in each of their last seven home games against AFC West opponents.
The Seahawks have won the first half in each of their last five home games against teams that held a losing record.
Why the Los Angeles Chargers will win
The Chargers have won each of their last three games as underdogs against NFC opponents.
The Seahawks have lost six of their last nine games as home favorites following a loss.
The Chargers have covered the spread in each of their last nine games as road underdogs against NFC opponents.
The Seahawks have failed to cover the spread in seven of their last eight games as favorites without Uchenna Nwosu.
The Chargers have won the first quarter in six of their last eight games as underdogs against reigning Super Bowl champions.
The Chargers have scored the first touchdown in each of their last four games played as underdogs on the West Coast.
The Chargers have won the first half in each of their last seven games as road underdogs against NFC opponents.
Total Points Facts
Each of the Chargers’ last six games have gone UNDER the total points line.
Each of the Seahawks’ last five Week 4 games as favorites have gone UNDER the total points line.
Seattle Seahawks Player Prop Facts
Jaxon Smith-Njigba has scored two touchdowns in three of the Seahawks’ last four games against teams that held a losing record.
Cooper Kupp has recorded 29+ receiving yards in each of his last 14 October appearances with his team as a favorite.
Sam Darnold has recorded 240+ passing yards in each of his last six appearances following a loss.
Jaxon Smith-Njigba has scored a touchdown in each of the Seahawks’ last six October games as favorites.
Cooper Kupp has recorded 29+ rushing and receiving yards in each of his last 14 October appearances with his team as a favorite.
Drew Lock has recorded 21+ completions in six of his last eight appearances as a starter.
Heading into Week 4, Jaxon Smith-Njigba ranks 1st in the NFL in receiving yards (405) this season.
Los Angeles Chargers Player Prop Facts
Omarion Hampton has scored a touchdown in each of the Chargers’ last four games played on the West Coast.
Quentin Johnston has recorded 40+ receiving yards in eight of his last nine regular season road appearances.
Justin Herbert has recorded 228+ passing yards in each of the Chargers’ last six October road games.
Justin Herbert has recorded 24+ rushing yards in each of the Chargers’ last six games against NFC opponents.
Justin Herbert has recorded 19+ completions in each of his eight previous road appearances on the West Coast.
Quentin Johnston has recorded 40+ rushing and receiving yards in eight of his last nine regular season road appearances.
Heading into Week 4, Genesis Smith has recorded the equal-most interceptions in a single game this season (2 vs Bills, Week 3).
Matchup/League Facts
Heading into Week 4, the Seahawks rank 1st in the NFL in yards allowed per game (228.7) this season.
Heading into Week 4, the Seahawks rank 1st in the NFL in passing yards allowed per game (141.7) this season.
Heading into Week 4, the Chargers rank 32nd in the NFL in Q4 points per game (1.0) this season.
Heading into Week 4, the Chargers rank T1st in the NFL in Q3 win percentage (66.7) this season.
Los Angeles Chargers vs. Seattle Seahawks Prediction
I’m on the Seahawks in this one. I get the case to be made for either side in this game as the Chargers are in desperation mode for a win with a gauntlet of games ahead, but the problem is that they’re just not playing well and keep finding new and creative ways to lose football games. The Chargers forced 5 turnovers against the Bills and still couldn’t do enough to get the win in the end. I think the Seahawks smack the Chargers around and get the bounce back win and cover so give me Seattle here.
