Los Angeles Chargers vs Jacksonville Jaguars Prediction 11/16/2025 Today’s NFL Picks
Chris Ruffolo
Nov 9, 2025; Inglewood, California, USA; Los Angeles Chargers quarterback Justin Herbert (10) passes the ball against the Pittsburgh Steelers during the fourth quarter of the game at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images
MATCHUP
Los Angeles Chargers
Jacksonville Jaguars
Team Records
7-3
5-4
Spread
-3 -102
+3 -118
Moneyline
-155
+130
Total
Over 43.5 (-115)
Under 43.5 (-105)
Where
EverBank Stadium, Jacksonville, FL
When
Sunday, November 16, 2025
Time
01:00 PM EST
TV
CBS
The Los Angeles Chargers and the Jacksonville Jaguars meet in week 11 NFL action from EverBank Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Chargers vs. Jacksonville Jaguars prediction.
Los Angeles Chargers Recap
The Los Angeles Chargers come into this game looking to add on to their 25-10 win over the Pittsburgh Steelers last time out to sit at 7-3 this season. After this game, the Chargers will head home for a game against the Las Vegas Raiders.
Chargers Win 3 In A Row
Justin Herbert has thrown for 2,610 yards, 19 touchdowns and 8 interceptions on 67% passing while Kimani Vidal also has 404 rushing yards and 2 TDs as well this season. Ladd McConkey leads the Chargers with 631 receiving yards coming on 51 catches with 4 TDs while Keenan Allen has a team-high 52 catches for 539 yards and 4 TDs. Quentin Johnston has 502 receiving yards with 6 TDs and Oronde Gadsden II has 35 catches for 466 yards as well. On defense, Daiyan Henley has a team-high 67 total tackles including 35 solo tackles. Tuli Tuipulotu has a team-high 8 sacks while the Chargers’ defensive unit as a whole has combined for 29 sacks and 9 interceptions so far this season.
Jacksonville Jaguars Recap
The Jacksonville Jaguars come into this game looking to rebound from a 36-29 loss at the hands of the Houston Texans last time out to slip to 5-4 this season. After this game, Jacksonville will head on the road for a game against Arizona.
Jaguars Drop 3 Of Last 4
Trevor Lawrence has thrown for 1,998 yards, 10 touchdowns and 7 interceptions on 59.5% passing while Travis Etienne Jr. leads the Jaguars on the ground with 656 rushing yards and 3 touchdowns. Brian Thomas Jr. has a team-high 30 catches for 420 yards and a touchdown while Travis Hunter has 298 receiving yards and Parker Washington has 330 receiving yards as well this season. Dyami Brown and Brenton Strange each have 200+ receiving yards as well on the year. On defense, Foyesade Oluokun has a team-high 75 total tackles while Devin Lloyd has a team-high 4 interceptions. Arik Armstead also has 4.5 sacks to lead the Jaguars. Jacksonville’s defense as a whole has combined for 12 sacks and 12 interceptions so far this season.
Los Angeles Chargers @ Jacksonville Jaguars Betting Trends: Week 11
Why the Jacksonville Jaguars will win
The Jaguars have won each of their last three November games as home underdogs against AFC opponents.
The Chargers have lost three of their last four games as road favorites against AFC South opponents.
The Jaguars have covered the spread in nine of their last 10 games as underdogs following a road loss.
The Chargers have failed to cover the spread in each of their last four road games against AFC South opponents.
The Jaguars have scored the first touchdown in each of their last five Sunday games at EverBank Stadium.
The Chargers have lost the first quarter in each of their last four games as favorites against AFC opponents.
The Jaguars have won the first half in each of their four previous Week 11 games against AFC West opponents.
Why the Los Angeles Chargers will win
The Chargers have won seven of their last eight November games against AFC South opponents.
The Jaguars have lost 13 of their last 14 games against teams that held a winning record.
The Jaguars have failed to cover the spread in each of their last seven Week 11 games as underdogs.
The favorites have covered the spread in nine of the Jaguars’ last 10 Week 11 games.
The Chargers have won the first quarter in each of their last eight Week 11 games.
The Jaguars have lost the first half in 22 of their last 23 games as underdogs against AFC West opponents.
Total Points Facts
Each of the Chargers’ last six games as favorites against the Jaguars have gone OVER the total points line.
Each of the Jaguars’ last six games as underdogs following a road loss have gone UNDER the total points line.
Each of the last four Sunday games at EverBank Stadium have gone UNDER the total points line.
Jacksonville Jaguars Player Prop Facts
Trevor Lawrence has scored at least one touchdown in four of his last five November appearances.
Trevor Lawrence has recorded 24+ rushing yards in each of his last five regular season appearances against AFC West opponents.
Trevor Lawrence has recorded 216+ passing yards in each of his last seven appearances against AFC West opponents.
Trevor Lawrence has recorded 22+ completions in six of his last seven appearances against AFC West opponents.
Jakobi Meyers has recorded 42+ receiving yards in each of his last nine appearances against AFC West opponents.
Jakobi Meyers has recorded 42+ rushing and receiving yards in each of his last nine appearances against AFC West opponents.
Heading into Week 11, Devin Lloyd ranks T1st in the NFL in interceptions (4) this season.
Los Angeles Chargers Player Prop Facts
Justin Herbert has scored a touchdown in each of the Chargers’ last two November games against AFC South opponents.
Justin Herbert has recorded 260+ passing yards in each of the Chargers’ last five Week 11 games.
Justin Herbert has recorded 24+ rushing yards in four of the Chargers’ last five regular season road games.
Justin Herbert has recorded 24+ completions in eight of the Chargers’ last 10 regular season games against AFC South opponents.
Will Dissly has recorded 18+ receiving yards in eight of his last 10 regular season appearances against AFC opponents.
Heading into Week 11, Cameron Dicker ranks 1st in the NFL in made field goals (23) this season.
Matchup/League Facts
Jaguars – eight different players have recorded one interception or more in a game this season – equal-most in the NFL, heading into Week 11.
Heading into Week 11, the Jaguars have given up the equal largest lead to win a game this season – 19 points vs Texans.
Chargers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 11.
Chargers – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 11.
Los Angeles Chargers vs. Jacksonville Jaguars Prediction
I’m on the Chargers here. I just trust this Charger defense a lot more right now, as we just saw Jacksonville get picked apart by Davis Mills of all people. The Chargers are also the much healthier team as the Jaguars are missing a couple of top receivers and this team is just banged up all over the place. I think the Chargers get it done here. Give me the Chargers.
