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Kansas City Chiefs vs Jacksonville Jaguars Prediction 10/6/2025 Today’s NFL Picks

Sep 28, 2025; Santa Clara, California, USA; Jacksonville Jaguars running back Travis Etienne (1) reacts after scoring a touchdown against the San Francisco 49ers during the second quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

Sep 28, 2025; Santa Clara, California, USA; Jacksonville Jaguars running back Travis Etienne (1) reacts after scoring a touchdown against the San Francisco 49ers during the second quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

MATCHUP Kansas City Chiefs Jacksonville Jaguars
Team Records 2-2 3-1
Where EverBank Stadium, Jacksonville, FL
When Monday, October 6, 2025
Time 08:15 PM EDT
TV ABC

The Kansas City Chiefs and Jacksonville Jaguars meet Monday in NFL action at EverBank Stadium. Here’s a Kansas City Chiefs vs Jacksonville Jaguars Prediction. This article will include a Kansas City Chiefs vs Jacksonville Jaguars Pick.

Kansas City Chiefs Betting Preview

The Kansas City Chiefs beat the Giants and Ravens, and they play the Lions next. The Kansas City Chiefs have lost 3 of their last 5 regular season games. Patrick Mahomes is completing 61.3 percent of his passes for 939 yards, 7 touchdowns, and 1 interception. Hollywood Brown and Travis Kelce have combined for 391 receiving yards and 2 touchdowns, while Tyquan Thornton has 10 receptions.

The Kansas City Chiefs ground game is averaging 110.5 yards per contest, and Patrick Mahomes leads the way with 130 yards and 2 touchdowns. Defensively, Kansas City is allowing 19 points and 312.8 yards per game. Nick Bolton leads the Kansas City Chiefs with 34 tackles, George Karlaftis has 3 sacks and Chris Roland-Wallace has 1 interception.

Jacksonville Jaguars Betting Preview

The Jacksonville Jaguars beat the Texans and 49ers, and they play the Seahawks next. The Jacksonville Jaguars have won 4 of their last 6 games. Trevor Lawrence is completing 58.3 percent of his passes for 845 yards, 5 touchdowns, and 4 interceptions. Brenton Strange and Brian Thomas Jr. have combined for 346 receiving yards on 31 catches, while Travis Hunter has 13 receptions.

The Jacksonville Jaguars ground game is averaging 144 yards per contest, and Travis Etienne Jr. leads the way with 394 yards and 2 touchdowns. Defensively, Jacksonville is allowing 18 points and 316.3 yards per game. Foyesade Oluokun leads the Jacksonville Jaguars with 30 tackles, Arik Armstead has 2.5 sacks and Devin Lloyd has 3 interceptions.

Kansas City Chiefs @ Jacksonville Jaguars Betting Trends: Week 5

Why the Jacksonville Jaguars will win

Why the Kansas City Chiefs will win

Total Points Facts

Jacksonville Jaguars Player Prop Facts

Kansas City Chiefs Player Prop Facts

Matchup/League Facts

Kansas City Chiefs vs Jacksonville Jaguars Prediction

The Jaguars are off to a fine start through 4 games with an improved defense and an offense that’s running the ball at a high level. The Jags will be up for this game as it’s a statement matchup. However, it feels like oddsmakers aren’t that high on the Chiefs, but they’ve shown flashes lately and should’ve turned heads against the Ravens. Mahomes looks like an MVP candidate through 4 games, and the Chiefs’ defense is top-10 in scoring defense and against the pass. I’d argue this line is soft, as I like what the Chiefs have done recently, and I’m still not there with the Jaguars. I’ll lay the field goal with the road team.

Randy Chambers's Pick: Kansas City Chiefs -3

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