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Indianapolis Colts vs Pittsburgh Steelers Prediction 11/2/2025 Today’s NFL Picks

Sep 29, 2024; Indianapolis, Indiana, USA; Indianapolis Colts defensive end Tyquan Lewis (94) and linebacker E.J. Speed (45) sack Pittsburgh Steelers quarterback Justin Fields (2) during the second half at Lucas Oil Stadium. Mandatory Credit: Marc Lebryk-Imagn Images

Sep 29, 2024; Indianapolis, Indiana, USA; Indianapolis Colts defensive end Tyquan Lewis (94) and linebacker E.J. Speed (45) sack Pittsburgh Steelers quarterback Justin Fields (2) during the second half at Lucas Oil Stadium. Mandatory Credit: Marc Lebryk-Imagn Images

MATCHUP Indianapolis Colts Pittsburgh Steelers
Team Records 7-2 5-3
Where Acrisure Stadium, Pittsburgh, PA
When Sunday, November 2, 2025
Time 01:00 PM EST
TV CBS

In this article, we will formulate a Panthers vs Packers Prediction for this NFL Week 9 game on Sunday, November 2nd. Let’s take a look at the prediction for this NFL matchup.

Pittsburgh Steelers Preview

The Pittsburgh Steelers have a 4-3 record this season and are sitting first in the AFC North. They are 3-4 ATS, 5-2 in Over/Under and have a 2-2 home record and a 2-1 away record. The Steelers are coming off a 25-35 home loss against the Green Bay Packers and will face the Chargers, Bengals and Bears next.

Offensively, the Steelers average 25.0 points per game, ranking 11th in the NFL, while defensively, they allow 25.0 points per game, which is 22nd. Pittsburgh averages 297.1 total yards per game (202.9 passing and 94.3 rushing), while allowing 386.0 total yards per game (112.7 rushing and 273.3 passing).

Aaron Rodgers leads the Steelers with 1489 passing yards with 68.3% completed passes and 16 touchdowns. Jaylen Warren leads the team in rushing yards with 373, while D.K. Metcalf has a team-high 27 receptions for 461 receiving yards, and five touchdowns. Defensively, Payton Wilson has a team-high 57 total tackles (35 of them solo), while T.J. Watt leads the team in sacks, with 4.0. Jalen Ramsey, DeShon Elliott, Brandin Echols and Nick Herbig each have one interception.

Indianapolis Colts Preview

The Indianapolis Colts have a 7-1 record this season and are sitting first in the AFC South. They are 6-2 ATS, 5-3 in Over/Under and have a 5-0 home record and a 2-1 away record. The Colts are coming off a 38-14 home win against the Tennessee Titans and will face the Falcons, Chiefs and Texans next.

Offensively, the Colts average 33.8 points per game, ranking 1st in the NFL, while defensively, they allow 19.3 points per game, which is 6th. Indianapolis averages 385.3 total yards per game (250.9 passing and 134.4 rushing), while allowing 345.1 total yards per game (93.1 rushing and 252.0 passing).

Daniel Jones leads the Colts with 2062 passing yards with 71.2% completed passes and 13 touchdowns. Jonathan Taylor leads the team in rushing yards with 850, while Tyler Warren has a team-high 37 receptions for 492 receiving yards, and three touchdowns. Defensively, Nick Cross has a team-high 56 total tackles (35 of them solo), while DeForest Buckner leads the team in sacks, with 4.0. Camryn Bynum, Nick Cross, Laiatu Latu, Mekhi Blackmon, Kenny Moore, Chris Lammons and Grover Stewart each have one interception.

Indianapolis Colts @ Pittsburgh Steelers Betting Trends: Week 9

Why the Pittsburgh Steelers will win

Why the Indianapolis Colts will win

Total Points Facts

Pittsburgh Steelers Player Prop Facts

Indianapolis Colts Player Prop Facts

Matchup/League Facts

Colts vs Steelers Prediction

In their previous meeting last season, the Colts won 27-24 at home, but they are 2-8 in their last 10 meetings against the Steelers, having lost their last four visits in Pittsburgh. Over is 8-2 in their last 10 meetings.      

In this Colts vs Steelers Prediction, the Colts are coming as -3-point road favorites, with the total set at 50.5 points. Both teams are coming into this matchup in opposite trajectories, as the Steelers have dropped back-to-back games, while the Colts have been red-hot with four consecutive wins. The Colts have been the superior team, having the best offense in the NFL and the 6th-best defense, with a +14.5 point differential and I expect them to take care of business in this one. Take the Colts and lay the -3 points on the road.

Nikos Lagouretos's Pick: Indianapolis Colts -4

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