Houston Texans vs Los Angeles Chargers Prediction 12/27/2025 Today’s NFL Picks
Chris Ruffolo
Dec 21, 2025; Houston, Texas, USA; Houston Texans quarterback C.J. Stroud (7) passes against the Las Vegas Raiders during the first quarter at NRG Stadium. Mandatory Credit: Troy Taormina-Imagn Images
MATCHUP
Houston Texans
Los Angeles Chargers
Team Records
10-5
11-4
Spread
+1.5 -105
-1.5 -115
Moneyline
+110
-130
Total
Over 39.5 (-108)
Under 39.5 (-112)
Where
SoFi Stadium, Inglewood, CA
When
Saturday, December 27, 2025
Time
04:30 PM EST
TV
NFL Net
The Houston Texans and the Los Angeles Chargers meet in week 17 NFL action from SoFi Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Texans vs. Los Angeles Chargers prediction.
Houston Texans Recap
The Houston Texans come into this game looking to add on to their 23-21 win over the Las Vegas Raiders last time out to sit at 10-5 this season. After this game, Houston will head home for their regular season finale against the Indianapolis Colts.
Texans Win 7 In A Row
C.J. Stroud has 2,628 yards, 16 touchdowns and 6 interceptions on 65.3% passing while Davis Mills has thrown for 879 yards, 5 TDs and an INT on 58.7% passing. Nick Chubb has rushed for 505 yards and 3 touchdowns as well this season. Woody Marks also has 584 rushing yards and 2 TDs while Nico Collins leads Houston’s receivers with 1,060 receiving yards and 6 TDs and Dalton Schultz has 75 grabs for 685 yards. Xavier Hutchinson has 323 receiving yards and 3 TDs and Jayden Higgins has 414 receiving yards as well this season. Three more Texans have 200+ receiving yards as well this season. On defense, Azeez Al-Shaair leads the Texans with 96 total tackles while Jalen Pitre has 4 INTs and Will Anderson Jr. has 11.5 sacks. Danielle Hunter also has 13 sacks while Calen Bullock has 4 interceptions and Derek Stingley Jr. and has 4 interceptions as well this season. As a unit, Houston’s defense has combined for 41 sacks and 17 interceptions up to this point in the year.
Los Angeles Chargers Recap
The Los Angeles Chargers come into this game looking to add on to their 34-17 win over Dallas last time out to sit at 11-4 this season. After this game, Los Angeles will head on the road for their season finale against the Denver Broncos.
Chargers Win 4th Straight
Justin Herbert has thrown for 3,491 yards, 25 touchdowns and 12 interceptions on 66.5% passing while Kimani Vidal also has 631 rushing yards and 3 TDs as well this season. Omarion Hampton has 516 rushing yards and Ladd McConkey leads the Chargers with 758 receiving yards coming on 65 catches with 6 TDs while Keenan Allen has a team-high 73 catches for 724 yards and 4 TDs. Quentin Johnston has 637 receiving yards with 8 TDs and Oronde Gadsden II has 44 catches for 609 yards as well. On defense, Daiyan Henley has a team-high 92 total tackles including 52 solo tackles. Tuli Tuipulotu has a team-high 13 sacks while Donte Jackson and Tony Jefferson each have a team-high 4 interceptions. As a group, the Chargers’ defensive unit has combined for 41 sacks and 17 interceptions so far this season.
Houston Texans @ Los Angeles Chargers Betting Trends: Week 17
Why the Los Angeles Chargers will win
The favorites have won each of the Chargers’ last 13 Week 17 games.
The Texans have lost each of their six previous Week 17 road games.
The favorites have covered the spread in each of the Chargers’ last nine Week 17 games.
The Texans have failed to cover the spread in each of their last five games played on the West Coast.
The home team has won the first quarter in four of the Chargers’ last five games.
The favorites have won the first half in each of the Chargers’ last 11 Week 17 games.
The Chargers have scored the first touchdown in seven of their last eight games played on the West Coast.
Why the Houston Texans will win
The Texans have won each of their last seven games without Jimmie Ward.
The Chargers have lost three of their last four games as favorites against AFC South opponents.
The Texans have covered the spread in seven of their last eight road games without Nico Collins.
The Chargers have failed to cover the spread in each of their last four games against AFC South opponents.
The Chargers have lost the first quarter in each of their last five games as favorites following a win.
The Chargers have lost the first half in seven of their last eight December games against AFC opponents.
Total Points Facts
Each of the Texans’ last four games in California have gone UNDER the total points line.
Six of the Chargers’ last seven games against AFC South opponents have gone OVER the total points line.
Los Angeles Chargers Player Prop Facts
Ladd McConkey has scored a touchdown in four of the Chargers’ last five games as home favorites.
Ladd McConkey has recorded 43+ receiving yards in eight of his nine previous appearances following a road win.
Ladd McConkey has recorded 43+ rushing and receiving yards in eight of his nine previous appearances following a road win.
Heading into Week 17, Cameron Dicker ranks T2nd in the NFL in made field goals (36) this season.
Houston Texans Player Prop Facts
C.J. Stroud has recorded 22+ completions in eight of his last 10 appearances.
C.J. Stroud has recorded 229+ passing yards in five of his last six appearances with the Texans as underdogs following a win.
Christian Kirk has recorded 25+ receiving yards in each of his last 11 appearances on the West Coast.
Christian Kirk has recorded 25+ rushing and receiving yards in each of his last 11 appearances on the West Coast.
Joe Mixon has scored at least one touchdown in six of his last seven road appearances against teams that held a winning record.
Joe Mixon has recorded 72+ rushing yards in each of his last five appearances on the West Coast.
Heading into Week 17, Calen Bullock has recorded the equal-most interceptions in a single game this season (2 vs Bills, Week 12).
Matchup/League Facts
Chargers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 17.
Chargers – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 17.
Heading into Week 17, the Texans rank 1st in the NFL in points allowed per game (16.6) this season.
Heading into Week 17, the Texans rank 1st in the NFL in yards allowed per game (272.3) this season.
Houston Texans vs. Los Angeles Chargers Prediction
I’m on Houston here. I just think this is a game where no matter who was favored, I’d want to be on the underdog, as this to me feels like it’s going to be a defensive battle. These two teams are legit offensively, but I also think that the Texans have the healthier offensive line in this game and in the end I expect that to be the difference as Houston bags the cover and potential outright win here. Give me Houston.
