| MATCHUP | Detroit Lions | Arizona Cardinals |
|---|---|---|
| Team Records | 2-2 | 1-3 |
| Spread | -5.5 -110 | +5.5 -110 |
| Moneyline | -265 | +215 |
| Total | Over 54.5 (-115) | Under 54.5 (-105) |
| Where | State Farm Stadium, Glendale, AZ | |
| When | Sunday, October 11, 2026 | |
| Time | 04:25 PM EDT | |
| TV | Fox | |
Arizona Cardinals Preview
The Arizona Cardinals have a 1-3 record this season are sitting on the 4th place of the NFC West. They are coming off a 24-36 away loss against the Giants and will face the Rams, the Broncos and the Cowboys next.
Offensively, the Cardinals average 21.8 points per game, ranking 17th in the NFL, while defensively, they allow 29.3 points per game, which is 29th. Arizona averages 294.8 total yards per game (194.3 passing and 100.5 rushing), while allowing 351.3 total yards per game (117.5 rushing and 233.8 passing).
Jacoby Brissett leads the Cardinals with 818 passing yards with 67.8% completed passes and six touchdowns. Jeremiyah Love leads the team in rushing yards with 223, while Michael Wilson has 25 receptions for a team-high 258 receiving yards. Defensively, Jack Gibbens has a team-high 32 total tackles (13 of them solo), while Budda Baker leads the team in sacks, with 1.5.
Detroit Lions Preview
The Detroit Lions have a 2-2 record this season are sitting on the 3rd place of the NFC North. They are coming off a 26-32 away loss against the Panthers and will face the Packers, the Vikings and the Dolphins next.
Offensively, the Lions average 29.8 points per game, ranking 5th in the NFL, while defensively, they allow 31.8 points per game, which is 31st. Detroit averages 389.3 total yards per game (287.3 passing and 102 rushing), while allowing 423.8 total yards per game (119.8 rushing and 304 passing).
Jared Goff leads the Lions with 1214 passing yards with 67.7% completed passes and nine touchdowns. Jahmyr Gibbs leads the team in rushing yards with 353, while Amon-Ra St. Brown has 31 receptions for a team-high 303 receiving yards. Defensively, Jack Campbell has a team-high 33 total tackles (17 of them solo), while Aidan Hutchinson leads the team in sacks, with 3.5.
Detroit Lions @ Arizona Cardinals Betting Trends: Week 5
Why the Arizona Cardinals will win
- The Cardinals have won eight of their last nine home games against the Lions following a loss.
- The Lions have lost seven of their last eight Week 5 road games against NFC opponents.
- The Cardinals have covered the spread in each of their last seven October games as home underdogs against NFC opponents.
- The Lions have failed to cover the spread in seven of their last eight games without Kerby Joseph.
- The Lions have lost the first half in seven of their last eight October games against NFC West opponents.
- The Lions have lost the first quarter in five of their last six games against teams that held a losing record.
- The Cardinals have scored the first touchdown in four of their last five games following a road loss.
Why the Detroit Lions will win
- The Cardinals have lost each of their last nine games against NFC opponents.
- The Lions have won each of their last six road games without Aidan Hutchinson.
- The Lions have covered the spread in 10 of their last 11 games without Jameson Williams.
- The Cardinals have failed to cover the spread in eight of their last nine home games.
- The favorites have won the first half in each of the Cardinals’ last six Week 5 games.
- The favorites have won the first quarter in each of the Cardinals’ last six Week 5 games.
- The Lions have scored the first touchdown in each of their last four Sunday games played on the West Coast.
Total Points Facts
- Each of the Lions’ last eight Sunday games as favorites have gone OVER the total points line.
- Each of the Cardinals’ last five games without Marvin Harrison Jr. have gone OVER the total points line.
- Nine of the last 11 Sunday games at State Farm Stadium have gone OVER the total points line.
Arizona Cardinals Player Prop Facts
- Trey McBride has scored at least one touchdown in each of the Cardinals’ last seven games as moderate underdogs (+3.5 to +7.0 points).
- Kendrick Bourne has recorded 25+ receiving yards in each of his last seven appearances in games with a total points line of at least 50.0.
- Jacoby Brissett has recorded 10+ rushing yards in each of his last seven October appearances with his team as an underdog.
- James Conner has recorded 81+ rushing and receiving yards in 11 of his last 12 appearances following a loss.
- Heading into Week 5, Jacoby Brissett has thrown the equal-most interceptions in a single game this season (3 vs Giants, Week 4).
Detroit Lions Player Prop Facts
- Jahmyr Gibbs has scored the last touchdown in each of the Lions’ last four games as favorites following a road loss.
- Jahmyr Gibbs has scored two or more touchdowns in four of the Lions’ last five games as moderate favorites (-3.5 to -7.0 points).
- Jared Goff has recorded 26+ completions in five of the Lions’ last six games with a total points line of at least 50.0.
- Jahmyr Gibbs has recorded 94+ rushing yards in four of the Lions’ last five games as favorites following a road loss.
- Jameson Williams has recorded 66+ receiving yards in each of the Lions’ last six Sunday road games.
- Jared Goff has recorded 327+ passing yards in each of the Lions’ last four road games with a total points line of at least 50.0.
- Jahmyr Gibbs has scored at least one touchdown in each of the Lions’ last 13 games as favorites with a total points line of at least 50.0.
- Jameson Williams has recorded 66+ rushing and receiving yards in each of the Lions’ last six Sunday road games.
- Heading into Week 5, Jahmyr Gibbs ranks T1st in the NFL in touchdowns (7) this season.
Matchup/League Facts
- Heading into Week 5, the Cardinals have allowed an average of 34.3 points over their last three games – most in the league over that span.
- Heading into Week 5, the Cardinals have allowed an average of 30.8 points over their last five games – most in the league over that span.
- Lions – five different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 5.
- Lions – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 5.
Lions vs Cardinals Prediction
In this Lions vs Cardinals Prediction, the Lions are coming as -4.5 road favorites. The Cardinals have three consecutive losses and the Lions have lost and failed to cover both of their road games this season so I prefer to take a look at the total. Both teams have been terrible defensively, ranking on the bottom—5 of the league in points allowed with 61.1 ppg combined and as a result, they are a perfect 6-0 to the over in their last six games combined. Arizona has allowed 31+ points in three straight games and the Lions have scored 31 points in three of their last four. Take the over 54.5 points in this one.