Cleveland (1-4) vs Pittsburgh (3-1)
October 12, 2025 at 01:00 PM EDT
The Line: Betting Odds: Pittsburgh -5.5 — Over/Under: +37.5
The Cleveland Browns and the Pittsburgh Steelers meet Sunday in NFL action from Acrisure Stadium. Here’s a Browns vs Steelers prediction. We will look at this from a betting perspective and determine the best Browns vs Steelers pick. We will examine:
The Cleveland Browns recent form and player performance
The Pittsburgh Steelers recent form and player performance
Recent betting trends and streaks involving the Cleveland Browns
Recent betting trends and streaks involving the Pittsburgh Steelers
Recent betting trends in games played between the Browns and Steelers
A summary that ties it all together and produces a favorable betting outcome for the Browns vs Steelers game
Cleveland Browns Betting Preview
The Browns opened up the season with a tough loss at home versus the Cincinnati Bengals 17-16, then fell in a blowout versus the Baltimore Ravens on the road 41-17. Game three was finally a win 13-10 over the Green Bay Packers, then came a 34-10 loss to the Detroit Lions. In that one Cleveland posted just 249 yards of offense, 3.8 yards per play, 16 first downs, 3-of-14 on third-down tries and three turnovers in a pretty rough overall effort.
In their Sunday morning matchup versus the Minnesota Vikings in London, Cleveland was up 17-14 going into the final quarter but ended up surrendering another score in a 21-17 loss. QB Dillon Gabriel finished 19-of-33 for 190 yards and a pair of touchdowns. Tops in rushing was Quinshon Judkins with 23 totes for 110 yards, and David Njoku had six catches for 67 yards and one touchdown in the losing effort.
Pittsburgh Steelers Betting Preview
Over on the Steelers’ side, they opened up their season with a 34-32 win over the lowly New York Jets, but then fell by two scores to the Seattle Seahawks 31-17. Pittsburgh was able to rebound the next week with a 21-14 win over the New England Patriots. In that one the Steelers gave up 369 yards total (250 passing), 5.2 yards per play and 26 first downs. The saving grace for the defense were the five takeaways (four lost fumbles). Offensively it was a pretty slow day with just 203 yards total and 17 first downs.
Matched up against the Minnesota Vikings on September 28 in their most recent outing, the Steelers held a 21-6 lead going into the final quarter. After a wild fourth that featured a 15-3 deficit, Pittsburgh was able to eke out the win 24-21 in the end. QB Aaron Rodgers finished with 200 yards and a TD on 18-of-22 passing, and Kenneth Gainwell led the rush with 19 carries for 99 yards and two scores. DK Metcalf added five receptions for 126 yards and a score of his own in the winning effort.
Cleveland Browns @ Pittsburgh Steelers Betting Trends: Week 6
Why the Pittsburgh Steelers will win
The Browns have lost each of their last 10 road games.
The Steelers have won each of their last 18 home games against the Browns following a win.
The Steelers have covered the spread in each of their last seven October games as favorites against AFC North opponents.
The Browns have failed to cover the spread in each of their last six road games against teams that held a winning record.
The favorites have won the first half in 10 of the Browns’ last 11 games.
The home team has won the first quarter in three the Steelers’ last four Week 6 games.
Why the Cleveland Browns will win
The underdogs have won six of the Steelers’ last nine Week 6 games.
The Steelers have lost each of their last three games at Acrisure Stadium.
The underdogs have covered the spread in six of the Browns’ last seven Week 6 games.
The Steelers have failed to cover the spread in each of their last three games at Acrisure Stadium.
The underdogs have won the first quarter in three of the Steelers’ last four games.
Total Points Facts
Seven of the Steelers’ last eight Week 6 games against AFC opponents have gone UNDER the total points line.
Eight of the Browns’ last 10 Sunday games as underdogs have gone UNDER the total points line.
Three of the last four games between AFC North teams have gone UNDER the total points line.
Browns vs Steelers Prediction
I’ll stick with the Steelers, but I’m probably not touching this one. Pittsburgh has to be one of the more volatile one-loss teams in the league right now, as a few of their games could easily have gone the other way. The Steelers managed 313 yards on offense in the win over Minnesota, including 182 passing yards, 5.9 yards per play, 19 first downs and a spotty 4-of-10 on third-down conversions. The defense gave up 372 yards on the other side (302 passing), 5.2 yards per play and 4-of-14 on third downs along with a couple of interceptions. Pittsburgh hasn’t given up more than 21 points in consecutive weeks, but the offense isn’t blowing anyone away right now either.
As for the Browns, they committed 10 penalties for 78 yards in their loss to the Vikings last weekend and went just 3-of-15 on third-down conversions along the way. Cleveland is in major trouble offensively this year; they’ve scored fewer than 18 points in every outing so far. The defense has been good enough to keep the Browns in a few games but I don’t think they’ll keep a tight enough lid on the rested Steelers this weekend.