| MATCHUP | Carolina Panthers | San Francisco 49ers |
|---|---|---|
| Team Records | 6-5 | 7-4 |
| Spread | +7 -105 | -7 -115 |
| Moneyline | +275 | -345 |
| Total | Over 49.5 (-108) | Under 49.5 (-112) |
| Where | Levi's Stadium, Santa Clara, CA | |
| When | Monday, November 24, 2025 | |
| Time | 08:15 PM EST | |
| TV | ESPN | |
San Francisco 49ers Preview
The San Francisco 49ers have a 7-4 record this season and are sitting third in the NFC West. They are 6-5 ATS, 7-3-1 in Over/Under and have a 3-2 home record and a 4-2 away record. The 49ers are coming off a 41-22 away win against the Arizona Cardinals and will face the Browns, Titans and Colts next.
Offensively, the 49ers average 23.7 points per game, ranking 15th in the NFL, while defensively, they allow 22.9 points per game, which is 15th. San Francisco averages 349.4 total yards per game (254.5 passing and 94.8 rushing), while allowing 352.9 total yards per game (103.8 rushing and 249.1 passing).
Mac Jones leads the 49ers with 2151 passing yards with 69.6% completed passes and 13 touchdowns. Christian McCaffrey leads the team in rushing yards with 707, while Christian McCaffrey has a team-high 74 receptions for 732 receiving yards, and five touchdowns. Defensively, Dee Winters has a team-high 77 total tackles (52 of them solo), while Bryce Huff leads the team in sacks, with 4, while Deommodore Lenoir and Malik Mustapha each have one interception.
Carolina Panthers Preview
The Carolina Panthers have a 6-5 record this season and are sitting second in the NFC South. They are 7-4 ATS, 6-5 in Over/Under and have a 3-2 home record and a 3-3 away record. The Panthers are coming off a 30-27 away win against the Atlanta Falcons and will face the Rams, Saints and Buccaneers next.
Offensively, the Panthers average 18.8 points per game, ranking 28th in the NFL, while defensively, they allow 22.6 points per game, which is 13th. Carolina averages 314.3 total yards per game (187.2 passing and 127.1 rushing), while allowing 325.9 total yards per game (113.1 rushing and 212.8 passing).
Bryce Young leads the Panthers with 1962 passing yards with 62.7% completed passes and 14 touchdowns. Rico Dowdle leads the team in rushing yards with 833, while Tetairoa McMillan has a team-high 54 receptions for 748 receiving yards, and four touchdowns. Defensively, Christian Rozeboom has a team-high 91 total tackles (43 of them solo), while Derrick Brown and Nic Scourton lead the team in sacks, with 3 each.
Carolina Panthers @ San Francisco 49ers Betting Trends: Week 12
Why the San Francisco 49ers will win
- The Panthers have lost each of their last 11 games following a road win.
- The 49ers have won each of their last five home games against NFC South opponents.
- The Panthers have failed to cover the spread in each of their last 11 games following a road win.
- The favorites have covered the spread in seven of the 49ers’ last eight Week 12 games.
- The 49ers have won the first half in each of their last nine November games as favorites.
- The 49ers have won the first quarter in each of their last nine Monday games against teams that held a winning record.
- The 49ers have scored the first touchdown in each of their last seven home games against NFC South opponents.
Why the Carolina Panthers will win
- The Panthers have won each of their last four games as underdogs against NFC opponents.
- The 49ers have lost five of their last six games as home favorites following a win.
- The 49ers have failed to cover the spread in each of their last 12 home games following a win.
- The Panthers have covered the spread in each of their last six games as underdogs against NFC opponents.
- The 49ers have lost the first quarter in three of their last four Monday games as favorites.
- The Panthers have scored the first touchdown in each of their last four road games.
- The 49ers have lost the first half in each of their last four games following a win.
Total Points Facts
- Each of the 49ers’ last five November games against NFC South opponents have gone UNDER the total points line.
- Each of the Panthers’ last four games against NFC West opponents have gone OVER the total points line.
- Each of the last three Monday games at Levi’s Stadium have gone OVER the total points line.
San Francisco 49ers Player Prop Facts
- Christian McCaffrey has scored two or more touchdowns in three of the 49ers’ last four games against NFC opponents.
- George Kittle has recorded 61+ receiving yards in each of his last seven regular season appearances with the 49ers as home favorites against NFC opponents.
- Christian McCaffrey has scored at least one touchdown in 10 of his 11 appearances with the 49ers as home favorites against teams that held a winning record.
- Mac Jones has recorded 279+ passing yards in each of the 49ers’ last four games following a road win.
- Brock Purdy has recorded 11+ rushing yards in 12 of his last 13 appearances in California.
- Christian McCaffrey has recorded 121+ rushing and receiving yards in each of the 49ers’ last four games as favorites.
- Mac Jones has recorded 26+ completions in each of the 49ers’ last four games following a road win.
- Heading into Week 12, Christian McCaffrey is the only player in the NFL to record 5+ rushing and 5+ receiving TDs this season.
Carolina Panthers Player Prop Facts
- Chuba Hubbard has scored a touchdown in four of his last five appearances against teams that held a winning record.
- Andy Dalton has recorded 260+ passing yards in three of his last four appearances against NFC West opponents.
- Xavier Legette has recorded 22+ receiving yards in each of the Panthers’ last five November games as underdogs.
- Chuba Hubbard has recorded 17+ rushing yards in each of his last 21 appearances with the Panthers as underdogs.
- Chuba Hubbard has recorded 34+ rushing and receiving yards in each of his last 12 appearances with the Panthers as underdogs following a win.
- Bryce Young has recorded 18+ completions in each of the Panthers’ last four road games as moderate underdogs (+3.5 to +7.0 points).
- Heading into Week 12, Jaycee Horn has recorded the equal-most interceptions in a single game this season (2 vs Jets, Week 7).
Matchup/League Facts
- Heading into Week 12, the 49ers rank 32nd in the NFL in sacks (12.0) this season.
- Heading into Week 12, the 49ers rank 1st in the NFL in 1st downs (240) this season.
- Heading into Week 12, the Panthers rank 1st in the NFL in 4th down attempts (27) this season.
- Heading into Week 12, the Panthers are the only team to overturn multiple 10+ point 2nd quarter deficits to win this season.
Panthers vs 49ers Prediction
In this Panthers vs 49ers Prediction, the 49ers are coming as -7-point road favorites. The 49ers have just one win more than the Panthers and both teams have been totally balanced in their home/away splits with a 2-2 and 3-3 record. They have also been up and down in their recent games so don’t like either side in this matchup. Both teams have been below average offensively, scoring just 42.5 points per game combined, while allowing 45.5 points per game combined defensively. Both numbers are way lower than today’s total set at 48.5 points, so like the under in this one.