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Buffalo Bills vs Denver Broncos Prediction 1/17/2026 Today’s NFL Picks

Jan 4, 2026; Denver, Colorado, USA; Denver Broncos tight end Evan Engram (1) looks on after winning the game against the Los Angeles Chargers at Empower Field at Mile High. Mandatory Credit: Ron Chenoy-Imagn Images

Jan 4, 2026; Denver, Colorado, USA; Denver Broncos tight end Evan Engram (1) looks on after winning the game against the Los Angeles Chargers at Empower Field at Mile High. Mandatory Credit: Ron Chenoy-Imagn Images

MATCHUP Buffalo Bills Denver Broncos
Team Records 12-5 14-3
Spread +1.5 -112 -1.5 -108
Moneyline +100 -120
Total Over 45.5 (-112) Under 45.5 (-108)
When Saturday, January 17, 2026
Time 04:30 PM EST
TV CBS
The Buffalo Bills and Denver Broncos meet Saturday in the AFC Divisional Playoffs at Empower Field. Here’s a Buffalo Bills vs Denver Broncos Prediction. This article will include a Buffalo Bills vs Denver Broncos Pick.

Buffalo Bills Betting Preview


The Buffalo Bills beat the Jets and Jaguars. The Bills have won 6 of their last 7 games. The Bills look to make the conference championship for a second straight season. Josh Allen is completing 69.3 percent of his passes for 3,668 yards, 25 touchdowns, and 10 interceptions. Khalil Shakir and Dalton Kincaid have combined for 1,290 receiving yards and 9 touchdowns, while Dawson Knox has 36 receptions.

The Buffalo Bills ground game is averaging 159.6 yards per contest, and James Cook leads the way with 1,621 yards and 12 touchdowns. Defensively, Buffalo is allowing 21.5 points and 293.1 yards per game. Cole Bishop leads the Buffalo Bills with 85 tackles, Greg Rousseau has 7 sacks and Maxwell Hairston has 2 interceptions.

Denver Broncos Betting Preview


The Denver Broncos beat the Chiefs and Chargers. The Broncos have won 13 of their last 14 games. The Broncos look to make their first conference championship since the 2015 season. Bo Nix is completing 63.4 percent of his passes for 3,931 yards, 25 touchdowns, and 11 interceptions. Troy Franklin and Courtland Sutton have combined for 1,726 receiving yards and 13 touchdowns, while Evan Engram has 50 receptions.

The Denver Broncos ground game is averaging 118.7 yards per contest, and J.K. Dobbins leads the way with 772 yards and 4 touchdowns. Defensively, Denver is allowing 18.3 points and 278.2 yards per game. Alex Singleton leads the Denver Broncos with 135 tackles, Nik Bonitto has 14 sacks and Dondrea Tillman has 2 interceptions.

Why the Denver Broncos will win

Why the Buffalo Bills will win

Total Points Facts

Denver Broncos Player Prop Facts

Buffalo Bills Player Prop Facts

Matchup/League Facts

Buffalo Bills vs Denver Broncos Prediction


You can talk yourself into the Bills as an underdog, as they may not be the better team, but none of that matters when Josh Allen is the quarterback. Since December 2024, the Bills are 5-1 SU and ATS as an underdog. I’m still going to lean toward the Broncos in this pick em spot. Home field, rest advantage, and an elite defense that just finds a way. The Broncos’ offense is also underrated, as it finished 10th in total offense and 14th in scoring.

Nix takes care of the ball and there are some playmakers on the outside. The Broncos also just have a confidence about them that they’ll find a way, losing just one game since week 4. This has the potential to get sweaty late in the fourth quarter. I’ll still ride with the defense of the Broncos to will its way to victory.

Randy Chambers's Pick: Denver Broncos -1.5

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