| MATCHUP | Denver Broncos | Arizona Cardinals |
|---|---|---|
| Team Records | 4-2 | 2-4 |
| Spread | -4.5 -110 | +4.5 -110 |
| Moneyline | -230 | +190 |
| Total | Over 43.5 (-112) | Under 43.5 (-108) |
| Where | State Farm Stadium, Glendale, AZ | |
| When | Sunday, October 25, 2026 | |
| Time | 04:05 PM EDT | |
| TV | CBS | |
In this article we will formulate a Broncos vs Cardinals prediction for this NFL game on Sunday, October 25th at State Farm Stadium in Glendale, Arizona. Let’s take a look at the prediction for this week 7 matchup.
Denver Broncos Betting Preview
The Denver Broncos are 4-2 this year after they defeated the Seahawks in overtime by a score of 17-14 last week. Denver led 14-3 at halftime, but they went scoreless in the second half, before escaping with the win in OT. The Broncos were out gained by a total of 353-168, went 3-14 on third downs, and won the turnover battle by a total of 3-0 in the game. Bo Nix threw for 107 yards, while RJ Harvey caught three passes for 31 yards. JK Dobbins rushed 17 times for 41 yards and one score in the win.
Prior to that game, Denver defeated the Chargers by a score of 23-17, but lost to the 49ers by a score of 24-14 before that. The Broncos have scored 19.0 points per game with 168.0 passing yards and 84.2 rushing yards per game, while they have allowed 20.8 points against per game this season. Bo Nix has thrown for 1,049 yards with six touchdowns and three interceptions, while Jaylen Waddle has 22 receptions for 228 yards and one score this year.
Arizona Cardinals Betting Preview
The Arizona Cardinals are 2-4 this season after they defeated the Rams by a score of 18-16 in their last game. Arizona was tied 9-9 at halftime, but they blew a 15-9 lead in the fourth, before kicking a field goal as time expired for the win. The Cardinals out gained LA by a total of 338-286, went 5-15 on third downs, and tied the turnover battle at one in the game. Jacoby Brissett threw for 218 yards and one interception, while Trey McBride caught seven passes for 53 yards. Bam Knight rushed 15 times for 80 yards in the game.
Prior to that win, Arizona lost to the Lions by a score of 45-21 and the Giants by a score of 36-24. The Cardinals have scored 21.0 points per game with 211.0 passing yards and 96.3 rushing yards per game, while they have allowed 29.7 points against per game this season. Jacoby Brissett has thrown for 1,328 yards with nine touchdowns and six interceptions, while Trey McBride has 49 receptions for 361 yards and three scores this season.
Why the Arizona Cardinals will win
- The Broncos have lost six of their last seven games as road favorites when playing with a rest advantage.
- The home team has won five of the Broncos’ last six games.
- The home team has covered the spread in nine of the Broncos’ last 10 games.
- The Broncos have failed to cover the spread in nine of their last 10 games as road favorites before a Division game.
- The Broncos have lost the first half in each of their last three games as road favorites against NFC West opponents.
- The Cardinals have won the first quarter in each of their last three home games in October.
Why the Denver Broncos will win
- The Cardinals have lost each of their last 14 day games against opponents on a winning streak.
- The Broncos have won each of their last nine Sunday games against teams that held a losing record.
- The Cardinals have failed to cover the spread in each of their last six home games.
- The favorites have covered the spread in seven of the Broncos’ last eight Week 7 games.
- The Cardinals have lost the first half in six of their last seven games against teams that held a winning record.
- The Cardinals have lost the first quarter in seven of their last nine day games following a road win.
Total Points Facts
- Nine of the Broncos’ last 10 games as favorites following a home win have gone OVER the total points line.
- Six of the Cardinals’ last seven games in October have gone OVER the total points line.
- Ten of the last 12 Sunday day games at State Farm Stadium have gone OVER the total points line.
Arizona Cardinals Player Prop Facts
- Trey McBride has scored at least one touchdown in each of the Cardinals’ last seven day games as moderate underdogs (+3.5 to +7.0 points).
- Jacoby Brissett has recorded 24+ completions in four of the Cardinals’ last five games as underdogs.
- Jacoby Brissett has recorded 249+ passing yards in four of the Cardinals’ last five games as underdogs against AFC opponents.
- Jacoby Brissett has recorded 10+ rushing yards in eight of his last nine October appearances with his team as an underdog.
- James Conner has recorded 20+ receiving yards in each of his last six appearances with his team as an underdog against AFC West opponents.
- James Conner has recorded 113+ rushing and receiving yards in six of his last seven appearances at State Farm Stadium.
- Heading into Week 7, Jacoby Brissett has thrown the equal-most interceptions in a single game this season (3 vs Giants, Week 4).
Denver Broncos Player Prop Facts
- RJ Harvey has scored at least one touchdown in each of the Broncos’ last three games as favorites against NFC opponents.
- Bo Nix has recorded 247+ passing yards in each of the Broncos’ last four games as favorites following a home win.
- RJ Harvey has recorded 20+ rushing yards in eight of his last nine appearances in day games.
- Evan Engram has recorded 36+ receiving yards in each of his last eight appearances with his team as a favorite against NFC opponents.
- Marvin Mims Jr. has recorded 17+ rushing and receiving yards in each of the Broncos’ last eight games as favorites following a home win.
- Jarrett Stidham has recorded 17+ completions in each of his five previous appearances as a starter.
- Heading into Week 7, Alex Singleton leads the league for tackles (68) this season.
Matchup/League Facts
- Cardinals – three different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 7.
- Cardinals – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 7.
- Heading into Week 7, the Broncos have overturned the largest 2nd quarter deficit to win a game this season – 16 points vs LA Rams.
- Heading into Week 7, the Broncos have given up the largest 2nd quarter lead to win a game this season – 16 points vs LA Rams.
Broncos vs Cardinals Prediction
Arizona comes into this contest after an upset win over the Rams last week, but they failed to score a touchdown in that game. The Cardinals are 0-2 at home this year, while the Broncos are 1-2 on the road. Denver has won four of their last five games and they have allowed 17 or fewer in three of their last five. The Broncos have a very average offensive attack, but they keep finding ways to win. Take Denver to cover on the road here, as I don’t trust the Arizona defense.