| MATCHUP | Denver Broncos | San Francisco 49ers |
|---|---|---|
| Team Records | 2-1 | 3-0 |
| Spread | +3 -120 | -3 100 |
| Moneyline | +124 | -148 |
| Total | Over 47.5 (-110) | Under 47.5 (-110) |
| Where | Levi's Stadium, Santa Clara, CA | |
| When | Sunday, October 4, 2026 | |
| Time | 04:25 PM EDT | |
| TV | CBS | |
Denver Broncos Betting Preview
The Denver Broncos are 2-1 this year after they defeated the Rams by a score of 30-26 last week. Denver trailed 16-0 at halftime and 26-23 late in the fourth, but they scored with 47 seconds left to escape with the win. The Broncos were out gained by a total of 482-257, went 7-13 on third downs, and won the turnover battle by a total of 2-1 in the game. Bo Nix threw for 186 yards, two touchdowns, and one interception, while Courtland Sutton caught three passes for 46 yards. JK Dobbins rushed 17 times for 49 yards in the loss.Prior to that game, Denver defeated the Jaguars by a score of 20-13, but lost to the Chiefs by a score of 31-10 before that. The Broncos have scored 20.0 points per game with 194.0 passing yards and 81.0 rushing yards per game, while they have allowed 23.3 points against per game this season. Bo Nix has thrown for 605 yards with four touchdowns and three interceptions, while Jaylen Waddle has 11 receptions for 150 yards this year.
San Francisco 49ers Betting Preview
The San Francisco 49ers are 3-0 this season after they defeated the Cardinals by a score of 36-30 in their last game. San Francisco led 17-6 at halftime and 23-6 in the third, but they allowed 24 points in the second half to blow the cover. The 49ers out gained Arizona by a total of 437-365, went 5-8 on third downs, and lost the turnover battle by a total of 1-0 in the game. Brock Purdy threw for 297 yards and four touchdowns, while George Kittle had six catches for 82 yards and two scores. Christian McCaffrey rushed 15 times for 75 yards and one touchdown in the win.Prior to that game, San Francisco defeated the Dolphins by a score of 35-13 and the Rams by a score of 27-7. The 49ers have scored 32.7 points per game with 263.0 passing yards and 136.3 rushing yards per game, while they have allowed 16.7 points against per game this season. Brock Purdy has thrown for 789 yards with nine touchdowns and one interception, while George Kittle has 12 receptions for 174 yards and three scores this season.
Why the San Francisco 49ers will win
- The 49ers have won each of their last nine games as favorites.
- The Broncos have lost six of their last seven games in California.
- The home team has covered the spread in 11 of the Broncos’ last 12 games.
- The Broncos have failed to cover the spread in each of their last four road games without Jarrett Stidham.
- The Broncos have lost the first half in each of their last six games as slight underdogs (<+3.5 points).
- The Broncos have lost the first quarter in three of their last four games following a home win.
Why the Denver Broncos will win
- The Broncos have won each of their last nine October games against NFC opponents.
- The 49ers have lost each of their last five October games as home favorites against AFC opponents.
- The 49ers have failed to cover the spread in each of their last seven games against AFC West opponents.
- The Broncos have covered the spread in eight of their last nine games against teams that held a winning record.
- The Broncos have won the first half in three of their last four games as underdogs in California.
Total Points Facts
- Eight of the 49ers’ last nine home games against AFC opponents have gone OVER the total points line.
- Each of the Broncos’ last five games as road underdogs have gone UNDER the total points line.
San Francisco 49ers Player Prop Facts
- George Kittle has scored at least one touchdown in each of his last four appearances with the 49ers as favorites.
- Brock Purdy has recorded 19+ rushing yards in each of his last six October appearances.
- Brock Purdy has recorded 287+ passing yards in each of his last six Sunday appearances at Levi’s Stadium.
- George Kittle has recorded 64+ receiving yards in each of his last seven Sunday appearances with the 49ers as home favorites.
- Deebo Samuel has recorded 51+ rushing and receiving yards in 15 of his last 19 regular season appearances with the 49ers as favorites against AFC opponents.
- Heading into Week 4, Brock Purdy ranks 1st amongst qualified players for passer rating (133.1) this season.
Denver Broncos Player Prop Facts
- Courtland Sutton has scored a touchdown in six of the Broncos’ last seven games as underdogs against teams on a winning streak.
- Bo Nix has recorded 242+ passing yards in each of the Broncos’ last four October games against NFC opponents.
- RJ Harvey has recorded 47+ rushing and receiving yards in nine of his last 10 Sunday appearances.
- RJ Harvey has recorded 18+ rushing yards in eight of his last nine regular season appearances.
- Troy Franklin has recorded 19+ receiving yards in each of his last nine appearances with the Broncos as underdogs following a win.
- Jarrett Stidham has recorded two or more completions in eight of his 10 previous appearances with his team as an underdog.
- Heading into Week 4, Riley Moss ranks T1st in the AFC for passes defensed (5) this season.
Matchup/League Facts
- Heading into Week 4, the 49ers rank 1st in the NFL in Q3 points per game (11.3) this season.
- Heading into Week 4, the 49ers rank 1st in the NFL in Q1 win percentage (100.0) this season.
- Heading into Week 4, the Broncos rank 32nd in the NFL in H1 points per game (3.3) this season.
- Heading into Week 4, the Broncos rank 32nd in the NFL in average point differential in second quarters this season (-7.7).