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Atlanta Falcons vs. Indianapolis Colts Prediction 8/22/2026 Today’s NFL Picks

Indianapolis Colts quarterback Anthony Richardson Sr. (5) drops back to pass Wednesday, Aug. 19, 2026, during a joint practice with the Atlanta Falcons at Grand Park in Westfield.

Indianapolis Colts quarterback Anthony Richardson Sr. (5) drops back to pass Wednesday, Aug. 19, 2026, during a joint practice with the Atlanta Falcons at Grand Park in Westfield.

Atlanta Falcons vs. Indianapolis Colts

01:00 PM EDT

The Line: Betting Odds: Indianapolis Colts -3.5 — Over/Under: 36

(Get latest betting odds)

The Atlanta Falcons and the Indianapolis Colts meet in week 2 NFL preseason action from Lucas Oil Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Atlanta Falcons vs. Indianapolis Colts Prediction.

Atlanta Falcons Recap

The Atlanta Falcons come into this game looking to rebound from a 27-7 loss at the hands of the Falcons in their preseason opener to fall to 0-1. After this game, the Falcons will close out the preseason with a game against the Miami Dolphins on the road.

Falcons Looking To Rebound From Dud In Opener

Cooper Rush threw for 62 yards and 2 INTs on 7 of 19 passing while Jack Strand threw for 50 yards on 6 of 12 passing and Tua Tagovailoa went 3 of 5 for 22 yards, Strand called his own number for a rushing TD for the Falcons’ lone touchdown in the loss while Tyler Goodson rushed for 28 yards on 7 carries. Chris Blair added 37 receiving yards while Joshua Simon added a pair of catches for 29 yards and Kyle Pitts Sr. had a team-high 3 catches for 22 yards. On defense, Josh Woods and Sydney Brown each had a team-high 6 total tackles with Woods logging 4 solo tackles and a TFL. Azeez Ojulari and Kendal Daniels combined for a sack while Josh Woods, A.J. Woods and Ojulari all had a TFL in the losing effort.

Indianapolis Colts Recap

The Indianapolis Colts come into this game looking to shake off a 13-13 tie against the New England Patriots in their preseason opener. After this game, the Colts will take on the Detroit Lions in their preseason finale.

Colts Looking To Get Job Done In Second Preseason Affair

Anthony Richardson Sr. threw for 145 yards and an interception on 11 of 14 passing while Riley Leonard threw for 89 yards and a pick on 10 of 21 passing. Richardson Sr. led the Colts in rushing with 6 carries for 53 yards and a TD while Anderson Castle added 9 carries for 47 yards of his own. Will Mallory led Indy’s receiving group with 6 catches for 80 yards while Raylen Sharpe added 4 catches for 29 yards. On defense, Caden Curry led the way with 6 total tackles including a sack and 2 TFLs while George Gumbs Jr. added a sack as well in the tie.

Atlanta Falcons vs. Indianapolis Colts Prediction

I’m on the Colts in this one. I just have zero faith in the Falcons right now because of their quarterback situation and the Colts in their preseason opener were a prime example of how big of a role motivation and position battles play in the preseason. I think Indianapolis gets it done here so give me the Colts.

Chris Ruffolo's Pick: Indianapolis -3.5

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