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Arizona Cardinals vs Cincinnati Bengals Prediction 12/28/2025 Today’s NFL Picks

Dec 21, 2025; Miami Gardens, Florida, USA; Cincinnati Bengals wide receiver Tee Higgins (5) scores a touchdown during the second quarter against the Miami Dolphins at Hard Rock Stadium. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

Dec 21, 2025; Miami Gardens, Florida, USA; Cincinnati Bengals wide receiver Tee Higgins (5) scores a touchdown during the second quarter against the Miami Dolphins at Hard Rock Stadium. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

MATCHUP Arizona Cardinals Cincinnati Bengals
Team Records 3-12 5-10
Spread +7.5 -115 -7.5 -105
Moneyline +300 -380
Total Over 53.5 (-105) Under 53.5 (-115)
Where Paycor Stadium, Cincinnati, OH
When Sunday, December 28, 2025
Time 01:00 PM EST
TV FOX
The Arizona Cardinals and Cincinnati Bengals meet Sunday in NFL action at Paycor Stadium. Here’s a Arizona Cardinals vs Cincinnati Bengals Prediction. This article will include a Arizona Cardinals vs Cincinnati Bengals Pick.

Arizona Cardinals Betting Preview


The Arizona Cardinals lost to the Falcons and Texans, and play the Rams next. The Arizona Cardinals have lost 7 straight games. Jacoby Brissett is completing 65.2 percent of his passes for 2,911 yards, 19 touchdowns, and 7 interceptions. Trey McBride and Michael Wilson have combined for 1,916 receiving yards and 15 touchdowns, while Marvin Harrison Jr. has 41 receptions.

The Arizona Cardinals ground game is averaging 97.5 yards per contest, and Michael Carter leads the way with 286 yards and 1 touchdown. Defensively, Arizona is allowing 27.6 points and 350.5 yards per game. Budda Baker leads the Arizona Cardinals with 111 tackles, Josh Sweat has 11 sacks and Denzel Burke has 3 interceptions.

Cincinnati Bengals Betting Preview


The Cincinnati Bengals lost to the Ravens, beat the Dolphins, and they play the Browns next. The Cincinnati Bengals have lost 6 of their last 8 games. Joe Burrow is completing 63.5 percent of his passes for 1,268 yards, 12 touchdowns, and 4 interceptions. Ja’Marr Chase and Tee Higgins have combined for 1,976 receiving yards and 15 touchdowns, while Andrei Iosivas has 27 receptions.

The Cincinnati Bengals ground game is averaging 88.6 yards per contest, and Chase Brown leads the way with 846 yards and 4 touchdowns. Defensively, Cincinnati is allowing 30.5 points and 402.8 yards per game. Jordan Battle leads the Cincinnati Bengals with 119 tackles, Joseph Ossai has 5 sacks and Demetrius Knight Jr. has 2 interceptions.

Why the Cincinnati Bengals will win

Why the Arizona Cardinals will win

Total Points Facts

Cincinnati Bengals Player Prop Facts

Arizona Cardinals Player Prop Facts

Matchup/League Facts

Arizona Cardinals vs Cincinnati Bengals Prediction


The Cardinals are a bad team on both sides and are dealing with endless injuries as they’re just waiting for the season to end. However, that doesn’t mean we lay more than a touchdown with the Bengals. While talented on the offensive side, the Bengals’ defense is arguably the worst in the league. The Bengals are 31st in total defense and 32nd in scoring defense. This will be the first time in over a year since the Bengals are favorites of 6 or more points. I’m just not doing it. There are better games out there but if forced to pick I’m grabbing the points. I typically don’t lay huge numbers with teams that don’t play a lick of defense. The hook could be key as well.

Randy Chambers's Pick: Arizona Cardinals +7.5

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