San Francisco (5-2) vs Houston (2-4)
October 26, 2025 at 01:00 PM EDT
The Line: Betting Odds: Houston -1.5 — Over/Under: +41.5
In this article we will formulate a 49ers vs Texans prediction for this NFL game on Sunday, October 26th at NRG Stadium in Houston, Texas. Let’s take a look at the prediction for this week 8 matchup.
Prior to that win, San Francisco lost to Tampa Bay by a score of 30-19, but did beat the Rams by a score of 26-23 before that. The 49ers have alternated wins and losses over their last five games and they are currently tied for first in the NFC West standings. San Francisco has scored 20.7 points per game with 271.3 passing yards and 95.3 rushing yards per game, while they have allowed 19.7 points against per game this season. Mac Jones has thrown for 1,404 yards, six touchdowns, and four interceptions, while Christian McCaffrey has 465 rushing yards and 516 receiving yards, with a total of six touchdowns this year.
Prior to that loss, Houston defeated the Ravens by a score of 44-10 and the Titans by a score of 26-0. The Texans have won two of their last three games and they are currently third in the AFC South standings. Houston has scored 21.2 points per game with 198.2 passing yards and 106.2 rushing yards per game, while they have allowed 14.7 points against per game this season. CJ Stroud has thrown for 1,305 yards, nine touchdowns, and four interceptions, while Nico Collins has 26 receptions for 339 yards and three scores this season.
The Texans have won each of their last four October games at NRG Stadium.
The 49ers have failed to cover the spread in each of their last five Sunday games as road underdogs.
The favorites have covered the spread in five of the Texans’ last six games.
The 49ers have lost the first half in each of their last five Week 8 games.
Each of the 49ers’ last four road games against AFC South opponents have gone UNDER the total points line.
C.J. Stroud has recorded 22+ completions in each of the Texans’ last four games.
Christian Kirk has recorded 39+ receiving yards in each of his last 14 regular season appearances against NFC opponents.
Nick Chubb has recorded 41+ rushing yards in each of his last 23 appearances with his team as a favorite following a loss.
Nico Collins has scored the first touchdown in three of the Texans’ last four games as home favorites against NFC opponents.
Nick Chubb has recorded 60+ rushing and receiving yards in each of his last 26 appearances with his team as a home favorite.
Nico Collins has scored a touchdown in eight of his last nine appearances at NRG Stadium against teams that held a winning record.
Heading into Week 8, Ka’imi Fairbairn ranks T2nd in the NFL in 50+ yard field goals made (5) this season.
Brian Robinson has recorded 35+ rushing and receiving yards in 15 of his last 16 Sunday regular season appearances with his team as an underdog.
Russell Gage has scored the last touchdown in three of his last four Sunday appearances with his team as an underdog.
Brock Purdy has recorded 277+ passing yards in each of his last four Sunday appearances.
Christian McCaffrey has recorded 52+ receiving yards in each of the 49ers’ last six Sunday games.
Brian Robinson has recorded 13+ rushing yards in 40 of his 42 previous Sunday appearances.
Brock Purdy has recorded 22+ completions in six of his last seven Sunday regular season road appearances.
Heading into Week 8, Christian McCaffrey ranks 1st in the NFL in rushing attempts (132) this season.
Heading into Week 8, the Texans rank 1st in the NFL in Q2 opponent points per game (2.3) this season.
Heading into Week 8, the 49ers rank T1st in the NFL in fumbles recovered (6) this season.
49ers – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 8.
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San Francisco 49ers Betting Preview
The San Francisco 49ers are 5-2 this year after they defeated Atlanta by a score of 20-10 last week. San Francisco led 10-3 at halftime and put the game away with the only points of the fourth quarter. The 49ers out gained Atlanta by a total of 324-292, went 9-15 on third downs, and tied the turnover battle at one in the game. Mac Jones went 17-26 for 152 yards and one interception, while Christian McCaffrey rushed 24 times for 129 yards and two scores. McCaffrey also led the receivers with seven catches for 72 yards in the win. The SF defense recorded two sacks and four tackles for loss in the game.Prior to that win, San Francisco lost to Tampa Bay by a score of 30-19, but did beat the Rams by a score of 26-23 before that. The 49ers have alternated wins and losses over their last five games and they are currently tied for first in the NFC West standings. San Francisco has scored 20.7 points per game with 271.3 passing yards and 95.3 rushing yards per game, while they have allowed 19.7 points against per game this season. Mac Jones has thrown for 1,404 yards, six touchdowns, and four interceptions, while Christian McCaffrey has 465 rushing yards and 516 receiving yards, with a total of six touchdowns this year.
Houston Texans Betting Preview
The Houston Texans are 2-4 this season after they lost to Seattle by a score of 27-19 in their last game. Houston trailed 14-6 at halftime, but they had several chances to get back into the game in the second half, before falling short. The Texans were out gained by a total of 316-254, went 2-15 on third downs, and won the turnover battle by a total of 4-1 in the game. CJ Stroud went 23-49 for 229 yards, one touchdown, and one interception, while also rushing for 25 yards on two carries. Dalton Schultz led the receivers with nine catches for 98 yards in the loss. The Houston defense recorded two sacks and seven tackles for loss in the game.Prior to that loss, Houston defeated the Ravens by a score of 44-10 and the Titans by a score of 26-0. The Texans have won two of their last three games and they are currently third in the AFC South standings. Houston has scored 21.2 points per game with 198.2 passing yards and 106.2 rushing yards per game, while they have allowed 14.7 points against per game this season. CJ Stroud has thrown for 1,305 yards, nine touchdowns, and four interceptions, while Nico Collins has 26 receptions for 339 yards and three scores this season.
Why the Houston Texans will win
The 49ers have lost each of their last four games against AFC opponents.The Texans have won each of their last four October games at NRG Stadium.
The 49ers have failed to cover the spread in each of their last five Sunday games as road underdogs.
The favorites have covered the spread in five of the Texans’ last six games.
The 49ers have lost the first half in each of their last five Week 8 games.
Total Points Facts
Ten of the Texans’ last 11 games as home favorites have gone UNDER the total points line.Each of the 49ers’ last four road games against AFC South opponents have gone UNDER the total points line.
Houston Texans Player Prop Facts
C.J. Stroud has recorded 232+ passing yards in seven of the Texans’ last eight Sunday games at NRG Stadium.C.J. Stroud has recorded 22+ completions in each of the Texans’ last four games.
Christian Kirk has recorded 39+ receiving yards in each of his last 14 regular season appearances against NFC opponents.
Nick Chubb has recorded 41+ rushing yards in each of his last 23 appearances with his team as a favorite following a loss.
Nico Collins has scored the first touchdown in three of the Texans’ last four games as home favorites against NFC opponents.
Nick Chubb has recorded 60+ rushing and receiving yards in each of his last 26 appearances with his team as a home favorite.
Nico Collins has scored a touchdown in eight of his last nine appearances at NRG Stadium against teams that held a winning record.
Heading into Week 8, Ka’imi Fairbairn ranks T2nd in the NFL in 50+ yard field goals made (5) this season.
San Francisco 49ers Player Prop Facts
Christian McCaffrey has scored at least one touchdown in nine of his last 10 appearances with his team as an underdog following a win.Brian Robinson has recorded 35+ rushing and receiving yards in 15 of his last 16 Sunday regular season appearances with his team as an underdog.
Russell Gage has scored the last touchdown in three of his last four Sunday appearances with his team as an underdog.
Brock Purdy has recorded 277+ passing yards in each of his last four Sunday appearances.
Christian McCaffrey has recorded 52+ receiving yards in each of the 49ers’ last six Sunday games.
Brian Robinson has recorded 13+ rushing yards in 40 of his 42 previous Sunday appearances.
Brock Purdy has recorded 22+ completions in six of his last seven Sunday regular season road appearances.
Heading into Week 8, Christian McCaffrey ranks 1st in the NFL in rushing attempts (132) this season.
Matchup/League Facts
Heading into Week 8, the Texans have recorded the largest margin of victory in a road game this season (34-points vs Baltimore on October 5, 2025).Heading into Week 8, the Texans rank 1st in the NFL in Q2 opponent points per game (2.3) this season.
Heading into Week 8, the 49ers rank T1st in the NFL in fumbles recovered (6) this season.
49ers – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 8.
49ers vs Texans Prediction
Houston comes into this matchup after winning two of their last three games, but both wins came against struggling teams and their offense was bad once again last week. The Texans have had offensive issues all season, as Stroud struggles to be consistent, but their defense has been pretty good. San Francisco has battled a bunch of injuries so far this year and it sounds like they will be without Purdy once again here. The 49ers have picked up some decent wins, but you never know how Mac Jones is going to play. I don’t love backing the Houston offense right now, but I will take the Texans and their defense at home.David Racey is 43-26 (63%) in the NFL this season and he is currently #1 on the NFL Leaderboard. Click here for his premium plays for this week!