Arizona Cardinals at San Francisco 49ers - 1/8/23 NFL Picks and Prediction

San Francisco 49ers (12-4) vs Arizona Cardinals (4-12)

Game Info: Sunday, January 8, 2023 at 4:25 pm (Levi's Stadium)

Betting Odds: San Francisco 49ers -14 -- Over/Under: 39.5 Click Here for the Latest Odds

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The Arizona Cardinals and San Francisco 49ers meet Sunday in week 18 NFL action at Levi's Stadium. The Arizona Cardinals have lost 6 straight games. The San Francisco 49ers have won 9 straight games.

The Arizona Cardinals have lost 4 of their last 6 road games. Colt McCoy is completing 68.2 percent of his passes for 780 yards, 1 touchdown and 3 interceptions. DeAndre Hopkins and Marquise Brown have combined for 1,419 receiving yards and 6 touchdowns, while Greg Dortch has 48 receptions. The Arizona Cardinals ground game is averaging 113.3 yards per contest, and James Conner leads the way with 782 yards and 7 touchdowns. Defensively, Arizona is allowing 25.7 points and 351.3 yards per game. Budda Baker leads the Arizona Cardinals with 111 tackles, J.J. Watt has 10.5 sacks and Marco Wilson has 3 interceptions.

The San Francisco 49ers have won 5 straight home games. Brock Purdy is completing 66 percent of his passes for 1,196 yards, 10 touchdowns and 4 interceptions. Brandon Aiyuk and George Kittle have combined for 1,692 receiving yards and 17 touchdowns, while Deebo Samuel has 54 receptions. The San Francisco 49ers ground game is averaging 136.9 yards per contest, and Christian McCaffrey leads the way with 701 yards and 6 touchdowns. Defensively, San Francisco is allowing 16.5 points and 303.4 yards per game. Dre Greenlaw leads the San Francisco 49ers with 127 tackles, Nick Bosa has 17.5 sacks and Talanoa Hufanga has 4 interceptions.

The Cardinals are 12-5 ATS in their last 17 road games and 3-7 ATS in their last 10 games in January. The 49ers are 4-0 ATS in their last 4 home games and 20-8 ATS in their last 28 games overall. The over is 7-3 in Cardinals last 10 games overall. The over is 4-1 in 49ers last 5 games overall. The Cardinals are 5-0-1 ATS in their last 6 meetings in San Francisco and 7-2-1 ATS in their last 10 meetings. The underdog is 6-2-1 ATS in their last 9 meetings. The road team is 4-1-1 ATS in their last 6 meetings.

This is a massive line, and I'm not excited about laying two touchdowns, but the Arizona Cardinals are a complete mess right now, and they have nothing to play for at this point. The San Francisco 49ers have been covering machines dating back to last season, and they're head and shoulders the better team on both sides of the ball. Again, the line is thick, but it would shock nobody to see the 49ers run away with this one. It's laying the points or pass for me.

Randy’s Pick San Francisco 49ers -14

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

Mitch's Take...

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