San Francisco 49ers at Arizona Cardinals - 11/21/22 NFL Picks and Prediction

Arizona Cardinals (4-6) vs San Francisco 49ers (5-4)

Game Info: Monday, November 21, 2022 at 8:15 pm (Estadio Azteca)

Betting Odds: Arizona Cardinals +8.5 -- Over/Under: 43.5 Click Here for the Latest Odds

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The San Francisco 49ers will play the Arizona Cardinals on Monday Night Football in NFL action at Estadio Azteca in Mexico City.

The San Francisco 49ers are 5-4 this season after they defeated the Los Angeles Chargers by a score of 22-16 in their last game. San Francisco out gained Los Angeles by a total of 387-238 and went 9-17 on third down attempts in the win. The San Francisco offense is averaging 22 points per game with 236.3 passing yards per game and 123.7 rushing yards per game. Jimmy Garoppolo has thrown for 1,931 yards, 11 touchdowns, and four interceptions for the 49ers this season. Christian McCaffrey has rushed for 563 yards and four touchdowns, while Brandon Aiyuk has caught 44 passes for 567 yards and four scores for San Francisco. The San Francisco defense is giving up 18.1 points per game and 280.6 yards per game.

The Arizona Cardinals are 4-6 this season after they defeated the Los Angeles Rams by a score of 27-17 in their last game. Arizona held the Rams to only 256 total yards and forced two turnovers in the win. The Arizona offense is averaging 23 points per game with 220.6 passing yards per game and 113.1 rushing yards per game. Kyler Murray (questionable) has thrown for 2,168 yards, 12 touchdowns, and six interceptions, while also rushing for 359 yards and two touchdowns for the Cardinals this season. James Conner has rushed for 314 yards and three touchdowns, while Marquise Brown has caught 43 passes for 485 yards and three scores for Arizona. The Arizona defense is allowing 25.8 points per game and 357.6 yards per game.

San Francisco is 9-2 ATS in their last 11 games against the NFC and 15-4 ATS in their last 19 Monday games. The under is 13-4 in San Francisco’s last 17 games. Arizona is 2-9 ATS in their last 11 Monday games and 1-6 ATS in their last 7 games against the NFC West. The over is 4-0 in Arizona’s last 4 games. San Francisco is 1-7-1 ATS in these two team's last 9 head-to-head meetings.

Arizona comes into this game with questions surrounding their quarterback, with Kyler Murray questionable to play. Murray missed last week’s game, but Arizona was able to come away with the win. San Francisco has looked very good in their last two weeks and should have no issues in this game if Murray is out. It looks like Murray is trending closer to being out than playing, so I am going to take San Francisco here.

David’s Pick San Francisco -8.5

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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