San Francisco 49ers at Denver Broncos - 9/25/22 NFL Picks and Prediction

Denver Broncos (1-1) vs San Francisco 49ers (1-1)

Game Info: Sunday, September 25, 2022 at 8:20 pm (Empower Field at Mile High)

Betting Odds: Denver Broncos +1.5 -- Over/Under: 43.5 Click Here for the Latest Odds

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The San Francisco 49ers will travel to play the Denver Broncos in Week 3 of the NFL regular season on Sunday night at Mile High Stadium in Denver, Colorado.

The San Francisco 49ers are 1-1 this season after they defeated Seattle by a score of 27-7 in Week 2. San Francisco held Seattle to 216 total yards and forced three turnovers in the win. The San Francisco offense is averaging 18.5 points per game with 169.5 passing yards per game and 182.5 rushing yards per game. Jimmy Garoppolo has thrown for 154 yards and one touchdown for the 49ers this season. Jeff Wilson Jr. has rushed for 106 yards, while Brandon Aiyuk has caught seven passes for 103 yards for San Francisco. The San Francisco defense is giving up 13 points per game and 210 yards per game.

The Denver Broncos are 1-1 this season after they defeated Houston by a score of 16-9 in their last game. Denver really struggled with the Texans in this game, but was able to score 10 unanswered points in the fourth quarter for the win. The Denver offense is averaging 16 points per game with 265.5 passing yards per game and 126 rushing yards per game. Russell Wilson has thrown for 559 yards, two touchdowns, and one interception for the Broncos this season. Javonte Williams has rushed for 118 yards, while Courtland Sutton has caught 11 passes for 194 yards for the Broncos. The Denver defense is allowing 13 points per game and 243.5 yards per game.

San Francisco is 6-1 ATS in their last 7 games and 2-8 ATS in their last 10 Week three games. The under is 5-0 in San Francisco’s last 5 games. Denver is 1-5 ATS in their last 6 games and 4-9 ATS in their last 13 games on grass. The under is 5-2 in Denver’s last 7 home games.

Denver has not looked good in their first two games of this season. The Denver offense sputtered against the Texans last week and will not have to go up against a tough 49ers defense. San Francisco played well against Seattle in Week 2, but this should be a tougher task. Denver has the players to be a good team, but when will they put it together? I like Denver to win this game at home.

David’s Pick Denver +1.5

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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