Seattle Seahawks at San Francisco 49ers - 9/18/22 NFL Picks and Prediction

San Francisco 49ers (0-1) vs Seattle Seahawks (1-0)

Game Info: Sunday, September 18, 2022 at 4:05 pm (Levi's Stadium)

Betting Odds: San Francisco 49ers -9.5 -- Over/Under: 43.5 Click Here for the Latest Odds

Where to Watch: FOX Stream live sports and exclusive originals on ESPN+. Sign up now! Advertisement

The San Francisco 49ers and Seattle Seahawks square off Sunday afternoon in week 2 NFL action at Levi’s Stadium. The San Francisco 49ers look to avoid their first 0-2 start since the 2017 season. The Seattle Seahawks look for their third 2-0 start in the last 4 years. 

The San Francisco 49ers have won their last 4 home games. Trey Lance is completing 46.4 percent of his passes for 164 yards, 0 touchdowns and 1 interception. Jauan Jennings and Brandon Aiyuk have combined for 102 receiving yards on 6 catches, while Ray-Ray McCloud III has 1 reception. The San Francisco 49ers ground game is averaging 176 yards per contest, and Lance leads the way with 54 yards on 13 carries. Defensively, San Francisco is allowing 19 points and 204 yards per game. Talanoa Hufanga leads the San Francisco 49ers with 11 tackles, Nick Bosa has 1 sack and Charvarius Ward has 1 pass deflection.

The Seattle Seahawks have lost 5 of their last 8 road games. Geno Smith is completing 82.1 percent of his passes for 195 yards, 2 touchdowns and 0 interceptions. Will Dissly and Colby Parkinson have combined for 86 receiving yards and 2 touchdowns, while DK Metcalf has 7 receptions. The Seattle Seahawks ground game is averaging 76 yards per contest, and Rashaad Penny leads the way with 60 yards on 12 carries. Defensively, Seattle is allowing 16 points and 433 yards per game. Jordyn Brooks leads the Seattle Seahawks with 12 tackles, Uchenna Nwosu has 1 sack and Tariq Woolen has 1 pass deflection.

The Seahawks are 6-2 ATS in their last 8 games in September and 5-2 ATS in their last 7 games overall. The 49ers are 4-0 ATS in their last 4 home games and 5-1 ATS in their last 6 games overall. The over is 5-2 in Seahawks last 7 games overall. The under is 4-0 in 49ers last 4 games overall. The Seahawks are 7-3 ATS in their last 10 meetings in San Francisco and 15-5-1 ATS in their last 21 meetings.

This is a weird game to cap because we’re still on the fence about both teams. The Seattle Seahawks likely won’t play with the same juice as they did in their opener at home, and against their former quarterback. The San Francisco 49ers also aren’t as bad as they looked last week now that they’re at home and not playing in a monsoon. On paper, this should be a comfortable win for the home team. However, the Seahawks have a physical defense and a powerful ground attack, two things that help you win on the road in this league. The 49ers are still breaking in Lance at quarterback, and it may take some time to really trust this club to start blowing teams out. As I said last week, the Seahawks may not have Russell Wilson anymore, but there’s still talent on this team overall. I’ll take a shot with the points.

Randy’s Pick Seattle Seahawks +9.5

Get Premium Picks Start Winning Now »
The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

Mitch's Take...

NFL, NBA, NHL, NCAAB Best Bets Today Picks & Predictions Monday 12/4/23 | 7 Picks in 5 Minutes

Credit Guaranteed Packages

Packages with Credit Guarantees automatically give you a credit if the package does not turn a profit—the sum of betting all individual picks. THESE ARE NOT PARLAYS UNLESS OTHERWISE CLEARLY STATED. If a credit guaranteed package does not profit, a credit for its full purchase price is automatically issued after picks are graded and verified.

For example, if you purchase a $39.95 package that doesn’t profit, you’ll get a $39.95 credit towards any future purchase(s) on our site. Credits are usually issued within hours of a game’s conclusion, so please allow a few hours for final verification.

To use your credits, log in to your account and add another package or pass to your cart. Credits will automatically reduce what you owe. Any remaining balance will be settled through our payment system, with any leftover credits available future purchases. Credits do not expire.