San Francisco 49ers at Tennessee Titans - 12/23/21 NFL Picks and Predictions

San Francisco 49ers at Tennessee Titans - 12/23/21 NFL Picks and Predictions Photo by Nathan Ray Seebeck-USA TODAY Sports

Tennessee Titans (9-5) vs San Francisco 49ers (8-6)

Game Info: Thursday, December 23, 2021 at 8:20 pm (Nissan Stadium)

Betting Odds: Tennessee Titans +3.5 -- Over/Under: 43.5 Click Here for the Latest Odds

The San Francisco 49ers and Tennessee Titans face off on Thursday Night Football in an NFL showdown at Nissan Stadium. When these two teams last faced off in 2017 it was the 49ers that won 25-23. 

The 49ers come into this game with an 8-6 record overall and they have gone 7-7 against the spread. The 49ers have won two games in a row including the last game against Atlanta Falcons. The offense was strong in that game scoring 31 points and that was enough to cruise to the victory. The 48ers are averaging 25.7 points per game while their defense is giving up 22.4 points per game. Their red zone efficiency is 73.81 percent which is 1st in the NFL. In the last game, Jeff Wilson had an impressive game finishing with 21 carries for 110 yards and a touchdown. In this game, they are going to need to find success running the ball again and they need to wear down the Titans' defense. Deebo Samuel has also been a swiss army knife for this team and he should be a mismatch again. 

On the other side of this matchup is the Tennessee Titans who sit with a 9-5 record overall and they have gone 8-6 against the spread. The Titans have lost three of their last four games including the last game against the Steelers. In that last game against the Titans left too many points on the field not finishing drives. Some good news for the Titans heading into this game is it looks like AJ Brown might be back, and that will be a big boost for this team. Julio Jones is dealing with a hamstring injury and it’s unclear if he will be able to go in this game. Not having Derrick Henry is still a big loss for this team, but D'Onta Foreman has stepped up the last few weeks and made a big impact. 

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The 49ers are 4-0 against the spread in their last four games on grass. The Titans are 5-2 against the spread in their last seven games as an underdog. The over is 4-0 in the last four meetings between the 49ers and Titans. 

The Titans' defense looked good in the last game, and they are going to find success slowing down the 49ers in this game. The 49ers are going to still score a couple of touchdowns, but the Titans' offense will also find success. D'onta Foreman rushed for 108 yards in the last game, and he will find success again in this game. The Titans have done a good job of covering spreads as underdogs, and they are going to do it again in this game. Back the Titans against the spread. 

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Shane’s Pick Titans +3.5

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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