Minnesota Vikings at San Francisco 49ers - 11/28/21 NFL Picks and Predictions

San Francisco 49ers (5-5) vs Minnesota Vikings (5-5)

Game Info: Sunday, November 28, 2021 at 4:25 pm (Levi's Stadium)

Betting Odds: San Francisco 49ers -3 -- Over/Under: 48 Click Here for the Latest Odds

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The Minnesota Vikings and San Francisco 49ers face off on Sunday in a key NFC showdown at Levi’s Stadium. When these two teams faced off in January of 2020 it was the 49ers that won 27-10. 

The Minnesota Vikings come into this game with a 5-5 record and they have gone 6-4 against the spread.The Vikings have been a bit inconsistent, but they are coming off a big win against the Green Bay Packers. Kirk Cousins threw for 341 yards and three touchdowns. Justin Jefferson is quickly becoming one of the league's top receivers and in the last game he had eight receptions for 169 yards and two touchdowns. The Vikings are averaging 25.5 points while their defense is giving up 24.2 points per game. The Vikings won’t have Everson Griffen in this game and that’s a big loss for their defense. 

On the other side of this matchup is the San Francisco 49ers who sit with a 5-5 record and they have gone 4-6 against the spread. The 49ers have won two games in a row and two games against the San Francisco 49ers, they won 31-10. The 49ers are averaging 24.6 points while their defense is giving up 22.2 points per game. Under center for the 49ers is Jimmy Garoppolo and he has thrown for 2,112 yards, 12 touchdowns, and five interceptions. In this game if the 49ers want to come away with a victory, they are going to need the defense to be good. 

The Vikings are 4-0 against the spread in their last four road games. The 49ers are 3-10 against the spread in their last 13 games as a favorite. The over is 11-5 in the Vikings last 16 games against the NFC. The under is 4-0 in the last four meetings in San Francisco. The under is 4-0 in the last  four meetings.

Cousins is playing like one of the best quarterbacks in the NFL, and he is going to have a big game. Look for Cousins and Jefferson to have a big game, and the Vikings will keep it close. Back the Vikings against the spread.

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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