Indianapolis Colts at Buffalo Bills: 11/21/21 NFL Picks and Predictions

Indianapolis Colts at Buffalo Bills: 11/21/21 NFL Picks and Predictions Photo by Robert Scheer/IndyStar / USA TODAY NETWORK

Buffalo Bills (6-3) vs Indianapolis Colts (5-5)

Game Info: Sunday, November 21, 2021 at 1:00 pm (Highmark Stadium)

Betting Odds: Buffalo Bills -7 -- Over/Under: 49.5 Click Here for the Latest Odds

Where to Watch: CBS Stream live sports and exclusive originals on ESPN+. Sign up now! Advertisement

The Indianapolis Colts and Buffalo Bills face off on Sunday in a key AFC showdown at Bills Stadium. When these two teams faced off in January it was the Bills that came away with the 27-24 victory. 

The Colts got out to a very slow start to the season, but they are playing a lot better as of late having won two games in a row. In the last game against the Jaguars the Colts won by six points. The Colts are averaging 26.8 points per game while their defense is giving up 23 points per game. Under center for the Colts is Carson Wentz who has thrown for 2,378 yards, 17 touchdowns, and three interceptions. Jonathan Taylor has become one of the best running backs in the NFL and he has rushed for 937 yards and nine touchdowns. The Colts are pretty banged up but it looks like center Quenton Nelson will be available for this game.

On the other side of this matchup is the Buffalo Bills who sit with a 6-3 record overall but there are clearly some issues with this team. This is the same Bills team that beat the Jaguars by only three points two games ago, and in that game they only scored nine points. The Bills are averaging 31.1 points while their defense has given up only 15 points total. The Bills are ranked second with their offense and the defense is second-ranked. Josh Allen on the season has thrown for 2,602 yards 19 touchdowns, and six interceptions. Stefon Diggs is having another big season out wide catching 56 passes for 750 yards and four touchdowns. 

Get the BEST EXPERT PICKS From Top Handicappers

The Colts are 5-0 against the spread in their last five games played in Week 11. The Bills are 10-2-1 against the spread in their last 13 games in November. The Colts are 4-0 against the spread in their last four games following an against the spread loss. 

I don’t trust this Bills team, and the Colts offense has proven they are good. I expect a big game from Carson Wentz, and even if this game gets into a shootout, the Colts will find enough offensive success. The Colts are going to cover the spread, and throwing a few dollars on the money line isn’t the worst idea. 

$250 Risk Free Bet CLICK HERE

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

Mitch's Take...

Free NFL Parlay For Today 11/28/21 NFL Pick & Prediction NFL Betting

Guaranteed Packages

Guaranteed packages automatically give you a credit if the package does not turn a profit—the sum of betting all individual picks. THESE ARE NOT PARLAYS UNLESS OTHERWISE CLEARLY STATED. If a guaranteed package does not profit, a credit for its full purchase price is automatically issued after picks are graded and verified.

For example, if you purchase a $39.95 package that doesn’t profit, you’ll get a $39.95 credit towards any future purchase(s) on our site. Credits are usually issued within hours of a game’s conclusion, so please allow a few hours for final verification.

To use your credits, log in to your account and add another package or pass to your cart. Credits will automatically reduce what you owe. Any remaining balance will be settled through our payment system, with any leftover credits available future purchases. Credits do not expire.

Dismiss