Arizona Cardinals at Seattle Seahawks - 11/21/21 NFL Picks and Prediction

Arizona Cardinals at Seattle Seahawks - 11/21/21 NFL Picks and Prediction Photo by Michael Chow-Arizona Republic / USA TODAY NETWORK

Seattle Seahawks (3-6) vs Arizona Cardinals (8-2)

Game Info: Sunday, November 21, 2021 at 4:25 pm (Lumen Field)

Betting Odds: Seattle Seahawks -1.5 -- Over/Under: 50.5 Click Here for the Latest Odds

Two NFC West teams will collide when the Arizona Cardinals go on the road and take on the Seattle Seahawks. The Cardinals are 8-2 straight up this season. The Seahawks enter the game with a record of 3-6 due to a period of missed games by their franchise QB. 

Russell Wilson went out for the Seahawks in week 5 of the NFL season on Thursday Night Football. The Seahawks would go on to lose that game against the Rams. They would spend the next few weeks of the season with Geno Smith under center.

With Smith at QB for the injured Wilson, the Seahawks numbers plummeted. They rank 22nd in the league in points per game and are second worse in the league in total yards per game. The offense averages 23 rushing attempts and 29 passing attempts per game..

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Russell Wilson returned last week. The Seahawks were scoreless as they folded to the Packers, 17-0. Wilson struggled, as he went 20/40 for 161 passing yards, zero Touchdowns and two interceptions.

Arizona has faced injuries as well. The most important was to their star QB Kyler Murray who has been excellent when available. Murray has 17 touchdowns compared to seven interceptions and is third on the team in rushing. He’s been an MVP caliber QB for this dangerous Cardinals team.

Arizona was favored by seven points but lost 34-10 against the Carolina Panthers in their last contest. Colt McCoy went 11/20 for 107 passing yards, had zero passing touchdowns, and threw one interception. McCoy suffered a pec strain and left the game. Chris Streveler replaced McCoy and went 6/9 for 36 passing yards and zero passing touchdowns.

The Cardinals’ defense is allowing 18.9 points per game which is top five in the National Football League. Arizona is top 10 in the league in passing yards allowed per game and sacks per game. 

With Wilson back, the Seahawks will play better, but the Seahawks are still 3-8 ATS in their last 11 vs. NFC.

The Cardinals are 4-1 ATS in their last 5 games following an ATS loss. With Murray more probable each day, they will look to give him a chance to warm up here. Arizona will want to continue where they left off and will bounce back with a win here.

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Clayton’s Pick Cardinals ML

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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