Arizona Cardinals at San Francisco 49ers - 11/7/21 NFL Picks and Prediction

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The Arizona Cardinals will travel to face the San Francisco 49ers Sunday afternoon. The 49ers are 3-4 on the season straight up and just 2-5 ATS on the season after beating the Bears. The Cardinals are 7-1 straight up, 6-2 ATS and come into this one with a long injury list. 

This 10th ranked Cardinals passing offense averages 264.9 yards per contest while they are 8thin rushing offense with 128.8 yards per game. Arizona is also  4th in scoring offense with an average of 30.8 points per game. This has been thanks to MVP candidate, Kyler Murray, who has completed 186 of 256 passes for 2,276 yards with 17 touchdowns and seven interceptions on the year. Unfortunately, he is listed as questionable with an ankle injury and did not participate in Thursday’s practice. Wide receiver A.J. Green tested positive for COVID-19, so he will be out. 

Arizona recorded a 17-10 home win over the 49ers on Oct. 10 when Murray passed for 239 yards. This was Murray’s lowest output of the season, showing it doesn’t take a lot to beat the 49ers. The under is 7-3 in the last 10 meetings and the under is 7-3 in Cardinals last 10 games overall.

The 49ers snapped a four game losing streak last weak when they beat the bears on the road. The 49ers are in third place in the NFC West, sitting three games behind Arizona and Los Angeles. 

For the season, the 49ers are 16th in the league in passing offense with 246 yards per game through the air. Quarterback Jimmy Garoppolo has completed 64.2% of his passes for 1,428 yards and six touchdowns to four interceptions. Last time out, he passed for a season-best 322 in the win over the Detroit Lions.

With Kyle Murray not in this game, the Cardinals will have to find another way to score the ball. Points in this one will be hard to come by which is why I like this one to stay under the 47. The first time these two teams met there was no Garoppolo, now there is. The Cardinals are just too injury riddled for me to back them in this match up. I’ll go with San Francisco. 

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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