San Francisco 49ers at Philadelphia Eagles - 9/19/21 NFL Picks and Prediction

Philadelphia Eagles (1-0) vs San Francisco 49ers (1-0)

Game Info: Sunday, September 19, 2021 at 1:00 pm (Lincoln Financial Field)

Betting Odds: Philadelphia Eagles +3 -- Over/Under: 49.5 Click Here for the Latest Odds

The Philadelphia Eagles will host the San Francisco 49ers this Sunday in an NFL regular season battle. The Eagles won 25-20 when they faced off last year.

The 49ers are coming off a 41-33 victory in week one, a game that was a blowout until the end of the fourth quarter. They were able to move the ball at will, racking up 442 yards of total offense. Jimmy Garoppolo threw for 314 yards on just 25 attempts. Trey Lance made a guest appearance in the red zone to throw his first career touchdown, a five-yard strike to Trent Sherfield. San Francisco averaged 4.7 yards per carry for 131 yards and two touchdowns on the ground. Defensively they allowed 430 yards of total offense and 31 first down conversions, however most of that came in the fourth quarter. Dre Greenlaw had a pick-six in the second quarter but was sidelined with a groin injury and will miss 6-to-8 weeks.

 Philadelphia came out of the gate with a convincing 32-6 win at the Atlanta Falcons. Jalen Hurts had a great game, going 27/35 for 264 yards and a touchdown. Hurts also ran seven times for 62 yards. Rookie wideout DeVonta Smith was his top target, hauling in six passes for 71 yards and a touchdown. In total, they accumulated 434 total yards of offense. The defense silenced what is expected to be an exciting Falcons attack, limiting them to 260 yards of total offense. Matt Ryan was limited to 164 yards and no touchdowns in the game, largely due to the immense pressure. The Eagles racked up nine QB hits and three sacks, Javon Hargrave led the way with two.

San Francisco is 3-7 ATS in their last 10 games, 4-6 on the money line, and the over is 5-5.

Philadelphia is 4-6 ATS in their last 10 games, 4-6 on the money line, and the under is 7-3.

This has the makings of a great game, with both teams getting off to strong starts. Philadelphia’s offense seemingly took a huge step forward in Jalen Hurts second season, but it will be interesting to see how they respond against a more potent 49ers defense. With Joey Bosa back up front, you can expect San Fran’ to bring pressure, but the Eagles are well equipped to handle it. The 49ers averaged nearly five yards per carry in their week one win, so the Eagles should be able to find some success with their versatile rushing attack. San Francisco can put up some points, but I expect Philadelphia’s fast defense to come out with some energy in the home opener and get enough stops for the win. Give me the Eagles in Philly.

Joe’s Pick Philadelphia Eagles +3

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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