Buffalo Bills at San Francisco 49ers: 12/7/20 NFL Picks and Prediction

Defensively, Buffalo is allowing their opponents to average 25.6 ppg on 387.8 total yards per game (258.2 passing yds/g; 129.6 rushing yds/g).

The San Francisco 49ers snapped their 3-game losing streak and improved to 5-6 on the season after upsetting the Los Angeles Rams, 23-20, this past Sunday. The San Francisco defense did an outstanding job of slowing down the Los Angeles offensive attack and was able to secure the victory on a game-winning 42-yard FG by Robbie Gould as time expired. San Francisco outgained Los Angeles by a 348-308 margin and forced Los Angeles into committing 4 turnovers in the victory. Leading the way for the 49ers was WR Deebo Samuel who has 11 receptions for 133 yards.

On the season, San Francisco is averaging 23.7 ppg on 382.3 total yards per game (270.0 passing yds/g; 112.3 rushing yds/g). Offensively, San Francisco is led by RB Raheem Mostert who has 346 yards & 2 TD’s on 67 attempts. Mostert returned from injury last week and is also joined in the backfield with Jerick McKinnon (80 att, 315 yards, 5 TD), Jeff Wilson Jr. (50 att, 206 yards, 4 TD), and Tevin Coleman (21 att, 50 yards). QB Nick Mullens (67.5 Comp %, 1,642 yards, 6 TD, 7 INT) will continue to start for the injured Jimmy Garoppolo (67.1 Comp %, 1,096 yards, 7 TD, & 5 INT). The top receiving threats for the 49ers have been George Kittle (37 rec, 474 yards, 2 TD), Brandon Aiyuk (35 rec, 446 yards, 3 TD), Kendrick Bourne (32 rec, 412 yards, 1 TD), and Deebo Samuel (27 rec, 318 yards, TD). The 49ers will be without George Kittle however, they do have a chance of having Brandon Aiyuk back in the lineup.

Defensively, San Francisco is holding their opponents to an average of 23.1 ppg on 326.4 total yards per game (217.6 passing yds/g; 108.7 rushing yds/g).

The Bills are 9-4-2 ATS in their last 15 road games, however, are just 1-4 ATS vs. a team with a losing record. The 49ers are 13-3 ATS in their last 16 Monday games and 7-3 ATS in their last 10 home games vs. a team with a winning road record.

Buffalo comes into with an 8-3 record, however, I haven’t been a huge fan with how the Bills have looked as of late as they weren’t impressive in recent victories against the Jets & Patriots and were a bit off in their win against the Chargers. San Francisco picked up a huge win against the Rams and between the fact that their offense got back two of their main weapons in Raheem Mostert & Deebo Samuel and that I think their defense will have another strong performance, I think the play here to take San Francisco and the points. Good Luck!