San Francisco 49ers at New York Giants - 9/27/20 NFL Picks and Prediction

On the season, San Francisco is averaging 25.5 ppg on 383.0 total yards per game (152.5 rushing yds/g; 230.5 passing yds/g). Jimmy Garoppolo (67.3% Comp %; 390 yards, 4 TD) has been decent. I Garoppolo cannot go, he will be replaced by Nick Mullens who completed 8 of 11 passes for 71 yards, 0 TD, and an INT after filling in for Garoppolo this past Sunday. RB Raheem Mostert has been the 49ers best player this season, leading the team in both rushing (148 yards, TD) & receiving (6 rec, 110 yards, TD. RB Jerick McKinnon, who has looked good in limited opportunities this season (6 car, 101 yards, TD) will start at RB if Mostert cannot go. The leading receivers for the 49ers have been Kendrick Bourne (6 rec, 101 yards), Jordan Reed (9 rec, 62 yards, 2 TD), and George Kittle (4 rec, 44 yards).

Defensively, San Francisco is holding their opponents to an average of 18.5 ppg on 346.5 total yards per game (142.0 rushing yds/g; 204.5 passing yds/g).

The New York Giants dropped to 0-2 on the season after being defeated by the Chicago Bears, 17-13, this past Sunday. New York fell behind by a 17-0 margin early in this game, and although they fought back to make it a one-possession game after Dion Lewis 1-yard TD run early in the 4th quarter, the Giants couldn’t do enough offensively to get the come from behind victory. Leading the way for the Giants was TE Evan Ingram who had 6 receptions for 65 yards.

Similar to the San Francisco 49ers, the Giants suffered some tough injuries which included losing their star RB, Saquon Barkley, for the season due to an ACL tear. Sterling Shepard (toe) was also injured and could miss multiple game depending on the results of his MRI.

On the season, New York is averaging 14.5 ppg on 312.0 total yards per game (52.0 rushing yds/g; 260.0 passing yds/g). QB Daniel Jones has completed 63.0% of his passes for 520 yards, 2 TD, & 3 INT. Dion Lewis (11 car, 21 yards, TD) looks like he is the lead back currently, however, the Giants are bring in Devonta Freeman for a workout on Tuesday and I wouldn’t be surprised if they sign him. The top receivers who are still healthy for the Giants include Darius Slayton (9 rec, 135 yards, 2 TD), Evan Engram (8 rec, 74 yards), and Golden Tate (5 rec, 47 yards).

Defensively, New York is allowing their opponents to average 21.5 ppg on 347.5 total yards per game (138.0 rushing yds/g; 209.5 passing yds/g).

The 49ers are 4-1 ATS in their last 5 games as a favorite and 15-7 ATS in their last 22 games as a road favorite. The Giants are 4-1 ATS in their last 5 games following a straight up loss, however, are just 7-18-1 ATS in their last 26 home games.

San Francisco has piled up injuries through the first two weeks like I have never seen and although they will be missing many key players, no injury is as impactful than the Giants losing Saquon Barkley for the season. San Francisco will still have some solid offensive weapons with George Kittle and Jerick McKinnon and I do not mind Nick Mullens under center if Jimmy Garoppolo can't go. Daniel Jones has been good for the Giants, however, I think the Giants offense will continue to have trouble putting points up on the board in this one and I think that the San Francisco offense does enough for the 49ers to cover. Good Luck.