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New Orleans Pelicans vs Memphis Grizzlies Prediction 10/22/2025 Today’s NBA Picks

Oct 17, 2025; Miami, Florida, USA;  Memphis Grizzlies guard Ja Morant (12) who did not play due to injury, leaves the court after the Memphis Grizzlies defeat the Miami Heat at Kaseya Center. Mandatory Credit: Jim Rassol-Imagn Images

Oct 17, 2025; Miami, Florida, USA; Memphis Grizzlies guard Ja Morant (12) who did not play due to injury, leaves the court after the Memphis Grizzlies defeat the Miami Heat at Kaseya Center. Mandatory Credit: Jim Rassol-Imagn Images

MATCHUP New Orleans Pelicans Memphis Grizzlies
Team Records 0-1 1-0
Where FedExForum, Memphis, TN
When Wednesday, October 22, 2025
Time 08:00 PM EDT
TV GCSEN
The New Orleans Pelicans and Memphis Grizzlies meet Wednesday in NBA action at the FedExForum. Here’s a New Orleans Pelicans vs Memphis Grizzlies Prediction. This article will include a New Orleans Pelicans vs Memphis Grizzlies Pick.

New Orleans Pelicans Betting Preview


The New Orleans Pelicans won 21 games last season and have made the playoffs three times since the 2015-16 season. Coach Willie Green enters his fifth year with the franchise.

The Pelicans have been a talented team over the years, but they’ve underachieved and dealt with injuries. Zion Williamson looks to be in shape for once, and that’s a big deal if he can play an entire season. Trey Murphy III and Herbert Jones are two of the more underrated players in the league, and we know Jordan Poole is a bucket getter. The addition of Kevon Looney provides depth, and Yves Missi is coming off a strong rookie season. I’m also excited to see Derik Queen in the league. The Pelicans have players to be competitive even in the west, it’s just a matter of Zion taking his craft seriously and leading the way.

Memphis Grizzlies Betting Preview


The Memphis Grizzlies won 48 games last season and have made the playoffs in four of the last five seasons. The Grizzlies have just one playoff series win since the 2015-16 season.

If the Grizzlies are going to make this season different, Ja Morant has to play a full season. Suspensions and injuries have prevented Morant from playing consistently, as he’s played no more than 67 games in a full season. Jaren Jackson Jr. should have more on his plate with Desmond Bane no longer around and Zach Edey has a chance to become a beast with a season under his belt. Not sure if I’m a big fan of the Grizzlies depth, but a full 82 games from Morant will keep them in the thick of the playoff race.

Why the Memphis Grizzlies will win

Why the New Orleans Pelicans will win

Total Points Facts

New Orleans Pelicans vs Memphis Grizzlies Injury Report


The Grizzlies will be without Vince Williams Jr., Ty Jerome, Scotty Pippen Jr., Brandon Clarke, and Zach Edey.

The Pelicans will be without Dejounte Murray and Kevon Looney. Karlo Matkovic is doubtful with an elbow injury.

New Orleans Pelicans vs Memphis Grizzlies Prediction


You’d think the Grizzlies would win this game at home, but I’m not thrilled to lay chalk with an injury report that large this early in the season. The Grizzlies are going through it, and that’s not even mentioning they still have to learn how to play without Desmond Bane. The Pelicans haven’t won much over the years, but they have players and a healthy and motivated Zion could do wonders. The Grizzlies are too undermanned to back without seeing some sort of sample size. Give me the Pels and the points.

Randy Chambers's Pick: New Orleans Pelicans +4.5

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