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Cleveland Cavaliers vs Detroit Pistons Prediction 10/27/2025 Today’s NBA Picks

Oct 24, 2025; Houston, Texas, USA; Detroit Pistons guard Cade Cunningham (2) drives with the ball as Houston Rockets forward Jabari Smith Jr. (10) defends during the fourth quarter at Toyota Center. Mandatory Credit: Troy Taormina-Imagn Images

Oct 24, 2025; Houston, Texas, USA; Detroit Pistons guard Cade Cunningham (2) drives with the ball as Houston Rockets forward Jabari Smith Jr. (10) defends during the fourth quarter at Toyota Center. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP Cleveland Cavaliers Detroit Pistons
Team Records 3-1 2-2
Where Little Caesars Arena, Detroit, MI
When Monday, October 27, 2025
Time 07:00 PM EDT
TV Peacock

The Cleveland Cavaliers pay a visit to the Detroit Pistons at Little Caesars Arena on Monday night. Here’s a Cleveland Cavaliers vs Detroit Pistons Prediction. This article will include a Cleveland Cavaliers vs Detroit Pistons Pick.

Cleveland Cavaliers Betting Preview 

The Cleveland Cavaliers have won two of their first three games of the season and they will be eager to build some momentum after last night’s 118-113 home win over the Bucks. Donovan Mitchell led the team with 24 points and four assists on nine of 20 shooting, Evan Mobley added 23 points with eight rebounds, six assists and three steals, Sam Merrill contributed 17 points while De’Andre Hunter chipped in with 16 points.

As a team, the Cavaliers shot 44 percent from the field and 12 of 40 from the 3-point line as they poured in 36 points in the second quarter to take an early 18-point lead. However, they allowed the Bucks back into the contest and needed to go on a crucial 7-0 run midway through the fourth quarter to pull away and escape with the narrow win at home in the end. 

Detroit Pistons Betting Preview 

Meanwhile, the Detroit Pistons are in similar form as they are now gunning for a third straight victory after outlasting the Celtics in a 119-113 home win on Sunday night. Cade Cunningham led the team in scoring with 25 points and eight assists on eight of 18 shooting. Jalen Duren added 24 points with 17 rebounds and two blocks, Ausar Thompson tallied 21 points with 12 rebounds, and Tobias Harris chipped in with 18 points, eight rebounds, and four assists.

As a team, the Pistons shot 42 percent from the field and nine of 34 from the 3-point line as they dominated the second quarter by 36-25 to erase an early 17-point deficit and lead by as many as 15 points. They survived a late scare from the Celtics, who cut the lead to just three points with 2:57 left on the clock.

Why the Detroit Pistons will win

Why the Cleveland Cavaliers will win

Total Points Facts

Cleveland Cavaliers vs Detroit Pistons Prediction

The Cavaliers are still missing a couple key players in Max Strus and Darius Garland, while the Pistons have already ruled out Jaden Ivey, Marcus Sasser and Caris LeVert. The Cavaliers beat the Pistons in three of four meetings last season, and they were good enough to take down the Bucks in a gritty win last night. But it’s going to be tough to replicate that effort on zero days’ rest against this improved Pistons team, who just beat the Celtics.

The Cavaliers have opened as slight favorites on the road, but I think they’re getting a bit too much respect from the bookies in this spot, especially as they’re still missing Garland, who is a key cog in their offense. This should be a tight contest, but I am leaning towards the Pistons to pull off the minor upset in front of their home fans in this spot.

Peter Tran's Pick: Detroit +2.5

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