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Charlotte Hornets vs Philadelphia 76ers Prediction 10/25/2025 Today’s NBA Picks

Oct 15, 2025; Greensboro, North Carolina, USA; Charlotte Hornets guard LaMelo Ball (1) rubs his wrist while waiting to inbound the basketball during the second half against the Memphis Grizzlies at First Horizon Coliseum. Mandatory Credit: Brian Westerholt-Imagn Images

Oct 15, 2025; Greensboro, North Carolina, USA; Charlotte Hornets guard LaMelo Ball (1) rubs his wrist while waiting to inbound the basketball during the second half against the Memphis Grizzlies at First Horizon Coliseum. Mandatory Credit: Brian Westerholt-Imagn Images

Charlotte (1-0) vs Philadelphia (1-0)

October 25, 2025 at 07:30 PM EDT

The Line: Betting Odds: Philadelphia -6.5 — Over/Under: +232.5

(Get latest betting odds)

The Charlotte Hornets pay a visit to the Philadelphia 76ers at the Wells Fargo Center on Saturday night. Here’s a Charlotte Hornets vs Philadelphia 76ers Prediction. This article will include a Charlotte Hornets vs Philadelphia 76ers Pick.

Charlotte Hornets Betting Preview 

The Charlotte Hornets will be aiming for a second straight win after making light work of the rebuilding Nets in a 136-117 home win on Wednesday night. Brandon Miller led the team in scoring with 25 points and seven assists, LaMelo Ball added 20 points with eight assists, Miles Bridges tallied 18 points with 11 rebounds and four assists while Collin Sexton chipped in with 15 points off the bench.

As a team, the Hornets shot 53 percent from the field and 17 of 36 from the 3-point line as they jumped all over the Nets from the start and exploded for 77 points in the first half to open up a 22-point lead. This was more than enough to hold off the Nets who made a bit of a run in the second half. 

Philadelphia 76ers Betting Preview 

Meanwhile, the Philadelphia 76ers are in similar shape as they too will be gunning for a second straight victory after outlasting the Celtics in a 117-116 road win on Wednesday. Tyrese Maxey drained seven 3-pointers to lead the team with 40 points and six assists on 13 of 24 shooting, VJ Edgecombe added 34 points with seven rebounds and three assists while Dominick Barlow chipped in with 13 points, eight rebounds and five assists.

As a team, the 76ers shot 45 percent from the field and 16 of 40 from the 3-point line as they blew an early lead. They looked to be in deep trouble when they trailed by 13 points in the fourth quarter before they rallied behind Maxey to run down the Celtics with time to spare in the end. 

Why the Philadelphia 76ers will win

  • The 76ers have won each of their last 10 night games against the Hornets.
  • The Hornets have lost each of their last nine road games.
  • The Hornets have failed to cover the spread in 10 of their last 12 night games.
  • The favorites have covered the spread in five of the 76ers’ last six games at Xfinity Mobile Arena.

Why the Charlotte Hornets will win

  • The 76ers have lost each of their last eight home games.
  • The road team has won six of the 76ers’ last seven games.
  • The 76ers have failed to cover the spread in 17 of their last 18 games as home favorites.
  • The Hornets have covered the spread in each of their last seven night games against the 76ers following a home win.

Total Points Facts

  • Each of the Hornets’ last six night games on the first leg of a back-to-back have gone UNDER the total points line.
  • Four of the 76ers’ last five home openers against Eastern Conference opponents have gone UNDER the total points line.

Philadelphia 76ers Player Facts

  • Tyrese Maxey ranks 1st amongst qualified players for fast break points per game (10.0) this season.
  • VJ Edgecombe ranks T5th amongst qualified players for three-pointers made Per Game (5.0) this season.

Charlotte Hornets Player Facts

  • Kon Knueppel ranks T7th amongst qualified players for 3P% (75.0%) this season.
  • Miles Bridges is one of only seven qualified players in the league averaging a double-double while shooting over 40% from three this season.

Matchup/League Facts

  • The 76ers rank 1st in the league for opponent three-point percentage this season (25.6%).
  • The 76ers rank 30th in the league for opponent free throw percentage this season (88.5%).
  • The Hornets rank 1st in the league for assists per game this season (33.0).
  • The Hornets rank 1st in the league for three-point percentage this season (47.2%).

Charlotte Hornets vs Philadelphia 76ers Prediction

The Hornets should have a full roster for this game with no player listed on the injury report, while the 76ers have already ruled out Paul George, Trendon Watford, Justin Edwards and Jared McCain. The Hornets looked great in their season opener, albeit against a lottery-bound team in the Nets, while the 76ers will be full of confidence after taking down the Celtics in a solid comeback win in their last outing.

I wouldn’t be surprised if the Hornets are able to build some momentum with a minor upset win on the road in this spot. But I feel the line is just short enough for me to stick with the 76ers to get the win behind another big game from Maxey. He was fantastic against a shorthanded Celtics squad. 

Peter Tran's Pick: Philadelphia -6.5

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