Denver Nuggets vs Portland Trail Blazers Prediction 3/21/25 NBA Picks

Portland Trail Blazers Betting Preview 

The Portland Trail Blazers beat the Grizzlies and Wizards, and they play the Celtics, Cavs, and Kings next. The Trail Blazers keep playing spoiler, which includes three straight home wins. 

The Portland Trail Blazers are averaging 110.6 points on 45.1 percent shooting and allowing 114.2 points on 46.9 percent shooting. Anfernee Simons is averaging 19.5 points and 2.7 rebounds, while Shaedon Sharpe is averaging 17.5 points and 4.1 rebounds. Deni Avdija is the third double-digit scorer and Deandre Ayton is grabbing 10.2 rebounds. The Portland Trail Blazers are shooting 34.6 percent from beyond the arc and 76.8 percent from the free-throw line. The Portland Trail Blazers are allowing 36.2 percent shooting from deep and are grabbing 44.3 rebounds per game.

Why the Portland Trail Blazers will win

• The Trail Blazers have won each of their last seven games at Moda Center following a win.
• The Trail Blazers have covered the spread in each of their last eight games at Moda Center following a win.
• The Nuggets have failed to cover the spread in eight of their last 10 games.

Why the Denver Nuggets will win

• The Trail Blazers have lost each of their last 13 Friday night games against Western Conference opponents that held a winning record.
• The Nuggets have won each of their last five games as underdogs against Western Conference opponents following a loss.
• The Trail Blazers have failed to cover the spread in eight of their last nine games as favorites against Northwest Division opponents.
• The Nuggets have covered the spread in each of their last four road games following a loss.

Denver Nuggets vs Portland Trail Blazers Injury Report 

The Trail Blazers won’t have Deandre Ayton, Robert Williams III, Jerami Grant, and Jabari Walker.

The Nuggets will be without DaRon Holmes II, Nikola Jokic, and Julian Strawther. Jamal Murray is questionable with an ankle injury.

Denver Nuggets vs Portland Trail Blazers Prediction

I don’t love the Trail Blazers in the favorite role and it’s a spot we don’t see often. This will be just the 11th time since Christmas when the Trail Blazers are favored. The Trail Blazers have won eight straight games as a favorite and are 6-2 ATS in those wins. This has more to do with the Nuggets' injuries, as they’re still down Jokic and could be without Murray. The Trail Blazers continue to play inspired ball and they’re at their best at home where 19 of their 31 wins have come. Given the injury report and the Trail Blazers winning when they’re expected to, I’ll lay the bucket with Portland at home.