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Chicago Fire vs San Diego FC San Diego FC Prediction 07/12/2025 Picks

Jun 2, 2018; Chicago, IL, USA; San Jose Earthquakes forward Tommy Thompson (22) goes for a header against Chicago Fire forward Diego Campos (17) during the second half at Bridgeview Stadium. Mandatory Credit: Kamil Krzaczynski-Imagn Images

Jun 2, 2018; Chicago, IL, USA; San Jose Earthquakes forward Tommy Thompson (22) goes for a header against Chicago Fire forward Diego Campos (17) during the second half at Bridgeview Stadium. Mandatory Credit: Kamil Krzaczynski-Imagn Images

San Diego FC (12-3-6) vs Chicago (8-4-8)

July 12, 2025 at 08:30 PM EDT

The Line: Betting Odds: Chicago Fire +150 / San Diego FC +145 — Over/Under: 3.25

(Get latest betting odds)

San Diego FC will visit Chicago Fire on Saturday, July 12th, 2025, at the Soldier Field in this Week 22 Major League Soccer matchup. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego FC vs Chicago Fire Prediction. We will examine:
Chicago Fire recent form and player performance
San Diego FC recent form and player performance
Recent betting trends and streaks involving Chicago Fire
Recent betting trends and streaks involving San Diego FC
Recent betting trends in games played between the San Diego FC and Chicago Fire
A summary that ties it all together and produces a favorable betting outcome for the San Diego FC vs Chicago Fire game

Chicago Fire Preview

Chicago has 28 points this season and are sitting on the 9th place of the Eastern Conference. Chicago has an 8-8-4 record this season and have a 2-3-4 home record. Chicago is coming off a 1-3 road defeat by Minnesota, and are 1-4 in their last 5 games. Over is 10-2 in their last 12 games. 

Chicago is averaging 1.95 goals per game, while allowing 1.80 goals per game. Hugo Cuypers is the top scorer for Chicago this season with 10 total goals.

San Diego FC Preview

San Diego has 39 points this season and are sitting on the first place of the Western Conference. San Diego has a 12-6-3 record this season, and have a 6-4 road record. San Diego is coming off a 3-4 home defeat by Houston, which ended their previous four-game winning streak. They are 4-1 in their last 5 road games and Over is 4-0 in their last 3 games. 

San Diego is averaging 2.10 goals per game, while allowing 1.38 goals per game. Milan Iloski is the top scorer for San Diego this season with 9 total goals.

Why San Diego FC will win

San Diego FC has won four of its last five MLS games.
San Diego FC has won four of its last five MLS away games.
San Diego FC has won each of its last three MLS away games.
San Diego FC has won three of its last four MLS games as a favorite following a loss.
The away team has won each of San Diego FC’s last four MLS games.
The away team has won four of Chicago’s last six MLS games.
Chicago has lost three of its last four MLS games.

Total Points Facts

The ‘Both Teams to Score’ market has hit in each of San Diego FC’s last four MLS games.
The ‘Both Teams to Score’ market has hit in 15 of Chicago’s last 18 MLS night games.
The ‘Over 2.5 Goals’ market has hit in eight of San Diego FC’s last nine MLS away games.
The ‘Over 2.5 Goals’ market has hit in 10 of Chicago’s last 12 MLS night games as an underdog.
The ‘Over 4.5 Goals’ market has hit in each of San Diego FC’s last three MLS away games.

San Diego FC vs Chicago Fire Prediction

In this San Diego FC vs Chicago Fire Prediction, both teams are coming at a pickem price. San Diego has 11 more points than Chicago, they have six road wins, while Chicago has only two, and have been in excellent road form, with a 4-1 record in their last 5 road games. Chicago has also been in poor form lately, with a 1-4 record in their last 5 games, and I like San Diego to not lose today. Take San Diego FC PK in this one.

Nikos Lagouretos's Pick: San Diego FC PK

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