Yankees vs Orioles Prediction 9/21/2025 Today’s MLB Picks

In this article we will formulate a Yankees vs Orioles prediction for this MLB game on Sunday, September 21st at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

New York Yankees Betting Preview

The New York Yankees are 87-68 this year after they won two of the first three games in this series by scores of 7-0, 2-4, and 6-1. In their game three win, New York scored the first six runs and cruised to the easy victory. The Yankees recorded 10 hits in the game and they were led by Stanton, who went 1-3 with one home run and three RBIs in the win. New York started Rodon, who allowed four hits and one earned run over 7.0 innings for the win, while Weaver and Bednar closed out the game. 

Prior to this series, the Yankees won two out of three against the Twins and two out of three against the Red Sox. New York has won seven of their last ten games and they are second in the AL East standings. The New York pitching staff has a 4.00 ERA with a 1.26 WHIP and a .232 opponent batting average, while the offense has scored 809 runs with a .250 batting average and a .330 on base percentage this season. Aaron Judge has led New York with 49 home runs and 105 RBIs, while Cody Bellinger has added 29 home runs and 97 RBIs this year. The projected starting pitcher for New York is Cam Schlittler, who is 3-3 with a 3.41 ERA and a 1.35 WHIP over 60.2 innings pitched this year.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 73-82 this season after they lost game three by a score of 6-1 on Saturday night. Baltimore never had a chance in the game, but did score in the seventh to avoid the shutout. The Orioles recorded four hits in the game and they were led by Mayo, who went 2-3 with one RBI in the loss. Baltimore started Sugano, who allowed six hits and four earned runs over 3.0 innings for the loss, while Castillo and Cano each allowed one earned run in relief. 

Prior to this series, the Orioles won all three against the White Sox, but lost all three against the Blue Jays before that. Baltimore has won four of their last six games and they are last in the AL East standings. The Baltimore pitching staff has a 4.60 ERA with a 1.37 WHIP and a .259 opponent batting average, while their offense has scored 655 runs with a .238 batting average and a .306 on base percentage this season. Jackson Holliday has led Baltimore with 17 home runs and 55 RBIs, while Gunnar Henderson has added 16 home runs and 65 RBIs this year. The projected starting pitcher for Baltimore is Kyle Bradish, who is 1-1 with a 2.45 ERA and a 1.09 WHIP over 22.0 innings pitched this season.

Why the Orioles will beat the Yankees 

The Orioles have won four of their last five games as home underdogs against the Yankees following a loss.
The Yankees have lost four of their last five games as road favorites against the Orioles following a win.
The Orioles have covered the run line in 11 of their last 13 games as underdogs against the Yankees following a home loss.
The Yankees have failed to cover the run line in nine of their last 11 games as road favorites against the Orioles following a win.

Why the Yankees will beat the Orioles 

The Orioles have lost nine of their last 10 games against AL East opponents that held a winning record.
The road team has won five of the Orioles’ last six games.
The road team has covered the run line in five of the Orioles’ last six games.
The Orioles have failed to cover the run line in three of their last four games at Oriole Park at Camden Yards.
The Orioles have trailed after 3 innings in four of their last five games at Oriole Park at Camden Yards against opponents that held a winning record.
The Orioles have trailed after 5 innings in four of their last five home games against opponents that held a winning record.
The Orioles have lost the first inning in four of their last five games as home underdogs against AL East opponents.

Total Runs Facts

Each of the Orioles’ last 12 home games after playing the previous day have gone UNDER the total runs line.
Each of the Yankees’ last six games as favorites against the Orioles have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last four day games at Oriole Park at Camden Yards.
The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Yankees’ last seven games against AL East opponents.

Baltimore Orioles Player Prop Facts

Kyle Bradish has recorded seven or more strikeouts in five of his last six appearances with the Orioles as underdogs against AL opponents.
Gunnar Henderson has recorded at least one hit in each of the Orioles’ last nine games against the Yankees at Oriole Park at Camden Yards.
Dylan Carlson has recorded a Double in each of his last three appearances with the Orioles as home underdogs against AL East opponents.
Gary Sanchez has hit a home run in two of his last three appearances with the Orioles as underdogs against AL opponents.

New York Yankees Player Prop Facts

Aaron Judge has hit a home run in each of the Yankees’ last two day games against opponents that held a losing record.
Aaron Judge has recorded at least one hit in each of his last 10 Sunday appearances against teams that held a losing record.
Amed Rosario has recorded a Double in three of his last four road appearances against AL East opponents that held a losing record. 

Yankees vs Orioles Prediction 

New York continues to play very well over the last few weeks and they are now just two games behind Toronto in the AL East. The Yankees are 43-37 on the road this year, while the Orioles are 37-40 at home. Baltimore is also playing well over the last two weeks and they are starting Bradish, who has allowed two earned runs or fewer in four straight starts. New York is going with Schlittler, who has allowed four earned runs in two of his last three outings. Take the over here.