White Sox vs Red Sox Prediction 4/20/25 MLB Picks

In this article we will formulate a White Sox vs Red Sox prediction for this MLB game on Sunday, April 20th at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 4-16 this season and they have lost the first two games in this series by scores of 10-3 and 4-3. In that game two loss, the White Sox scored three runs in the seventh inning to tie the game, but couldn’t find anymore offense for the loss. The White Sox recorded seven hits and they committed one error in the game, while they were led by Robert Jr., who went 1-3 with one home run, two RBIs, and two walks in the loss. Chicago started Smith, who allowed four hits and three earned runs over 4.2 innings, while Vasil picked up the loss in the 10th inning. 

Prior to this series, the White Sox lost all three against the Athletics, but did win two out of three against the Red Sox before that. Chicago has lost six games in a row and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.51 ERA with a 1.35 WHIP and a .239 opponent batting average, while the offense has scored 60 runs with a .194 batting average and a .266 on base percentage this season. Brooks Baldwin has led Chicago with two home runs and nine RBIs, while Andrew Vaughn has added two home runs and eight RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 1-3 with a 7.56 ERA and a 1.50 WHIP over 16.2 innings pitched this season. 

Boston Red Sox Betting Preview

The Boston Red Sox are 12-10 this year after they won game two in this series by a score 4-3. Boston scored three runs in the fifth to take a 3-0 lead, but they couldn’t hold onto the lead, before getting the win in the 10th. The Red Sox recorded seven hits and they committed one error in the game, while they were led by Devers, who went 1-4 with one home run, three RBIs, and one walk in the win. Boston started Crochet, who allowed just four hits in 6.0 innings, while Weissert allowed two hits and three earned runs in the seventh. 

Prior to this series, the Red Sox won two out of three against the Rays, but lost two out of three against the White Sox before that. Boston has won four games in a row and they are currently third in the AL East standings. The Boston pitching staff has a 3.99 ERA with a 1.29 WHIP and a .253 opponent batting average, while their offense has scored 100 runs with a .249 batting average and a .326 on base percentage this season. Alex Bregman has led Boston with four home runs and 16 RBIs, while Trevor Story has added five home runs and 14 RBIs this year. The projected starting pitcher for Boston is Tanner Houck, who is 0-2 with a 9.16 ERA and a 1.93 WHIP over 18.2 innings pitched this year. 

Why the Red Sox will beat the White Sox 

• The White Sox have lost each of their last eight road games against American League opponents.
• The Red Sox have won each of their last four games.
• The White Sox have failed to cover the run line in five of their last six games as underdogs.
• The Red Sox have covered the run line in three of their last four home games after going to extra innings.
• The White Sox have trailed after 5 innings in each of their last four games at Fenway Park against American League opponents that held a winning record.
• The White Sox have trailed after 3 innings in three of their last four road games against American League opponents.

Total Runs Facts

• Each of the Red Sox’s last five home games after playing the previous day have gone UNDER the total runs line.
• Four of the White Sox’s last five games after going to extra innings have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six day games between the White Sox and Red Sox at Fenway Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last eight Sunday games against AL East opponents.

Boston Red Sox Player Prop Facts

• Trevor Story has hit at least one home run in two of the Red Sox’s last three games as favorites.
• Trevor Story has recorded at least one Single in each of the Red Sox’s last seven games against the White Sox.
• Jarren Duran has scored at least one run in 10 of his last 12 appearances in day games against teams that held a losing record.
• Trevor Story has recorded at least one hit in each of the Red Sox’s last seven games against the White Sox.
• Masataka Yoshida has recorded a Double in each of his last three appearances in day games against AL Central teams that held a losing record.
• Connor Wong has recorded an RBI in each of his last four home appearances against AL Central opponents.

Chicago White Sox Player Prop Facts

• Luis Robert has hit a home run in two of his last three appearances with the White Sox as underdogs against the Red Sox.
• Luis Robert has recorded at least one RBI in four of his last five appearances against the Red Sox.
• Luis Robert has scored at least one run in six of his last seven appearances in day games against AL East teams that held a winning record.
• Andrew Vaughn has recorded at least one Single in four of the White Sox’s last five games against AL East opponents that held a winning record.
• Andrew Benintendi has recorded at least one hit in eight of his last nine appearances against former teams.

White Sox vs Red Sox Prediction 

Boston comes into this matchup looking for their fifth win in a row and their pitching staff has allowed just six runs in their last three games. The Red Sox are 6-3 at home this year, while the White Sox are 0-8 on the road. Chicago has played Boston pretty tough in five games so far this season, but I have no confidence in them on the road. I don’t like either starting pitcher in this game, but I will side with the Red Sox on the run line, as we continue to fade Chicago away from home. 

David Racey's Pick: Red Sox -1.5