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White Sox vs Rays Prediction 07/22/2025 Picks

Jul 19, 2025; Tampa, Florida, USA; Tampa Bay Rays third baseman Junior Caminero (13) throws to first base against the Baltimore Orioles in the sixth inning at George M. Steinbrenner Field. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

Jul 19, 2025; Tampa, Florida, USA; Tampa Bay Rays third baseman Junior Caminero (13) throws to first base against the Baltimore Orioles in the sixth inning at George M. Steinbrenner Field. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

Chicago (36-65) vs Tampa Bay (52-49)

July 22, 2025 at 07:05 PM EDT

The Line: Betting Odds: Tampa Bay — Over/Under:

(Get latest betting odds)

In this article, we will formulate a White Sox vs Rays prediction for this MLB game on Tuesday, July 22nd at George M. Steinbrenner Field in Tampa, Florida. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 36-65 this season after they won game one against the Rays by a score of 8-3 on Monday. Chicago scored six runs in the first three innings, and they cruised to the easy win. The White Sox recorded 11 hits and they committed two errors in the game, while they were led by Baldwin, who went 1-4 with one home run and three RBIs in the win. Chicago started Burke, who allowed three hits and zero earned runs over 4.0 innings, while Gilbert picked up the win in relief. 

Prior to this series, the White Sox won all three against the Pirates, but did lose three out of four against the Guardians before that. Chicago has won four games in a row, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.04 ERA with a 1.37 WHIP and a .250 opponent batting average, while the offense has scored 367 runs with a .224 batting average and a .298 on-base percentage this season. Miguel Vargas has led Chicago with 12 home runs and 40 RBIs, while Andrew Benintendi has added 11 home runs and 37 RBIs this year. The projected starting pitcher for Chicago is Davis Martin, who is 2-7 with a 3.79 ERA and a 1.23 WHIP over 80.2 innings pitched this season. 

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 52-49 this year after they lost game one by a score of 8-3 to open the series. Tampa Bay cut the deficit to 6-2 in the fourth inning, but allowed two more in the fifth for the loss. The Rays recorded five hits in the game, and they were led by Walls, who went 1-4 with two RBIs in the loss. Tampa Bay started Baz, who allowed eight hits and eight earned runs over 4.0 innings for the loss, while Kelly and Englert pitched two scoreless innings each. 

Prior to this series, the Rays won two out of three against the Orioles, but did lose all four against the Red Sox before that. Tampa Bay has lost six of its last eight games, and they are currently fourth in the AL East standings. The Tampa Bay pitching staff has a 3.80 ERA with a 1.20 WHIP and a .237 opponent batting average, while the offense has scored 470 runs with a .257 batting average and a .320 on-base percentage this season. Junior Caminero has led Tampa Bay with 25 home runs and 65 RBIs, while Brandon Lowe has added 19 home runs and 50 RBIs for the Rays this year. The projected starting pitcher for Tampa Bay is Drew Rasmussen, who is 7-5 with a 2.86 ERA and a 1.03 WHIP over 91.1 innings pitched this year. 

Why the Rays will beat the White Sox

The White Sox have lost eight of their last nine night games against teams that held a winning record.
The Rays have won seven of their last nine games against American League opponents following a home loss.
The White Sox have failed to cover the run line in five of their last six games against American League opponents following a win.
The Rays have covered the run line in six of their last eight games against AL Central opponents following a loss.

Total Runs Facts

Nine of the White Sox’s last 11 games against AL East opponents have gone UNDER the total runs line.
Four of the Rays’ last five games after playing the previous day have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last seven night games between the White Sox and Rays.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last six Tuesday games against American League opponents.

White Sox vs Rays Prediction 

Chicago comes into this contest looking for their fifth straight win, as they are playing some of their best ball of the season. The White Sox are just 15-36 on the road this year, while the Rays are 30-27 at home. Tampa Bay continues to struggle in recent games, but they are starting Rasmussen, who has been very good and is expected to handle a typical starter’s workload. The Sox are going with Martin, who is coming off the IL and hasn’t pitched since June 12th. Take the Rays -1.5 here. 

David Racey's Pick: Rays -1.5

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