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White Sox vs Pirates Prediction 07/20/2025 Picks

Jul 18, 2025; Pittsburgh, Pennsylvania, USA;  Chicago White Sox third baseman Miguel Vargas (20) takes a throw to retire Pittsburgh Pirates shortstop Liover Peguero (not pictured) during the eighth inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

Jul 18, 2025; Pittsburgh, Pennsylvania, USA; Chicago White Sox third baseman Miguel Vargas (20) takes a throw to retire Pittsburgh Pirates shortstop Liover Peguero (not pictured) during the eighth inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

Chicago (34-65) vs Pittsburgh (39-60)

July 20, 2025 at 01:35 PM EDT

The Line: Betting Odds: Pittsburgh -1.5 — Over/Under: +8.5

(Get latest betting odds)

In this article, we will formulate a White Sox vs Pirates prediction for this MLB game on Sunday, July 20th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 34-65 this year after they won the first two games in this series by scores of 10-1 and 10-4. In their game two win, Chicago trailed 4-2 in the fifth, but they scored the last eight runs in the game for the win. The White Sox recorded 13 hits in the game, and they were led by Sosa and Tauchman, who both had three RBIs in the win. Chicago started Houser, who allowed 10 hits and three earned runs over 4.1 innings, while Gilbert picked up the win in relief. 

Prior to this series, the White Sox lost three out of four against the Guardians and two out of three against the Blue Jays. Chicago has won three of their last five games, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.10 ERA with a 1.38 WHIP and a .252 opponent batting average, while the offense has scored 352 runs with a .222 batting average and a .297 on-base percentage this season. Miguel Vargas has led Chicago with 10 home runs and 35 RBIs, while Andrew Benintendi has added 11 home runs and 37 RBIs this year. The projected starting pitcher for Chicago is Aaron Civale, who is 1-6 with a 5.30 ERA and a 1.48 WHIP over 52.2 innings pitched this year. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 39-60 this season after they lost game two by a score of 10-4 on Saturday night. Pittsburgh led 3-0 and 4-2, but they fell apart in the middle innings for the loss. The Pirates recorded 13 hits and they committed one error in the game, while they were led by Hayes, who went 1-3 with two RBIs in the loss. Pittsburgh started Burrows, who allowed three hits and two earned runs over 5.0 innings, while Ferguson allowed four earned runs for the loss. 

Prior to this series, the Pirates lost two out of three against the Twins and were swept by the Royals in three games. Pittsburgh has lost 10 of its last 11 games, and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 3.86 ERA with a 1.22 WHIP and a .236 opponent batting average, while their offense has scored 331 runs with a .230 batting average and a .300 on-base percentage this season. Oneil Cruz has led Pittsburgh with 16 home runs and 38 RBIs, while Bryan Reynolds has added 10 home runs and 46 RBIs this year. The projected starting pitcher for Pittsburgh is Andrew Heaney, who is 4-8 with a 4.59 ERA and a 1.26 WHIP over 98.0 innings pitched this season. 

Why the Pirates will beat the White Sox

The White Sox have lost each of their last six day games following a road win.
The home team has won 16 of the Pirates’ last 19 games.
The White Sox have failed to cover the run line in each of their last four day games against National League opponents following a road win.
The Pirates have covered the run line in nine of their last 10 Sunday games against teams that held a losing record.
The White Sox have trailed after 5 innings in four of their last five day games against National League opponents that held a losing record.

Why the White Sox will beat the Pirates

The Pirates have lost each of their last four games as home favorites against AL Central opponents.
The White Sox have won each of their last three games as underdogs against National League opponents.
The Pirates have failed to cover the run line in each of their last nine games as home favorites against AL Central opponents following a loss.
The White Sox have covered the run line in eight of their last nine road games against NL Central opponents that held a losing record.
The White Sox have led after 5 innings in six of their last eight games at PNC Park against NL Central opponents that held a losing record.

Total Runs Facts

Six of the Pirates’ last seven day games as favorites have gone UNDER the total runs line.
Five of the White Sox’s last six games against NL Central opponents have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in 15 of the Pirates’ last 17 games as favorites.
The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games as road underdogs against National League opponents.

Pittsburgh Pirates Player Prop Facts

Andrew Heaney has recorded four or more strikeouts in each of his last nine appearances with his team as a home favorite.
Bryan Reynolds has recorded a Double in each of the Pirates’ last three games against opponents that held a losing record.
Tommy Pham has hit a home run in four of his last 16 appearances.
Andrew Heaney has recorded a win in each of his last five Sunday appearances with his team as a favorite.
Ke’Bryan Hayes has recorded at least one hit in each of his last 13 home appearances after playing the previous day.

Chicago White Sox Player Prop Facts

Aaron Civale has recorded four or more strikeouts in nine of his last 10 appearances with his team as an underdog against NL opponents.
Michael A. Taylor has recorded a Double in each of his last three appearances with the White Sox as road underdogs against NL opponents.
Luis Robert has hit a home run in two of his last three appearances against NL opponents.
Aaron Civale has recorded a win in three of his last four road appearances against NL opponents that held a losing record.
Luis Robert has recorded at least one hit in each of his last eight appearances against opponents that held a losing record.

White Sox vs Pirates Prediction 

Chicago comes into this contest looking for a very rare series sweep on the road, as they are just 13-36 on the road this year. The Pirates are 26-23 at home this season, but they have been very bad over their last 11 games. Pittsburgh is starting Heaney, who has allowed 3, 4, 0, 7, and 7 earned runs in his last five starts. Chicago is starting Civale, who has allowed at least four earned runs in three of his last five. I think we will see some offense here, so I like the over. 

David Racey's Pick: Over 8.5

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