White Sox vs Nationals Prediction 9/27/2025 Today’s MLB Picks

In this article we will formulate a White Sox vs Nationals prediction for this MLB game on Saturday, September 27th at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 59-101 this season after they won game one by a score of 10-9 on Friday night. Chicago led 8-1 in the fifth inning, but they blew the lead and needed two runs in the ninth to get the win. The White Sox recorded 11 hits in the game and they were led by Sosa, who went 3-4 with one home run and three RBIs in the win. Chicago started Gomez, who allowed eight hits and five earned runs over 6.0 innings, while Ellard got the win and Taylor picked up the save. 

Prior to this series, the White Sox lost all three against the Yankees and two out of three against the Padres. Chicago has lost five of their last six games and they are last in the AL Central standings. The Chicago pitching staff has a 4.28 ERA with a 1.37 WHIP and a .249 opponent batting average, while the offense has scored 634 runs with a .232 batting average and a .301 on base percentage this season. Lenyn Sosa has led Chicago with 22 home runs and 75 RBIs, while Andrew Benintendi has added 20 home runs and 63 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 4-11 with a 4.29 ERA and a 1.47 WHIP over 130.0 innings pitched this season. 

Washington Nationals Betting Preview

The Washington Nationals are 65-95 this year after they lost game one by a score of 10-9 on Friday night. Washington scored eight straight runs to take the lead in the late innings, but the bullpen couldn’t hold the lead in the loss. The Nationals recorded 13 hits and they committed four errors in the game, while they were led by Garcia Jr, who went 3-4 with three home runs and four RBIs in the loss. Washington started Cavalli, who allowed seven hits and two earned runs over 4.0 innings, while Ferrer picked up the loss. 

Prior to this series, the Nationals lost two out of three against the Braves, but did win two out of three against the Mets before that. Washington has lost three of their last four games and they are last in the NL East standings. The Washington pitching staff has a 5.33 ERA with a 1.45 WHIP and a .268 opponent batting average, while the offense has scored 681 runs with a .243 batting average and a .305 on base percentage this season. James Wood has led Washington with 30 home runs and 92 RBIs, while Josh Bell has added 22 home runs and 63 RBIs this year. The projected starting pitcher for Washington is Jake Irvin, who is 9-13 with a 5.69 ERA and a 1.44 WHIP over 174.0 innings pitched this year. 

Why the White Sox will beat the Nationals 

The Nationals have lost each of their last seven games against American League opponents.
The White Sox have won four of their last five games as underdogs against National League opponents following a road win.
The White Sox have covered the run line in each of their last eight games as road underdogs against National League opponents.
The Nationals have failed to cover the run line each of their last seven games against American League opponents that held a losing record.
The White Sox have won the first inning in three of their last four games against National League opponents.
The White Sox have led after 3 innings in six of their last seven games against NL East opponents that held a losing record.
The White Sox have led after 5 innings in six of their last seven day games against opponents that held a losing record.

Total Runs Facts

Each of the Nationals’ last six day games as favorites have gone UNDER the total runs line.
Five of the White Sox’s last six road games against NL East opponents have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Nationals’ last four home games against AL Central opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in 14 of the White Sox’s last 18 games as road underdogs against National League opponents.

Washington Nationals Player Prop Facts

Josh Bell has recorded at least one hit in each of his last six appearances against AL opponents.
CJ Abrams has hit a home run in each of the Nationals’ last two games against AL Central opponents.

Chicago White Sox Player Prop Facts

Michael A. Taylor has recorded a Double in three of his last four road appearances against NL opponents.
Mike Tauchman has recorded at least one hit in each of his last nine road appearances against NL opponents that held a losing record.
Luis Robert has hit a home run in two of his three previous road appearances against the Nationals.

White Sox vs Nationals Prediction 

These two teams played a very high scoring game on Friday night, so they will be looking for some length out of their starters here. The White Sox are 26-53 on the road this year, while the Nationals are 31-48 at home. Washington is starting Irvin, who has allowed 2, 5, 3, 7, and 4 earned runs over his last five outings. Chicago is going with Burke, who has allowed two earned runs or fewer in four of his last five, but hasn’t gone past 4.1 innings in any of those five. I do not like what I have seen from Irvin recently, so give me the Sox to win here.