White Sox vs Astros Prediction 9/29/2026 Today’s MLB Picks

In this article we will formulate a White Sox vs Astros prediction for this MLB game on Tuesday, September 29th at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB playoff matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 84-78 this season after they won two out of three against the Rockies by scores of 6-1, 6-9, and 4-2. In game three, Chicago scored four runs in the third inning, which was enough to get the win. The White Sox recorded eight hits in the game and they were led by Grichuk, who went 1-3 with one home run and two RBIs. Kay allowed five hits and one earned run over 5.0 innings for the win, while Richards picked up the save. Prior to that series, Chicago won two out of three against the Royals and three out of four against the Tigers. 

This season, Chicago has a 4.12 ERA with a 1.31 WHIP and a .243 opponent batting average, while they have scored 776 runs with a .236 batting average and a .320 on base percentage. Colson Montgomery has led the White Sox with 31 home runs and 87 RBIs, while Miguel Vargas has added 33 home runs and 93 RBIs. The projected starting pitcher for Chicago is Hagen Smith, who is 3-3 with a 1.29 ERA and a 0.96 WHIP over 28.0 innings pitched this season. 

Houston Astros Betting Preview

The Houston Astros are 81-81 this year after they won three out of four against the Athletics by scores of 7-5, 5-6, 13-2, and 9-0. In game four, Houston scored four runs in the third inning and never looked back in the shutout win. The Astros recorded 12 hits in the game and they were led by Spence, who went 1-2 with two RBIs. Lambert allowed two hits and zero earned runs over 2.0 innings, while Pecko got the win in relief. Prior to that series, Houston split two games with the Mariners and lost all three against the Braves. 

This season, Houston has a 4.45 ERA with a 1.34 WHIP and a .237 opponent batting average, while they have scored 734 runs with a .242 batting average and a .315 on base percentage. Yordan Alvarez has led the Astros with 42 home runs and 106 RBIs, while Christian Walker has added 29 home runs and 87 RBIs. The projected starting pitcher for Houston is AJ Blubaugh, who is 5-3 with a 3.66 ERA and a 1.23 WHIP over 96.0 innings pitched this year. 

Why the Houston Astros will win

• The White Sox have lost each of their last seven games at Daikin Park following a win.
• The favorites have won each of the White Sox’s last six games at Daikin Park.
• The White Sox have failed to cover the run line in each of their last five day playoff games against AL West opponents.
• The favorites have covered the run line in each of the White Sox’s last four games at Daikin Park.
• The White Sox have trailed after 5 innings in four of their last five day playoff games against AL West opponents.
• The Astros have led after 3 innings in three of their last four home games against AL opponents.

Why the Chicago White Sox will win

• The Astros have lost each of their last seven playoff games as home favorites.
• The White Sox have won four of their last five games as underdogs against AL West opponents following a home win.
• The Astros have failed to cover the run line in each of their last seven playoff games at Daikin Park.
• The White Sox have covered the run line in 21 of their last 24 games as underdogs against AL West opponents following a home win.
• The Astros have trailed after 5 innings in six of their last seven home playoff games.
• The Astros have trailed after 3 innings in three of their last four day games against AL opponents that held a winning record.

Total Runs Facts

• Each of the White Sox’s last six road games against AL opponents have gone OVER the total runs line.
• Each of the Astros’ last six games against AL Central opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in five of the White Sox’s last six games.
• There has been no run scored during the first inning in four of the last five games between the White Sox and Astros at Daikin Park.

Houston Astros Player Prop Facts

• Christian Walker has hit a home run in three of the Astros’ last four games as favorites.
• Isaac Paredes has recorded at least one hit in each of the Astros’ last 13 games at Daikin Park against AL opponents that held a winning record.
• Yordan Alvarez ranks 1st amongst qualified players for Slugging Percentage (.601) this season.

Chicago White Sox Player Prop Facts

• Munetaka Murakami has recorded at least one hit in each of his nine previous road appearances after not playing the previous day.
• Brenton Doyle has hit a home run in each of the White Sox’s last two games.

Matchup/League Facts

• The Astros rank 29th in the league for walks allowed this season (650).
• The Astros rank 4th in the league for slugging percentage this season (.417).
• The White Sox rank 5th in the league for home runs this season (211).
• The White Sox rank 5th in the league for RBIs this season (740).

White Sox vs Astros Prediction 

Houston comes into this matchup after winning the AL West on the last day of the regular season and they will have the home field advantage. The Astros are 39-42 at home this year, while the White Sox are 36-45 on the road. Chicago just missed out on winning the AL Central and they have really struggled on the road this year. The White Sox are starting Smith, who hasn’t pitched more than two innings in his last five outings, while Blubaugh will also be an opener. I know Houston is at home, but I think Chicago has the more balanced lineup. Take the White Sox here.

David Racey's Pick: White Sox ML