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Washington Nationals vs St. Louis Cardinals Prediction 9/20/2026 Today’s MLB Picks

Sep 18, 2026; St. Louis, Missouri, USA;  Washington Nationals catcher Harry Ford (17) is forced out at second from St. Louis Cardinals shortstop Masyn Winn (0) during the sixth inning at Busch Stadium.  Mandatory Credit: Jeff Le-Imagn Images

Sep 18, 2026; St. Louis, Missouri, USA; Washington Nationals catcher Harry Ford (17) is forced out at second from St. Louis Cardinals shortstop Masyn Winn (0) during the sixth inning at Busch Stadium. Mandatory Credit: Jeff Le-Imagn Images

MATCHUP Washington Nationals St. Louis Cardinals
Team Records 73-82 75-80
Spread +1.5 -164 -1.5 135
Moneyline +123 -149
Total Over 9 (-109) Under 9 (-111)
Where Busch Stadium, St. Louis, Missouri
When Sunday, September 20, 2026
Time 02:15 PM EDT
TV MLB.TV
The Washington Nationals and St. Louis Cardinals meet Sunday in MLB action at Busch Stadium. Here’s a Washington Nationals vs. St. Louis Cardinals Prediction. This article will include a Washington Nationals vs. St. Louis Cardinals Pick.

Washington Nationals Betting Preview 


The Washington Nationals are 73-82 on the year and play the Tigers and Mets next. The Washington Nationals are batting .247 on the season, with a .323 OBP and a .426 slugging percentage. The Washington Nationals’ pitching staff has a 4.69 ERA and a 1.39 WHIP. CJ Abrams leads the Washington Nationals with 145 hits and 97 RBI, while James Wood and Daylen Lile have combined for 271 hits and 162 RBI. 

Jake Irvin gets the ball for the Washington Nationals, and he is 2-9 with a 5.51 ERA and 96 strikeouts this season. Irvin is 1-1 with a 6.28 ERA and 11 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview 


The St. Louis Cardinals are 75-80 on the year and play the Pirates and Brewers next. The St. Louis Cardinals are batting .242 on the season, with a .316 OBP and a .381 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.30 ERA and a 1.36 WHIP. Alec Burleson leads the St. Louis Cardinals with 164 hits and 111 RBI, while Jordan Walker and Ivan Herrera have combined for 298 hits and 165 RBI.

Quinn Mathews gets the ball for the St. Louis Cardinals, and he is 2-3 with a 3.62 ERA and 36 strikeouts this season. This will be Mathews’ first career game against the Washington Nationals.

Why the St. Louis Cardinals will win

Why the Washington Nationals will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Washington Nationals Player Prop Facts

Matchup/League Facts

Washington Nationals vs St. Louis Cardinals Prediction


The Cardinals should have the edge at home with Mathews on the mound. He’s been a solid rookie through 37.1 innings with a 3.62 ERA and 1.39 WHIP. However, as I’ve said all series, if forced to get involved with either side at this stage of the season, I need a favorable price attached. Give me some bang for my buck. Give me some plus money. The Nationals have also been more competitive overall and are playing through the finish line. The Nats haven’t rolled over and died. I’ll take the underdog yet again, even if Irvin isn’t an attractive option on the mound.

Randy Chambers's Pick: Washington Nationals

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