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Washington Nationals vs Cleveland Guardians Prediction 5/25/2026 Today’s MLB Picks

May 4, 2026; Kansas City, Missouri, USA; Cleveland Guardians starting pitcher Tanner Bibee (28) delivers a pitch against the Kansas City Royals during the first inning at Kauffman Stadium. Mandatory Credit: Denny Medley-Imagn Images

May 4, 2026; Kansas City, Missouri, USA; Cleveland Guardians starting pitcher Tanner Bibee (28) delivers a pitch against the Kansas City Royals during the first inning at Kauffman Stadium. Mandatory Credit: Denny Medley-Imagn Images

MATCHUP Washington Nationals Cleveland Guardians
Team Records 27-27 32-23
Spread +1.5 -144 -1.5 119
Moneyline +148 -180
Total Over 8 (-114) Under 8 (-106)
Where Progressive Field, Cleveland, Ohio
When Monday, May 25, 2026
Time 06:10 PM EDT
TV MLB.TV
In this article, we will formulate a Nationals vs Guardians Prediction for this MLB matchup on Monday, May 25th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Preview


The Cleveland Guardians have a 32-23 record this season and are sitting in the first place of the AL Central. They have a 15-10 home record and are coming off a 3-1 road win against the Phillies. They will face the Red Sox and the Yankees next.

The Guardians have a .228 batting average this season, .320 OBP and .373 Slugging percentage. Cleveland’s pitching staff has a 3.55 ERA and 1.25 WHIP. Brayan Rocchio is the team’s best hitter with a .286 batting average. Chase DeLauter leads the team in RBI with 30, while Angel Martinez adds a team-high 9 home runs.

Tanner Bibee (R) is the projected starting pitcher for the Guardians, and he has a 0-6 record, 3.75 ERA and 1.25 WHIP.

Washington Nationals Preview


The Washington Nationals have a 27-27 record this season and are sitting in the second place of the NL East. They have a 17-11 away record and are coming off a 2-1 road win against the Braves. They will face the Padres and the Marlins next.

The Nationals have a .243 batting average this season, .322 OBP and .413 Slugging percentage. Washington’s pitching staff has a 4.80 ERA and 1.38 WHIP. CJ Abrams is the team’s best hitter with a .289 batting average, also leading the team in RBI with 45. James Wood adds a team-high 13 home runs.

Zack Littell (R) is the projected starting pitcher for the Nationals, and he has a 3-4 record, 5.83 ERA and 1.45 WHIP.

Washington Nationals @ Cleveland Guardians Betting Trends: May 25, 2026


Why the Cleveland Guardians will win


Why the Washington Nationals will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Washington Nationals Player Prop Facts

Matchup/League Facts

Nationals vs Guardians Prediction


The Guardians are 4-2 in their last 6 meetings against the Nationals but are 1-2 in their last three visits in Washington.

In this Nationals vs Guardians Prediction, the Guardians are coming as -180 home favorites. The Guardians have been red-hot lately with an 8-1 record in their last 9 games and are facing a Nationals team that won a series against the Braves with back-to-back wins and are major candidates for a letdown in this spot. The Guardians have both the pitching edge as Bibee goes up against a struggling Zack Littell, and a superior bullpen, so pick them to take care of business at home.

Nikos Lagouretos's Pick: Cleveland Guardians ML

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