Cincinnati (52-48) vs Washington (39-60)
July 21, 2025 at 06:45 PM EDT
The Line: Betting Odds: Washington +115 — Over/Under: +9
The Cincinnati Reds and the Washington Nationals meet Monday in MLB action from Nationals Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cincinnati Reds vs. Washington Nationals prediction.
Starting Pitching Matchup
The Cincinnati Reds will send out Brady Singer for the start here, and Singer is 7-7 with a 4.32 ERA and 92 strikeouts this season. This will be Singer’s second career start against the Nationals. The Washington Nationals will start Jake Irvin here, and Irvin is 7-5 with a 4.58 ERA and 83 strikeouts this season. In his career, Irvin is 0-1 with a 4.43 ERA and 20 strikeouts against Cincinnati.
Cincinnati Reds Recap
The Cincinnati Reds come into this game looking to rebound from a 3-2 loss at the hands of the New York Mets in Sunday’s series finale to sit at 52-48 on the year. After this series, the Reds will head home for a series against the Tampa Bay Rays.
Reds Have Four-Game Win Streak Snapped
Elly De La Cruz has 107 hits with 18 home runs, 65 RBIs, 18 doubles, and 25 stolen bases, while TJ Friedl has 97 hits with 15 doubles, 9 home runs, and 33 RBIs with 10 stolen bases. Gavin Lux has added 73 hits with 17 doubles and 37 RBIs while Spencer Steer has 11 home runs and 40 RBIs, and Matt McLain has added 11 homers, 35 RBIs, and 14 stolen bases as well on the year. Jose Trevino’s also chipped in 17 doubles this season.
Why the Cincinnati Reds will win
The Nationals have lost eight of their last nine home games against NL Central opponents.
The Reds have won four of their last five games.
The Nationals have failed to cover the run line in 10 of their last 11 home games against National League opponents.
The Reds have covered the run line in each of their last five games against NL East opponents.
Cincinnati Reds Player Prop Facts
Elly De La Cruz has hit a home run in six of the Reds’ last 19 road games.
Brady Singer has recorded five or more strikeouts in seven of his last nine road appearances against NL opponents.
Elly De La Cruz has recorded at least one Double in four of the Reds’ last five games at Nationals Park against opponents that held a losing record.
Brady Singer has recorded a win in three of his last four appearances with his team as a road favorite .
Connor Joe has recorded at least one hit in each of his last 10 road appearances against NL East opponents that held a losing record.
Elly De La Cruz ranks T7th in the league in Steals (25) this season.
Washington Nationals Recap
The Washington Nationals come into this game looking to rebound from an 8-1 loss at the hands of the Padres in Sunday’s series finale to sit at 39-60 on the year. After this series, the Nationals will head on the road for a series against the Minnesota Twins.
Nationals Drop 8 Of Their Last 10 Games
Keibert Ruiz has 63 hits with 12 doubles and a pair of home runs with 25 RBIs while James Wood has 100 hits with 19 doubles and a team-high 24 home runs along with 69 RBIs and 13 stolen bases while also putting up 121 strikeouts. Nathaniel Lowe has 86 hits with 14 doubles and 62 RBIs along with 15 home runs and 113 strikeouts. CJ Abrams has 13 home runs and 36 RBIs along with 21 doubles and 20 stolen bases while Luis Garcia Jr. has 20 doubles and 8 stolen bases of his own this season. Dylan Crews has also logged 11 stolen bases as well this season.
Why the Washington Nationals will win
The Nationals have won each of their last three games as underdogs against the Reds following a loss.
The Reds have lost four of their last five games as favorites following a road loss.
The Nationals have covered the run line in seven of their last eight games against the Reds.
The Reds have failed to cover the run line in eight of their last nine games against the Nationals following a loss.
Washington Nationals Player Prop Facts
CJ Abrams has recorded at least one hit in each of the Nationals’ last 14 night games.
Josh Bell has recorded a Double in four of the Nationals’ last five night games against NL Central opponents that held a winning record.
Amed Rosario has hit a home run in three of his last five appearances in night games against NL Central teams that held a winning record.
James Wood ranks T10th in the league in Home Runs (24) this season.
Total Runs Facts
Each of the Reds’ last six games after playing the previous day have gone UNDER the total runs line.
Eight of the Nationals’ last nine home games have gone OVER the total runs line.
Cincinnati Reds vs. Washington Nationals Prediction
I’m on the Reds here. Brady Singer has been a solid pitcher on the road for much of the season and the Reds behind him have been a really solid lineup against right-handed pitching this season. Jake Irvin for me is just not a reliable option for the Nationals, and I think the Reds get to him early and often on their way to a series-opening win on the road here. Give me Cincinnati in this one.