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Twins vs Phillies Prediction 9/27/2025 Today’s MLB Picks

Sep 25, 2025; Arlington, Texas, USA; Minnesota Twins center fielder Byron Buxton (25) celebrates as he rounds the bases after hitting a three run home run against the Texas Rangers during the eighth inning at Globe Life Field. Mandatory Credit: Jerome Miron-Imagn Images

Sep 25, 2025; Arlington, Texas, USA; Minnesota Twins center fielder Byron Buxton (25) celebrates as he rounds the bases after hitting a three run home run against the Texas Rangers during the eighth inning at Globe Life Field. Mandatory Credit: Jerome Miron-Imagn Images

Minnesota (69-91) vs Philadelphia (95-65)

September 27, 2025 at 06:05 PM EDT

The Line: Betting Odds: Philadelphia -190 — Over/Under: +8.5

(Get latest betting odds)

In this article we will formulate a Twins vs Phillies prediction for this MLB game on Saturday, September 27th at Citizens Bank Park in Philadelphia, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 69-91 this year after they lost game one by a score of 3-1 on Friday night. Minnesota cut the deficit to 2-1 in the sixth inning, but couldn’t get any closer in the loss. The Twins recorded four hits in the game and they were led by Vazquez, who went 2-3 with one home run and one RBI in the loss. Minnesota started Ryan, who allowed five hits and two earned runs over 5.0 innings for the loss, while Adams allowed one earned run in relief. 

Prior to this series, the Twins won two out of three against the Rangers, but lost three out of four against the Guardians before that. Minnesota has won three of their last five games and they are fourth in the AL Central standings. The Minnesota pitching staff has a 4.61 ERA with a 1.32 WHIP and a .258 opponent batting average, while their offense has scored 672 runs with a .238 batting average and a .311 on base percentage this season. Byron Buxton has led Minnesota with 34 home runs and 82 RBIs, while Matt Wallner has added 22 home runs and 40 RBIs this year. The projected starting pitcher for Minnesota is Mick Abel, who is 2-4 with a 7.36 ERA and a 1.67 WHIP over 33.0 innings pitched this year. 

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 95-65 this season after they won game one by a score of 3-1 last night. Philadelphia scored in the first inning and they led the whole way in the low scoring victory. The Phillies recorded eight hits in the game and they were led by Sosa, Marsh, and Bohm, who all had one RBI in the win. Philadelphia started Nola, who allowed two hits and one earned run over 8.0 innings for the win, while Duran got the save. 

Prior to this series, the Phillies won two out of three against the Marlins, but lost two out of three against the Diamondbacks before that. Philadelphia has won three games in a row and they are first in the NL East standings. The Philadelphia pitching staff has a 3.81 ERA with a 1.23 WHIP and a .245 opponent batting average, while the offense has scored 776 runs with a .260 batting average and a .329 on base percentage this season. Kyle Schwarber has led Philadelphia with 56 home runs and 132 RBIs, while Nick Castellanos has added 17 home runs and 71 RBIs this year. The projected starting pitcher for Philadelphia is Ranger Suarez, who is 12-7 with a 3.12 ERA and a 1.20 WHIP over 153.0 innings pitched this season. 

Why the Phillies will beat the Twins 

The Phillies have won each of their last eight night games against American League opponents following a win.
The Twins have lost each of their last nine Saturday night games.
The Phillies have covered the run line in each of their last eight night games against American League opponents following a win.
The Twins have failed to cover the run line in each of their last nine Saturday night games.
The Phillies have won the first inning in four of their last five games at Citizens Bank Park.
The Twins have trailed after 3 innings in five of their last six night games against NL East opponents that held a winning record.
The Twins have trailed after 5 innings in four of their last five road games against NL East opponents.

Total Runs Facts

Each of the Twins’ last six games as underdogs have gone UNDER the total runs line.
Six of the Phillies’ last seven home games against American League opponents have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Phillies’ last six games against American League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Twins’ last nine games as underdogs.

Philadelphia Phillies Player Prop Facts

Kyle Schwarber has hit at least one home run in four of the Phillies’ last six games at Citizens Bank Park.
Trea Turner has recorded at least one hit in each of his 11 previous appearances with his team as a favorite against the Twins.
Ranger Suarez has recorded five or more strikeouts in 12 of his last 14 appearances in night games.
Ranger Suarez has recorded a win in three of his last four appearances at Citizens Bank Park.
Trea Turner has recorded a Double in four of his last five appearances at Citizens Bank Park against AL Central opponents that held a losing record.

Minnesota Twins Player Prop Facts

Byron Buxton has hit at least one home run in four of his last six appearances with the Twins as road underdogs.
Christian Vazquez has recorded two or more hits in each of his last three road appearances against NL opponents.

Twins vs Phillies Prediction 

Philadelphia was able to get the win to start this series on Friday and they have allowed just two total runs in their last three game. The Phillies are 54-25 at home this season, while the Twins are 31-48 on the road. Minnesota is starting Abel, who has allowed 13 earned runs in his last 8.0 innings of work. Philadelphia is going with Suarez, who has allowed nine earned runs in his last 10.0 innings. Both of these pitchers have had recent issues, but Suarez is the much better option and the Phillies are miles ahead offensively. Take Philadelphia to win by at least two runs here.

David Racey's Pick: Phillies -1.5

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