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Twins vs Guardians Prediction 7/20/2026 Today’s MLB Picks

Jun 6, 2026; Minneapolis, Minnesota, USA; Minnesota Twins pitcher Joe Ryan (41) throws a pitch against the Kansas City Royals during the first inning at Target Field. Mandatory Credit: Jeffrey Becker-Imagn Images

Jun 6, 2026; Minneapolis, Minnesota, USA; Minnesota Twins pitcher Joe Ryan (41) throws a pitch against the Kansas City Royals during the first inning at Target Field. Mandatory Credit: Jeffrey Becker-Imagn Images

MATCHUP Minnesota Twins Cleveland Guardians
Team Records 49-51 52-48
Where Progressive Field, Cleveland, Ohio
When Monday, July 20, 2026
Time 06:40 PM EDT
TV MLB.TV

In this article we will formulate a Twins vs Guardians prediction for this MLB game on Monday, July 20th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 49-51 this year after they lost two out of three against the Cubs by scores of 5-2, 2-6, and 1-10. In game three, Minnesota allowed the first 10 runs in the game, but they scored in the eighth to avoid the shutout. The Twins recorded eight hits and they committed one error in the game, while they were led by Lewis, who went 1-3 with one RBI. Matthews allowed nine hits and eight earned runs over 3.0 innings for the loss, while Adams threw three innings in relief. Prior to that series, Minnesota won two out of three against the Angels and two out of three against the Guardians

This season, Minnesota has a 4.66 ERA with a 1.38 WHIP and a .252 opponent batting average, while they have scored 479 runs with a .248 batting average and a .322 on base percentage. Byron Buxton has led the Twins with 25 home runs and 45 RBIs, while Josh Bell has added 13 home runs and 60 RBIs. The projected starting pitcher for Minnesota is Joe Ryan, who is 6-5 with a 2.85 ERA and a 1.05 WHIP over 110.1 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 52-48 this season after they lost two out of three against the Pirates by scores of 1-7, 5-3, and 1-7. In game three, Cleveland tied the game at one in the third inning, but they failed to score over the last six innings for the loss. The Guardians recorded seven hits and they committed one error in the game, while they were led by Kwan, who went 2-4 with one RBI. Cantillo allowed seven hits and four earned runs over 5.0 innings for the loss, while Dion allowed two earned runs in relief. Prior to this series, Cleveland swept the Marlins in three games, but lost two out of three against the Twins before that. 

This season, Cleveland has a 3.76 ERA with a 1.27 WHIP and a .238 opponent batting average, while they have scored 392 runs with a .230 batting average and a .310 on base percentage. Chase DeLauter has led the Guardians with 11 home runs and 47 RBIs, while Angel Martinez has added 11 home runs and 33 RBIs. The projected starting pitcher for Cleveland is Tanner Bibee, who is 3-9 with a 3.90 ERA and a 1.15 WHIP over 113.0 innings pitched this season. 

Why the Cleveland Guardians will win

Why the Minnesota Twins will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Minnesota Twins Player Prop Facts

Matchup/League Facts

Twins vs Guardians Prediction 

Minnesota comes into this matchup after allowing 16 runs in their last two games and they are now four games back in the AL Central. The Twins are 23-26 on the road this year, while the Guardians are 25-24 at home. Cleveland is also coming off of a series loss and they were outscored 17-7 in that three game series. The Guardians are starting Bibee, who has allowed two earned runs or fewer in three of his last four starts, while Ryan has allowed two earned runs in his last 17.0 innings of work. I think this game could go either way, but I don’t expect much offense. Take the under here.

David Racey's Pick: Under 7.5

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