| MATCHUP | Toronto Blue Jays | Baltimore Orioles |
|---|---|---|
| Team Records | 77-80 | 76-81 |
| Spread | +1.5 -207 | -1.5 169 |
| Moneyline | +101 | -122 |
| Total | Over 7.5 (-114) | Under 7.5 (-106) |
| Where | Oriole Park at Camden Yards, Baltimore, Maryland | |
| When | Tuesday, September 22, 2026 | |
| Time | 06:35 PM EDT | |
| TV | MLB.TV | |
In this article, we will formulate a Blue Jays vs Orioles Prediction for this MLB matchup on Tuesday, September 22nd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.
Baltimore Orioles Preview
The Baltimore Orioles have a 76-81 record this season and are sitting in the 5th place of the AL East. They have a 37-42 home record and are coming off a 4-3 home win against the Blue Jays. They will face the Yankees next.
The Baltimore Orioles have a .234 batting average this season, .314 OBP and .395 Slugging percentage. Baltimore’s pitching staff has a 4.11 ERA and 1.34 WHIP. Pete Alonso is the team’s best hitter with a .265 batting average, leading the team in RBI with 108 and adding a team-high 40 home runs.
Chris Bassitt (R) is the projected starting pitcher for the Orioles, and he has a 8-5 record, 4.64 ERA and 1.55 WHIP.
Toronto Blue Jays Preview
The Toronto Blue Jays have a 77-80 record this season and are sitting in the 4th place of the AL East. They have a 37-42 away record and are coming off a 3-4 road loss against the Orioles. They will face the Reds next.
The Toronto Blue Jays have a .248 batting average this season, .310 OBP and .382 Slugging percentage. Toronto’s pitching staff has a 3.92 ERA and 1.30 WHIP. Ernie Clement is the team’s best hitter with a .264 batting average. Kazuma Okamoto leads the team in RBI with 89, adding a team-high 33 home runs.
Max Scherzer (R) is the projected starting pitcher for the Blue Jays, and he has a 3-8 record, 6.07 ERA and 1.36 WHIP.
Toronto Blue Jays @ Baltimore Orioles Betting Trends: September 22, 2026
- Probable Starting Pitcher: Chris Bassitt Record this season: 8-5 ERA: 4.64
- Home Record: 3-2
- Last 5 against Blue Jays: 1-1
Why the Baltimore Orioles will win
- The Blue Jays have lost each of their last six night games against AL opponents.
- The Orioles have won 10 of their last 11 night games against teams that held a losing record.
- The Blue Jays have failed to cover the run line in each of their last six night games against AL opponents.
- The Orioles have covered the run line in seven of their last eight home games against AL opponents that held a losing record.
- The Orioles have led after 5 innings in four of their last five games as favorites against AL opponents.
- The Orioles have led after 3 innings in four of their last five night games against AL opponents that held a losing record.
- Probable Starting Pitcher: Max Scherzer Record this season: 3-8 ERA: 6.07
- Road Record: 0-1
- Last 5 against Orioles: 0-3
Why the Toronto Blue Jays will win
- The Blue Jays have won 10 of their last 11 games as underdogs following a loss.
- The Orioles have lost five of their last six games as favorites against AL East opponents following a home win.
- The Blue Jays have covered the run line in 10 of their last 11 games as underdogs following a loss.
- The Orioles have failed to cover the run line in five of their last six games as favorites.
- The Blue Jays have led after 5 innings in each of their last four road games against AL East opponents that held a losing record.
- The Blue Jays have led after 3 innings in each of their last four road games against AL East opponents that held a losing record.
- The Orioles have lost the first inning in each of their last three home games against AL opponents.
Total Runs Facts
- Nine of the last 10 games between the Blue Jays and Orioles have gone OVER the total runs line.
- Seven of the Blue Jays’ last eight games as underdogs against the Orioles have gone OVER the total runs line.
- There has been at least one run scored in the first inning in each of Max Scherzer’s last eight appearances as a starter.
- There has been at least one run scored in the first inning in each of the Orioles’ last four night games against AL opponents.
Baltimore Orioles Player Prop Facts
- Pete Alonso has hit at least one home run in four of the Orioles’ last five night games.
- Chris Bassitt has recorded four or more strikeouts in 28 of his last 29 home appearances against AL opponents that held a losing record.
- Pete Alonso has recorded at least one hit in each of his last six home appearances against the Blue Jays.
- Chris Bassitt has recorded a win in four of his last five appearances.
- Pete Alonso ranks T4th in the league in Home Runs (40) this season.
Toronto Blue Jays Player Prop Facts
- Kazuma Okamoto has hit a home run in four of the Blue Jays’ last seven night games against opponents that held a losing record.
- Max Scherzer has recorded six or more strikeouts in six of his last seven road appearances against the Orioles.
- Alejandro Kirk has recorded at least one hit in each of his last 14 appearances with the Blue Jays as underdogs.
- Kazuma Okamoto ranks T10th in the league in Home Runs (33) this season.
Matchup/League Facts
- The Orioles rank 28th in the league for strikeouts against this season (1474).
- The Orioles rank 27th in the league for batting average this season (.234).
- The Blue Jays rank 30th in the league for triples this season (8).
- The Blue Jays rank 29th in the league for runs scored this season (632).
Blue Jays vs Orioles Prediction
The Blue Jays are 4-2 in their last 6 meetings against the Orioles but have lost their last three visits in Baltimore.
In this Blue Jays vs Orioles Prediction, the Orioles are coming as -120 home favorites. I like the Orioles to keep rolling at home as long as they have a mathematical chance for the wild card spot. Bassitt has been solid at home with a 3.53 ERA, while Scherzer has been shaky at best. The Orioles’ bullpen has been in excellent form lately and have been much better against right-handed pitching than the Jays in their last 5 games. Take the Orioles to win this one at home.