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Tampa Bay Rays vs San Diego Padres Prediction 4/27/25 MLB Picks

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San Diego Padres (17-10) vs Tampa Bay Rays (13-14)

Game Info: Sunday, April 27, 2025 at 4:10 pm (Petco Park)

The Line: Betting Odds: San Diego Padres -118 / Tampa Bay Rays -102 — Over/Under: 8

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The Tampa Bay Rays and the San Diego Padres meet Sunday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tampa Bay Rays vs. San Diego Padres prediction.

Starting Pitching Matchup

The Tampa Bay Rays will send out Zack Littell for the start here, and Littell is 0-5 with a 5.28 ERA and 21 strikeouts this season. This will be Littell’s first career start against the Padres. Randy Vasquez will get the start for the Padres here, and Vasquez is 1-2 with a 3.97 ERA and 9 strikeouts this season. This will be Vasquez’s second career start against the Rays.

Tampa Bay Rays Recap

The Tampa Bay Rays come into this game looking to add on to their 4-1 win over the Padres in Saturday’s matchup to improve to 13-14 on the year. After this series, the Rays will head home for a series against the Kansas City Royals.

Rays Win 4th In A Row

Jake Mangum has 23 hits, including 4 doubles and 7 RBIs, with a team-high 8 stolen bases, while Jonathan Aranda has 25 hits with a team-high 8 doubles, 4 home runs, and 13 RBIs. Brandon Lowe has 20 hits with 4 homers and 14 RBIs as well, while Junior Caminero has 25 hits with 5 doubles, a team-high 5 home runs, and 12 RBIs. Yandy Diaz has 28 hits with 7 doubles, 3 homers, and 13 RBIs, and Kameron Misner has 23 hits with 7 doubles, 3 homers, and 11 RBIs as well, while Christopher Morel has a team-high 35 strikeouts this season. Jose Caballero has 7 stolen bases, while Taylor Walls and Jonny DeLuca each have 4 stolen bases as well this season.

Why the Tampa Bay Rays will win

Tampa Bay Rays Player Prop Facts

San Diego Padres Recap

The San Diego Padres come into this game looking to snap out of their funk after another sluggish showing in Saturday’s loss, falling to 17-10 on the year. After this series, the Padres will welcome the rival San Francisco Giants to town for a series.

Padres Drop Three In A Row, Score 1 Run Combined

Manny Machado has 28 hits, including a team-high 10 doubles and 6 stolen bases, while Fernando Tatis Jr. has 35 hits with a team-high 8 home runs and 18 RBIs, along with 7 stolen bases of his own this season. Luis Arraez has added 25 hits with 3 doubles, while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 8 doubles and 4 stolen bases this season. Gavin Sheets also has 4 doubles, 3 home runs, and 12 RBIs as well this season.

Why the San Diego Padres will win

San Diego Padres Player Prop Facts

Total Runs Facts

Tampa Bay Rays vs. San Diego Padres Prediction

I’m on the over here. I get any sort of hesitation, as we’ve seen low-scoring games in this series. However, Zack Littell, despite back-to-back quality starts, still isn’t a starter I trust right now, as this Padres lineup is still far too talented to continue struggling like this. On the other side, Randy Vasquez is starting to show signs of regression, and the Rays got to him for 9 runs in his lone start against them last season. I think we’ll see some offensive fireworks to close out the series. Give me the over here.

Chris Ruffolo's Pick: Over 8

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