Tampa Bay Rays vs New York Yankees Prediction 9/22/2026 Today’s MLB Picks

Randy Chambers

19 minutes ago

Sep 16, 2026; Minneapolis, Minnesota, USA; New York Yankees starting pitcher Carlos Rodon (55) exits the field after the final out against the Minnesota Twins in the third inning at Target Field. Mandatory Credit: Matt Blewett-Imagn Images

MATCHUP	Tampa Bay Rays	New York Yankees
Team Records	95-60	89-66
Spread	+1.5 -206	-1.5 168
Moneyline	+109	-131
Total	Over 7 (-109)	Under 7 (-110)
Where	Yankee Stadium, Bronx, New York
When	Tuesday, September 22, 2026
Time	01:05 PM EDT
TV	ESPN Unlmtd

The Tampa Bay Rays and New York Yankees meet Tuesday in an MLB doubleheader at Yankee Stadium. Here’s a Tampa Bay Rays vs. New York Yankees Prediction. This article will include a Tampa Bay Rays vs. New York Yankees Pick.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 95-60 on the year and play the Phillies next. The Tampa Bay Rays are batting .259 on the season, have a .328 OBP, and have a .404 slugging percentage. The Tampa Bay Rays’ pitching staff has a 3.70 ERA and a 1.13 WHIP. Yandy Diaz leads the Tampa Bay Rays with 173 hits and 81 RBI, while Chandler Simpson and Junior Caminero have combined for 336 hits and 135 RBI.

Nick Martinez and Drew Rasmussen get the ball for the Tampa Bay Rays.

New York Yankees Betting Preview

The New York Yankees are 89-66 this year and play the Orioles next. The New York Yankees are batting .235 on the season, with a .311 OBP and a .410 slugging percentage. The New York Yankees’ pitching staff has a 3.22 ERA and a 1.17 WHIP. Ben Rice leads the New York Yankees with 144 hits and 95 RBI, while Cody Bellinger and Jazz Chisholm Jr. have combined for 237 hits and 126 RBI.

Carlos Rodon and Max Fried get the ball for the New York Yankees.

Why the New York Yankees will win

The Yankees have won each of their last 11 games at Yankee Stadium following a loss.
The Rays have lost 11 of their last 13 road games against AL opponents that held a winning record.
The Yankees have covered the run line in seven of their last eight games at Yankee Stadium.
The Rays have failed to cover the run line in 12 of their last 14 day games against teams that held a winning record.
The Rays have trailed after 5 innings in six of their last seven road games against AL East opponents that held a winning record.
The Rays have trailed after 3 innings in three of their last four-day games against AL East opponents that held a winning record.

Why the Tampa Bay Rays will win

The Rays have won each of their last seven games as underdogs against AL opponents following a home win.
The Yankees have lost each of their last three games on the first leg of a doubleheader.
The Rays have covered the run line in each of their last seven games as road underdogs following a home win.
The Yankees have failed to cover the run line in each of their last three home games on the first leg of a doubleheader.
The Yankees have trailed after 5 innings in six of their last eight day games at Yankee Stadium against AL opponents.

Total Runs Facts

Each of the Yankees’ last seven games as favorites against AL opponents have gone OVER the total runs line.
Each of the Rays’ last four-day games against AL East opponents have gone UNDER the total runs line.
There has been at least one run scored in the first inning in each of the Yankees’ last four home games.
There has been no run scored during the first inning in eight of the Rays’ last 10 day games against AL opponents.

New York Yankees Player Prop Facts

Austin Wells has hit a home run in three of his last four appearances with the Yankees as favorites.
Carlos Rodon has recorded five or more strikeouts in 12 of his last 13 appearances in day games against AL teams that held a winning record.
Heliot Ramos has recorded at least one hit in each of his last nine appearances in day games against AL teams that held a winning record.
Carlos Rodon has recorded a win in each of his last three appearances with the Yankees as favorites against the Rays.
Ben Rice ranks 6th amongst qualified players for Slugging Percentage (.528) this season.

Tampa Bay Rays Player Prop Facts

Jonathan Aranda has recorded at least one hit in each of his last 11 road appearances against AL opponents that held a winning record.
Nick Martinez has recorded four or more strikeouts in four of his last five appearances against AL opponents.
Nick Martinez has recorded a win in five of his last six road appearances.
Richie Palacios has hit a home run in three of his last four appearances with the Rays as underdogs.
Yandy Diaz ranks T3rd in the league in Hits (173) this season.

Matchup/League Facts

The Yankees rank 2nd in the league for home runs this season (216).
The Yankees rank 2nd in the league for opponent batting average this season (.223).
The Rays rank 1st in the league for walks allowed this season (385).
The Rays rank T2nd in the league for steals this season (159).

Tampa Bay Rays vs New York Yankees Prediction

Game 1 Prediction: Early start, two teams fighting for playoff positioning and two solid pitchers. Martinez has a 2.94 ERA and 1.07 WHIP on the season, and he’s allowed just 12 hits and 5 runs in his last 17.2 innings. Rodon has a 2.95 ERA and 1.13 WHIP on the season, and he’s allowed 9 hits and 4 earned runs in his last 17.1 innings. I expect a playoff atmosphere and low scoring. I’m rolling with the under in this spot.

Game 2 Prediction: Rasmussen has been one of the best pitchers in baseball with a 2.72 ERA and 0.93 WHIP, and he’s allowed 15 hits and 2 runs in his last 19 innings. The Rays haven’t lost on the mound with Rasmussen since July 9. Fried has been great in his own right through 106 innings, but there’s no betting against Rasmussen with how he’s pitched all year and the success the Rays have had with him on the mound. Give me the Rays in game 2.